A Systematic Review of Healthcare Professionals' Knowledge, Attitudes, and Practices Regarding Adverse Drug Reaction Reporting in Southeast Asia

Maria Sintia Manek; Chairun Wiedyaningsih; Dwi Endarti

doi:10.35451/c3t2v738

Authors

Maria Sintia Manek Universitas Gadjah Mada
Chairun Wiedyaningsih Universitas Gadjah Mada
Dwi Endarti Universitas Gadjah Mada

DOI:

https://doi.org/10.35451/c3t2v738

Keywords:

Adverse Drug Reaction (ADR), ADR reporting, patient safe, pharmacovigilance

Abstract

Background: Adverse drug reaction (ADR) reporting is a crucial component of ensuring patient safety within a pharmacovigilance system. ADR reporting plays an essential role in detecting, assessing, and preventing adverse effects related to medications in clinical practice. However, ADR reporting practices in Southeast Asia remain low. Objective: The purpose of this systematic review was to evaluate and synthesize evidence regarding healthcare professionals' knowledge, attitudes, and practices (KAP) regarding ADR reporting in Southeast Asia. This review aims to provide a comprehensive overview of current evidence and identify key gaps that may affect reporting practices. Methods: We conducted a literature search using PubMed, Scopus, EBSCOhost, and Web of Science for studies published between 2015 and 2025. Studies meeting the inclusion criteria were assessed for quality and analyzed using the PRISMA approach. This systematic review examined 16 studies from six Southeast Asian countries. Results: Most healthcare professionals have positive attitudes toward reporting ADRs, but knowledge varies, and actual reporting practices are low. Training, education, and incentive support were the most frequently cited factors facilitating reporting. Time constraints, unavailability of reporting forms, lack of awareness, uncertainty about the causality of drugs with adverse reactions, and lack of incentives were the main barriers to reporting. Conclusion: Healthcare professionals in Southeast Asia generally show positive attitudes toward ADR reporting, but knowledge remains varied, and reporting practices are low. Continuous education, system integration, and stronger national pharmacovigilance policies are needed to improve reporting.

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References

[1] McGettigan S, Curtin D, O’Mahony D. Adverse Drug Reactions in Multimorbid Older People Exposed to Polypharmacy: Epidemiology and Prevention. Pharmacoepidemiology 2024;3:208–22. https://doi.org/10.3390/pharma3020013.

[2] BPOM. Farmakovigilans (Keamanan Obat): Panduan Deteksi dan Pelaporan Efek Samping Obat untuk Tenaga Kesehatan. Jakarta: Badan Pengawas Obat dan Makanan; 2019.

[3] Giardina C, Cutroneo PM, Mocciaro E, et al. Adverse Drug Reactions in Hospitalized Patients: Results of the FORWARD (Facilitation of Reporting in Hospital Ward) Study. Front Pharmacol 2018;9:350. https://doi.org/10.3389/fphar.2018.00350.

[4] Montané E, Castells X. Epidemiology of drug‐related deaths in European hospitals: A systematic review and meta‐analysis of observational studies. Brit J Clinical Pharma 2021;87:3659–71. https://doi.org/10.1111/bcp.14799.

[5] BPOM, JICA. Modul Farmakovigilans Dasar. Jakarta: 2020.

[6] Alshabi AM, Shaikh MAK, Shaikh IA, et al. Knowledge, attitude and practice of hospital pharmacists towards pharmacovigilance and adverse drug reaction reporting in Najran, Saudi Arabia. Saudi Pharmaceutical Journal 2022;30:1018–26. https://doi.org/10.1016/j.jsps.2022.04.014.

[7] Asiamah M, Akuffo KO, Nortey P, et al. Spontaneous reporting of adverse drug reaction among health professionals in Ghana. Arch Public Health 2022;80:33. https://doi.org/10.1186/s13690-021-00783-1.

[8] Gidey K, Seifu M, Hailu BY, et al. Healthcare professionals knowledge, attitude and practice of adverse drug reactions reporting in Ethiopia: a cross-sectional study. BMJ Open 2020;10:e034553. https://doi.org/10.1136/bmjopen-2019-034553.

[9] Khan Z, Karatas Y, Hamid SM. Evaluation of health care professionals’ knowledge, attitudes, practices and barriers to pharmacovigilance and adverse drug reaction reporting: A cross-sectional multicentral study. PLoS ONE 2023;18:e0285811. https://doi.org/10.1371/journal.pone.0285811.

[10] Anbeo ZG, Abacioğlu N. A Systematic Review of Healthcare Professionals’ Knowledge, Attitudes, and Practices Regarding Adverse Drug Reaction Reporting in Ethiopia. Tjps 2023;20:198–209. https://doi.org/10.4274/tjps.galenos.2022.28034.

