Overview of Antiepileptic Drug (AED) Use in Outpatient Patients at UNS Hospital
DOI:
https://doi.org/10.35451/5s852a48Keywords:
epilepsy, antiepileptic drugs, outpatient careAbstract
Epilepsy is a long-term disorder of the nervous system that requires long-term therapy using antiepileptic drugs (AEDs) to control seizures. The proper pattern of AED use plays a significant role in the effectiveness of treatment and patients’ overall well-being. This study aims to describe the use of antiepileptic drugs in outpatient patients at Universitas Sebelas Maret Hospital during the period of January-December 2024. This study used a non-experimental design with a descriptive approach, and data collection was conducted retrospectively through the review of medical records of epilepsy patients. From a total population of 1,236 medical record data, 303 samples were collected that satisfied the inclusion criteria. The analyzed data included patient characteristics based on gender and age, types of AED therapy, dosage, and usage rules. The study results show that outpatient epilepsy patients were predominantly female (53.14%) and the young adult age group 19-65 years (81.19%). The most commonly used therapy pattern was monotherapy, with Phenytoin 100 mg being the most frequently prescribed drug (28.38%), mainly at a dose of 1 tablet twice daily. Combination therapy was used in some patients with variations of two to four antiepileptic drugs. The conclusion of this study indicates that phenytoin is still the primary choice in the outpatient management of epilepsy at UNS Hospital, and reflects its role as a first-line drug effective in controlling various types of seizures. Predominated by females (53.14%) and the young adult age group aged 19-65 years (81.19%).
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References
[1] T. Pustaka Epilepsi Nur Sahira, “Galenical is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License,” 2024.
[2] J. Liu et al., “Status of epilepsy in the tropics: An overlooked perspective,” Mar. 01, 2023, John Wiley and Sons Inc. doi: 10.1002/epi4.12686.
[3] Fitriyani, F. Windiyani, T. Triwahyuni, and Dharmawita, “Tingkat Pengetahuan Tentang Penyakit Epilespi dan Pertolongan Pertama Saat Serangan Pada Mahasiswa Fakultas Kedokteran Universitas Malahayati Angkatan 2019 dan 2021,” Jurnal Ilmu Kedokteran dan Kesehatan, 2023.
[4] P. Puspa Devi, R. Wahyu Januarti, B. Ilmu Penyakit Saraf, and R. Hi Abdul Moeloek Provinsi Lampung, “Diagnosis dan Tatalaksana Epilepsi,” 2023.
[5] WHO. Epilepsy. 2024. Available from: https://www.who.int/news-room/fact sheets/detail/epilepsy
[6] D. Y. Haryanti, O. Maylanda Sundari, Ridho Firdayasano Madani, and R. Firdayasano Madani, “Peningkatan Kualitas Hidup Melalui Physical and Spiritual Treatment Pada Pasien Dengan Epilepsi : Studi Kasus,” Scientific Proceedings of Islamic and Complementary Medicine, vol. 1, no. 1, pp. 77–86, Aug. 2022, doi: 10.55116/spicm.v1i1.10.
[7] N. D. Lestari, S. Hastuti, and N. Astini, “Hubungan Lama Pengobatan Dan Jenis Obat Antiepilepsi Dengan Efek Samping Obat Pada Pasien Epilepsi Di Poliklinik Neurologi RSUDZA,” J. Med. Sci., vol. 3, no. 2, pp. 80–87, Feb. 2023, doi: 10.55572/jms.v3i2.98.
[8] T. Anindya, I. G. N. K. Budiarsa, and D. P. G. P. Samatra, “Karakteristik Pasien Epilepsi Rawat Jalan Di Poliklinik Saraf RSUP Sanglah Pada Bulan Agustus-Desember 2018,” Jurnal Medika Udayana, 2021.
[9] B.Nugraha, Santun Bhekti Rahimah, and Nurdjaman Nurimaba, “Gambaran Karakteristik Pasien Epilepsi di Rumah Sakit Al-Ihsan Tahun 2018-2019,” Semantic Scholar, Jan. 2021.
