The Role of Medication Adherence Companions on the Pharmacotherapy Outcomes of Hypertensive Patients at Bambanglipuro Community Health Center
DOI:
https://doi.org/10.35451/7r11af50Keywords:
Hypertension, Medication Adherence, \Medication Adherence Companion, Pharmacotheraphy outcomes, Primary Health CareAbstract
Hypertension is a prevalent chronic condition in primary health care, particularly among geriatric patients requiring long-term therapy. Despite the availability of antihypertensive medications, achieving target blood pressure remains challenging and is often associated with poor medication adherence. Medication Adherence Companions (PMO) may improve adherence and enhance therapeutic outcomes. This study aimed to analyze the role of PMO in the pharmacotherapy outcomes of hypertensive patients at the Bambanglipuro Community Health Center. This analytic observational study with a cross-sectional design involved 101 geriatric patients diagnosed with hypertension. Data were collected using structured questionnaires covering patient characteristics, presence of PMO, medication adherence, and blood pressure control status. Data were analyzed descriptively and using multivariate logistic regression with a significance level of p < 0.05. The results showed that 64.4% of patients had a PMO, and 54.5% demonstrated high adherence. Patients with high adherence were more likely to achieve controlled blood pressure. Multivariate analysis revealed that the presence of PMO significantly increased the likelihood of controlled blood pressure (AOR = 2.77; 95% CI: 1.29–5.95; p = 0.009). Combination therapy was also significantly associated with blood pressure control (AOR = 2.25; p = 0.047). These findings suggest that Medication Adherence Companions can support successful hypertension pharmacotherapy among geriatric patients in primary health care settings.
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[1] Saputra PBT, Izzati N, Rosita PE, Trilistyoati D, Isyroqiyyah NM, Hasna IH, et al. National Health Insurance Based Telemedicine Application for Hypertension Management in Primary Level of Health Facilities. JCMPHR. 2021 Jun 30;2(1):32. doi:10.20473/jcmphr.v2i1.25304
[2] Haris R. Tingkat Kepatuhan Penggunaan Obat Pada Pasien Hipertensi Di Instalasi Rawat Jalan Badan Layanan Umum Daerah (Blud) Rs Konawe. Inpharnmed. 2023 Aug 7;7(1):9. doi:10.21927/inpharnmed.v7i1.3096
[3] Kim D, Jeong H, Kim S, Shin H, Park K, Lee S, et al. Association between office visit intervals and long‐term cardiovascular risk in hypertensive patients. J of Clinical Hypertension. 2023 Aug;25(8):748–56. doi:10.1111/jch.14698
[4] Podzolkov VI, Bragina AE, Medvedev ID, Vetluzhskaya MV, Abramova AA, Loria IZh, et al. Compliance to treatment and its role in solving the problem of uncontrolled hypertension. Cardiovasc Ther Prev. 2023 May 8;22(4):3547. doi:10.15829/1728-8800-2023-3547
[5] Wulandari, A. S. (2020). Pengaruh konseling apoteker dengan media booklet terhadap tingkat pengetahuan dan perilaku pada pasien hipertensi di Puskesmas Purworejo. Indonesian Journal of Hospital Administration, 3(1), 36-44.
[6] Cushman WC. The Burden of Uncontrolled Hypertension: Morbidity and Mortality Associated With Disease Progression. J of Clinical Hypertension. 2003 May;5(3):14–22. doi:10.1111/j.1524-6175.2003.02464.x
[7] Kardas P, Bennett B, Borah B, Burnier M, Daly C, Hiligsmann M, et al. Medication non-adherence: reflecting on two decades since WHO adherence report and setting goals for the next twenty years. Front Pharmacol. 2024 Dec 23;15:1444012. doi:10.3389/fphar.2024.1444012
[8] Liang F, Su Z, Sheng W, Bishop A, Carlson B. Medication adherence management for in-home geriatric care with a companion robot and a wearable device. Smart Health. 2023 Dec;30:100434. doi:10.1016/j.smhl.2023.100434
[9] Wulandari A. Evaluasi Pemberian Dan Penggunaan Obat Antihipertensi Pada Pasien Lansia Di Puskesmas Sukarami Palembang. Inpharnmed. 2022 Jan 27;5(2):17. doi:10.21927/inpharnmed.v5i2.1919
[10] NR, Hiola F. Gambaran Penerapan Pelayanan Farmasi Klinik Di Puskesmas. delima. 2022 Feb 28;9(1):32–6. doi:10.31935/delima.v9i1.148