[11] García-Abeijon P, Costa C, Taracido M, et al. Factors Associated with Underreporting of Adverse Drug Reactions by Health Care Professionals: A Systematic Review Update. Drug Saf 2023;46:625–36. https://doi.org/10.1007/s40264-023-01302-7.

[12] García-Abeijon P, Costa C, Taracido M, et al. Factors Associated with Underreporting of Adverse Drug Reactions by Health Care Professionals: A Systematic Review Update. Drug Saf 2023;46:625–36. https://doi.org/10.1007/s40264-023-01302-7.

[13] N IO, Kp S, R JR, et al. Barriers to and facilitators of healthcare professionals in ADR reporting in a tertiary care hospital in India. BMC Health Serv Res 2025;25:166. https://doi.org/10.1186/s12913-024-12139-w.

[14] Hughes ML, Weiss M. Adverse drug reaction reporting by community pharmacists—The barriers and facilitators. Pharmacoepidemiology and Drug 2019;28:1552–9. https://doi.org/10.1002/pds.4800.

[15] Cheema E, Haseeb A, Khan TM, et al. Barriers to reporting of adverse drugs reactions: a cross sectional study among community pharmacists in United Kingdom. Pharm Pract (Granada) 2017;15:931–931. https://doi.org/10.18549/pharmpract.2017.03.931.

[16] Alwidyan T, Odeh M, Ibrahim AH, et al. Knowledge, attitude, and practice among community pharmacists toward adverse drug reaction reporting and pharmacovigilance: A nationwide survey. Exploratory Research in Clinical and Social Pharmacy 2025;18:100578. https://doi.org/10.1016/j.rcsop.2025.100578.

[17] Chan CL, Ang PS, Li SC. A Survey on Pharmacovigilance Activities in ASEAN and Selected Non-ASEAN Countries, and the Use of Quantitative Signal Detection Algorithms. Drug Saf 2017;40:517–30. https://doi.org/10.1007/s40264-017-0510-9.

[18] Mahfodz MM, Siddiqui S, Zainal H. Knowledge, attitude and practices about pharmacovigilance activities among hospital nurses: a multicentre cross-sectional survey. Journal of Research in Nursing 2024;29:259–74. https://doi.org/10.1177/17449871241232340.

[19] Khan Z, Karatas Y, Hamid SM. Evaluation of health care professionals’ knowledge, attitudes, practices and barriers to pharmacovigilance and adverse drug reaction reporting: A cross-sectional multicentral study. PLoS ONE 2023;18. https://doi.org/10.1371/journal.pone.0285811.

[20] Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 2021:n71. https://doi.org/10.1136/bmj.n71.

[21] Patey AM, Fontaine G, Francis JJ, et al. Healthcare professional behaviour: health impact, prevalence of evidence-based behaviours, correlates and interventions. Psychology & Health 2023;38:766–94. https://doi.org/10.1080/08870446.2022.2100887.

[22] Balan S. Knowledge, attitude and practice of Malaysian healthcare professionals toward adverse drug reaction reporting: a systematic review. International Journal of Pharmacy Practice 2021;29:308–20. https://doi.org/10.1093/ijpp/riab030.

[23] Roever L. Critical Appraisal of a Questionnaire Study. Evidence Based Medicine and Practice 2016;01. https://doi.org/10.4172/2471-9919.1000e110.

[24] Manek MS. Knowledge, Attitude, and Practice of Healthcare Professionals toward Adverse Drug Reaction Reporting in Southeast Asia: A Systematic Review 2025. https://doi.org/10.6084/m9.figshare.29998801.v1.

[25] Ghozali M, Murni IW. Knowledge and Attitude among Community Pharmacists regarding Pharmacovigilance – A Cross Sectional Survey. Indonesian J Pharm 2023;34:686–94. https://doi.org/10.22146/ijp.5814.

[26] Ulfah S, Ristiono H, Perwitasari DA. Pengetahuan dan Persepsi Apoteker Terhadap Sistem Pelaporan Monitoring Efek Samping Obat (MESO) di Apotek Wilayah Kota Yogyakarta. j ilm manuntung sains farm kesehat 2018;3:150–7. https://doi.org/10.51352/jim.v3i2.121.

[27] Wangge G, Akbar W. Knowledge, attitudes and practice of pharmacovigilance among health care professionals in Indonesia. Health Science Journal of Indonesia 2016;7:59–63. https://doi.org/10.22435/hsji.v7i1.5285.59-63.