[10] S. Agustina, E. Wardani, and S. R. Jannah, “Quality of Life Epilepsy Patients’ in Indonesia,” 2023. [Online]. Available: www.multiresearchjournal.com
[11] NICE, “Epilepsies in children, young people and adults,” 2025. [Online]. Available: www.nice.org.uk/guidance/ng217
[12] Juliana, Mauliana, and Ajmain, “Analisis Penggunaan Obat Anti Epileps pada Pasien Rawat Jalan di RSUD Langsa,” Jurnal Intelek dan Cendikiawan Nusantara, 2025, [Online]. Available: https://jicnusantara.com/index.php/jicn
[13] H. Christiandari, M. Putri Pamungkas, and J. Yogi Hernawan, “Gambaran Penggunaan Obat Anti Epilepsi pada Pasien Dewasa di Instalasi Farmasi Rawat Jalan Rumah Sakit ‘JIH’ Yogyakarta Tahun Tahun 2023 Overview of Antiepileptic Drug Use in Adult Patients at the Outpatient Pharmacy of JIH Hospital, Yogyakarta Year 2023,” 2026. [Online]. Available: https://jurnal.itk-avicenna.ac.id/index.php/jkma/
[14] Khadra Karin Kamila, S. Maliawan, I. W. Niryana, and D. P. W. Wardhana, “Gambaran karakteristik pasien epilepsi di RSUP Prof. Dr. I.G.N.G. Ngoerah periode Januari – Desember 2023,” Intisari Sains Medis, vol. 16, no. 1, pp. 273–279, Mar. 2025, doi: 10.15562/ism.v16i1.2304.
[15] K. N. Fatmi, D. Roshinta, L. Dewi, and M. In’am Ilmiawan, “Hubungan Lama Menderita Frekuensi Kejang dan Keteraturan Konsumsi OAE Terhadap Fungsi Kognitif Pada Pasien Epilepsi,” vol. 4, p. 52, 2022.
[16] N. Faizi and S. Kazmi, “Universal health coverage - There is more to it than meets the eye,” J. Family Med. Prim. Care, vol. 6, no. 1, p. 169, 2017, doi: 10.4103/jfmpc.jfmpc_13_17.
[17] A. Suller Marti, E. Bellosta Diago, P. Vinueza Buitron, A. Velázquez Benito, S. Santos Lasaosa, and J. Á. Mauri Llerda, “Epilepsy in elderly patients: does age of onset make a difference?,” Neurología (English Edition), vol. 37, no. 3, pp. 171–177, Apr. 2022, doi: 10.1016/j.nrleng.2019.03.017.
[18] T. Hakami, “Neuropharmacology of Antiseizure Drugs,” Sep. 01, 2021, John Wiley and Sons Inc. doi: 10.1002/npr2.12196.
[19] A. Arica, A. Nurullah, L. Irfana, and N. Triastuti, “Perbedaan Efek Monoterapi dan Politerapi Obat Anti Epilepsi (OAE) terhadap Kekambuhan Kejang pada Pasien Epilepsi di Rumah Sakit Siti Khodijah Sepanjang,” 2024.
[20] G. Zheng et al., “An epidemiological survey of epilepsy in tropical rural areas of China,” Epilepsia Open, vol. 6, no. 2, pp. 323–330, Jun. 2021, doi: 10.1002/epi4.12476.
[21] C. E. Stafstrom and L. Carmant, “Seizures and epilepsy: An overview for Neuroscientists,” Cold Spring Harb. Perspect. Med., vol. 7, no. 5, pp. 1–19, 2015, doi: 10.1101/cshperspect.a022426.
[22] P. Brlek et al., “Exploring the Pharmacogenomic Map of Croatia: PGx Clustering of 522-Patient Cohort Based on UMAP + HDBSCAN Algorithm,” Int. J. Mol. Sci., vol. 26, no. 2, Jan. 2025, doi: 10.3390/ijms26020589.
[23] T. L. Schwinghammer, J. T. DiPiro, V. L. Ellingrod, and C. V DiPiro, “Pharmacotherapy Handbook Eleventh Edition,” 2015. [Online]. Available: https://www.facebook.com/groups/2202763316616203
[24] A. Safdar and F. Ismail, “A comprehensive review on pharmacological applications and drug-induced toxicity of valproic acid,” Feb. 01, 2023, Elsevier B.V. doi: 10.1016/j.jsps.2022.12.001.
[25] S. Agustina, J. S. Widjaja, and R. Puspasari, “Penggunaan Asam Valproat pada Pasien Epilepsi di Poliklinik Saraf Rumah Sakit Tingkat III Brawijaya Surabaya Periode Maret-Agustus 2021,” 2022.
[26] M. T. Utami et al., “Penggunaan Obat Anti Epilepsi di Rumah Sakit,” Jurnal Kesehatan Muhammadiyah, 2023.
[27] K. Kusumastuti, S. Gunadharma, and E. Kustiowati, Pedoman Tatalaksana Epilepsi. 2014.
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