Formulation and Antioxidant Activity Test Of Body Lotion Preparation of Ethanol Extract of Sky Mustard Leaves (Cyanthillium cinereum (L) H.Rob) As A Moisturizer

Ika Julianti Tambunan; Siti Muliani

doi:10.35451/jfm.v7i2.2441

Authors

Ika Julianti Tambunan Universitas Tjut Nyak Dhien, Medan
Siti Muliani Universitas Tjut Nyak Dhien

DOI:

https://doi.org/10.35451/jfm.v7i2.2441

Keywords:

Sky Mustard, Ethanol Extract, Body Lotion, Antioxidant, Moisturize

Abstract

The skin is the first protection to ward off free radicals. Cosmetics used on the skin throughout the body are body lotions. The content of the sky mustard leaves (Cyanthillium cinereum (L) H. Rob) are alkaloid compounds, phenols, saponins, steroids, tannins, and flavonoids that function as antioxidants. This study aims to determine the antioxidant activity of the formulation of body lotion preparations of ethanol extract of sky mustard leaves. This study was conducted using an experimental method. The method of maceration of sky mustard leaves (Cyanthillium cinereum (L) H. Rob) using 96% ethanol. The methods used include selecting a standard formula, making body lotion preparations in concentrations of 1%, 1.5%, 2% and blanks, as well as evaluating the physical quality of the preparations and testing antioxidant activity using the DPPH method.

The results showed that the leaves of the sky mustard (Cyanthillium cinereum (L) H. Rob) can be formulated into a body lotion preparation. The preparation obtained was stable and homogeneous, an oil-in-water emulsion type, pH immediately after being made 5.6 - 6.0 and after the cycling test 6.0 - 6.05, with a viscosity value of 2,300-4750 mPa's. The body lotion preparation of the sky mustard leaves with a concentration of 2% was the best preparation with a recovery percentage of 57.53% and an IC50 value of 61.38 ppm, including the "strong" category. The extract of the sky mustard leaves had an IC50 value of 14.75 ppm, which was categorized as "very strong". The blank preparation had an IC50 value of 156.91 ppm, including the "moderate" category.

Downloads

Download data is not yet available.

References

Aryantini, L. Agustina, I. Kristianingsih, E. Kurniawati, and I. Khawarizmy. “Formulasi dan Karakteristik Fisik Soothing Gel Kombinasi Lidah Buaya dan Buah Naga,” Cendekia J. Pharm., 2020: vol. 4, no. 1, pp. 1–9.

Salsabila, S. Indratmoko, and A. T. N. L. O. “Pengembangan Hand & Body Lotion Nanopartikel Kitosan dan Spirulina Sp sebagai Antioksidan,” J. Ilm. JOPHUS J. Pharm. UMUS, 2021: vol. 2, no. 01, pp. 11–20.

Slamet. “Optimasi Formulasi Sediaan Handbody Lotion Ekstrak Daun Teh Hijau,” J. Pena, 2019: vol. 33, no. 1, pp. 53–57.

Andarina and T. Djauhari. “Antioksidan Dalam Dermatologi,” J. Kedokt. dan Kesehat., 2017: vol. 4, no. 1, pp. 39–48.

Briliani, R. . Analisis Kecenderungan Pemilihan Kosmetik Wanita. J. Gaussian 5, 2016: 545– 551

Auliah, R., L. dan Anisa D., A. “Stabilitas Sediaan Lotion Ekstrak Herba Sawi Langit (Vernonia cinereal (L.) Less) Dengan Menggunakan Stearil Alkohol sebagai Emulgator. Jurnal Multidisiplin Imu, 2(2), 2023: 1-5

Samiun, A., De Queljoe, E. & Antasionasti, I. Uji Efektivitas Senyawa Flavonoid dari Ekstrak Etanol Daun Sawilangit (Veronia cinerea (L.) Less) sebagai Antipiretik pada Tikus Putih Jantan Galur Wistar (Rattus norvegicus) Yang Diinduksi Vaksin DPT. Pharmacon, 2020: 9(4). Halaman : 572–580.

Hartati, S., Angelina, M., Meilawati, L., Dewijanti, I. D. Isolation and Characterization of Compounds from the Leaves of Pterocarpus indicus Willd and Their Antioxidant Activity. Annales Bogorienses-Journal of Tropical General Botany. 20, 13–18 (2016).

Pusmarani, J., Wulandari, F., Siharis, F. S., Awaliyah, N. H., & Putri, R. J. Formulation and Antioxidant Activity of Lip Balm Containing Banana Peel (Musa paradisiaca var. Sapientum) Methanol Extract. Indonesian Journal of Pharmaceutical Science and Technology, 2023;11(1), 35–41.

Sambodo and L. E. Yani. (2020) “Formulasi Dan Efektivitas Sampo Ekstrak Buah Pedada (Sonneratia caseolaris L) Sebagai Antiketombe Terhadap Candida albicans,” J. Ris. Kefarmasian Indones., vol. 2, no. 1, pp. 1–9.

Pujiastuti, M. Kristiani, and P. K. Mangunwijaya, “Formulasi dan Uji Stabilitas Mekanik Hand and Body Lotion Sari Buah Tomat (Licopersicon esculentum Mill.) sebagai Antioksidan Formulation and Mechanical Stability Test for Hand and Body Lotionfrom Tomato Juice (Licopersiconesculentum Mill .) as Antioxi,”. 2019: vol.16, no. 1, pp. 42–55.

Kaplan, A.B. H., Cetin, M., Orgul, D., Hacimufnewlu, A., dan Hekimoglu, S. Formulation and In Vitro Evaluation of Topical Nanoemulsion based Gels Containing Daidzein. Journal of Drug Delivery Science and Technology 2019: (19): 30263.

Sulastri, L., Yayan, R., Sulistiorini, I., Renny, A dan Nina, K. Formulasi dan Uji Aktivitas Antioksidan Lotion Sari Wortel (Daucus carota L.) dengan Metode DPPH. Journal of pharmacopolium. 2021: 4(3): 11

Samiun, A., Queljoe, E D.,dan Asti, IA. The Effectiveness Test Of Flavonoid Compounds From Ethanol Extract Of Sawilangit (Vernonia Cinerea (L.) Less) As Antipyretics In Wistar Male White Rats (Rattus Norvegicus) Induced By Dpt Vaccine. Fharmacon; 9, 2020:572-580.

Muchlisyam dan Pardede, T. R. Spektrofotometri dan Analisis Multikomponen Obat. Medan: USU. 2017. Hal. 7-36.

Islamadina, R., Can, A., & Rohman, A. Chemometrics application for grouping and determinating volatile compound which related to antioxidant activity of turmeric essential oil (curcuma longa l). Journal of Food and Pharmaceutical Sciences, 2020: 1. https://doi.org/10.22146/jfps.658

Siti, M., J. Formulasi dan Uji Aktivitas Anti-Aging dan Tabir Surya Dari Blemish Balm NanoCream Yang Mengandung Vitamin C, Avobenzon, Dan Oktil Metoksisinamat. Tesis. Fakultas Farmasi, Universitas Sumatera Utara. 2020: 80.

Budiman. Uji Aktivitas Antioksidan Ekstrak Etanol Dan Sari Kulit Nanas (Ananas Comosus (L) Merr) Menggunakan Metode Radical Seavanser. Skripsi. Fakultas Farmas, Univeritas Muslim Nusantara Al Washliyah. 2020 : 41