[28] Zin RM, Hong YH, Ming LC, et al. Survey of knowledge, attitudes and practice regarding adverse drug reaction (ADR) reporting among community pharmacists in Selangor, Malaysia. Pharmacy Practice and Res 2019;49:234–9. https://doi.org/10.1002/jppr.1495.

[29] Ali RS, Ismail WI. Adverse Drug Reactions Reporting: Knowledge, Attitude and Practice Among Healthcare Providers at a Tertiary Hospital in Northern Region of Malaysia. Asian Journal of Medicine and Health Sciences 2021;4:214–27.

[30] Marquez M, Obra PE, Jr EP, et al. Assessment of Knowledge, Attitude, and Practices of Pharmacovigilance Among Hospital Pharmacists in Metro Manila, Philippines. De La Salle UniversityResearch Congress 2024:1–8.

[31] Carandang RR, Cao K, Jose NB, et al. Knowledge and Attitudes on Adverse Drug Reaction Reporting of Selected Hospital-based Health Practitioners in Manila, Philippines. Scholars Academic Journal of Pharmacy 2015;4:301–7.

[32] Worakunphanich W, Thongsombutpanitch F, Nilsonthi S, et al. Knowledge, attitude and practice of traditional medicine-related adverse drug reaction (ADR) reporting among hospital pharmacists and traditional medicine practitioners in Thailand. Pharm Sci Asia 2021;48:330–8. https://doi.org/10.29090/psa.2021.04.20.059.

[33] Nguyen-Thi H-Y, Do-Tran M-T, Ngoc TL, et al. Assessment of Knowledge, Attitude, and Practice in Adverse Drug Reaction Reporting of Healthcare Professionals in Vietnam: A Cross-Sectional Study. Hosp Pharm 2022;57:392–401. https://doi.org/10.1177/00185787211046864.

[34] Tran VD, Tran TNK, Vo QLD, et al. A Survey of Pharmacists and Other Healthcare Professionals in Vietnam: Factors Influencing Knowledge and Attitudes Toward Reporting Adverse Drug Reactions. Hosp Pharm 2024;59:56–69. https://doi.org/10.1177/00185787231186506.

[35] Da Costa J, Nosoongnoen W, Rungapiromnan W, et al. Knowledge, Attitude, Practice, and Barriers of Adverse Drug Reaction Reporting Among Healthcare Professionals in Timor‐Leste: A Cross‐Sectional Survey. Clinical Translational Sci 2025;18:1–14. https://doi.org/10.1111/cts.70134.

[36] Burud, I, Daher, AM, Din, HB, et al. Knowledge, attitudes, and practices related to adverse drug reaction reporting by healthcare professionals in a tertiary hospital in Malaysia. J Appl Pharm Sci 2021;11:79–87. https://doi.org/10.7324/japs.2021.1101011.

[37] Chen TS, Tan CP, Kwong KS, et al. knowledge-practices-attitudes-towards-adverse-drug-reaction-reporting-among-public-healthcare-professionals-in-west-pahang. Mal J Pharm 2023;9:29–36. https://doi.org/10.52494/meya2148.

[38] Srisuriyachanchai W, Cox AR, Jarernsiripornkul N. Exploring Healthcare Professionals’ Practices and Attitudes towards Monitoring and Reporting of Severe Adverse Drug Reactions. Healthcare 2022;10:1077. https://doi.org/10.3390/healthcare10061077.

[39] Jarernsiripornkul N, Kayrash S, Homket P, et al. A nationwide survey of methods and barriers to adverse drug reaction monitoring and reporting among hospital pharmacists in Thailand. International Journal of Pharmacy Practice 2023;31:625–32. https://doi.org/10.1093/ijpp/riad051.

[40] Khardali A. Exploring the knowledge, perception, and practice of community pharmacists in Saudi Arabia toward pharmacovigilance and adverse drug reaction reporting. A nationwide survey. Sci Rep 2024;14:4819. https://doi.org/10.1038/s41598-024-55664-8.

[41] Adedeji W, Adegoke A, Fehintola F. Adverse drug reactions reporting practice and associated factors among community health extension workers in public health facilities, Southwest, Nigeria. Pan African Medical Journal 2021;40. https://doi.org/10.11604/pamj.2021.40.165.28574.

[42] Putri RA, Ikawati Z, Rahmawati F, et al. An Awareness of Pharmacovigilance Among Healthcare Professionals Due to an Underreporting of Adverse Drug Reactions Issue: A Systematic Review of the Current State, Obstacles, and Strategy. Curr Drug Saf 2024;19:317–31. https://doi.org/10.2174/0115748863276456231016062628.