[11] H H, Bijal K N, Vv AK, P AS, S T, D R K. Impact of Pharmaceutical Care Interventions on Clinical outcome in Patients with Hypertension. Biosci, Biotech Res Asia. 2024 Mar 30;21(1):267–72. doi:10.13005/bbra/3223
[12] Florentina Y, Pramono JS, Amiruddin. The Relationship between PMO and the Level of Adherence to Taking Medication and Completeness of Treatment for Tuberculosis Patients at the UPT Puskesmas Long Me Sangat. FJST. 2023 Oct 3;2(9):2517–26. doi:10.55927/fjst.v2i9.5936
[13] Alfian SD, Van Boven JFM, Iskandarsyah A, Abdulah R, Hak E, Denig P. Process Evaluation of Implementing a Pharmacist-Led Intervention to Improve Adherence to Antihypertensive Drugs Among Patients with Type 2 Diabetes in Indonesian Community Health Centers. Front Pharmacol. 2021 May 5;12:652018. doi:10.3389/fphar.2021.652018
[14] Arshed M, Mahmud A, Minhat HS, Lim PY, Zakar R. Effectiveness of a Multifaceted Mobile Health Intervention (Multi-Aid-Package) in Medication Adherence and Treatment Outcomes Among Patients With Hypertension in a Low- to Middle-Income Country: Randomized Controlled Trial (Preprint) [Internet]. JMIR mHealth and uHealth; 2023 [cited 2026 Mar 4]. Available from: http://preprints.jmir.org/preprint/50248 doi:10.2196/preprints.50248
[15] Rigoni CC, Brito ESD, Alano GM, Dayani Galato. Pharmacotherapy review: a proposal to improve medication adherence among hypertensive patients [Internet]. SciELO journals; 2021 [cited 2026 Mar 4]. p. 65913 Bytes. Available from: https://scielo.figshare.com/articles/dataset/Pharmacotherapy_review_a_proposal_to_improve_medication_adherence_among_hypertensive_patients/14290765 doi:10.6084/M9.FIGSHARE.14290765
[16] Crawshaw J. Supporting medication adherence for long-term conditions: challenges and opportunities to move the field forward. Eur Health Psych. 2025 Aug 25;24(2). doi:10.62696/g8yfjk74
[17] Schulz R, Beach SR, Czaja SJ, Martire LM, Monin JK. Family Caregiving for Older Adults. Annu Rev Psychol. 2020 Jan 4;71(1):635–59. doi:10.1146/annurev-psych-010419-050754
[18] Zhang X, Wu Y. Roles and contributions of companions in healthcare professional-older patient interaction: A systematic review. Patient Education and Counseling. 2025 Jan;130:108455. doi:10.1016/j.pec.2024.108455
[19] Nisa FM, Retnowati E, Kurniawan G. Relationship Between Geriatric Patient Characteristics and Adherence to Outpatient Antihypertensive Therapy in Hospitals. AHR. 2025 Aug 16;3(2):562–76. doi:10.60079/ahr.v3i2.596
[20] Wahyu L, Kusumastuti NA, Idu CJ. Hubungan Dukungan Keluarga dengan Kepatuhan Minum Obat Antihipertensi di Puskesmas Tanah Tinggi Tangerang. Mal Health Stu J. 2023 Jun 24;3(6):1751–9. doi:10.33024/mahesa.v3i6.10526
[21] Mahfud M, Barasila B, Indrayani S. Dukungan sosial berhubungan dengan self care management pada lansia hipertensi di Puskesmas Sedayu II. Dinamika Kesehatan: Jurnal Kebidanan dan Keperawatan. 2019;10(2):700–712.
[22] Alfarisi R, Diksa PAT. Analisis Perbedaan Tekanan Darah Berdasarkan Tingkat Kepatuhan Minum Obat pada Kelompok Geriatri Penderita Hipertensi. Mal Health Stu J. 2023 Dec 1;3(12):4047–57. doi:10.33024/mahesa.v3i12.12162
[23] Brigita M, Hijrawati H, Artama S. Characteristics and adherence of the elderly to the management of hypertension treatment. fulltext PDF. 2023 Dec 31;12(2):435–44. doi:10.35816/jiskh.v12i2.1114
[24] Kartika D, . S, Atika N. Evaluation Of The Use Of Antihypertension Drug In Hypertension Patients At The Grandmed Lubuk Pakam Hospital Installation In 2022. JFM. 2023 Apr 30;5(2):198–205. doi:10.35451/jfm.v5i2.1613
[25] Sandhya Rani M, Ramesh Palabindela, Penupothu Sree Nagamani, Naveen Choudary G. Assessing adherence to hypertension medications and its impact on blood pressure control: A community-based observational study. Asian J Med Sci. 2023 Dec 1;14(12):61–6. doi:10.3126/ajms.v14i12.57843
[26] Anggraeni R, Marbun RAT, Siagian HS, Lubis AH. The Influence of Abdominal Circumference and Body Mass Index On Hypertension. JFM. 2024 Oct 31;7(1):68–72. doi:10.35451/jfm.v7i1.2358
[27] Odubanjo OA, Tipping B, Greenstein LS. Medication adherence in geriatric patients attending medical outpatient department. S Afr Fam Pract. 2024 Oct 25;66(1). doi:10.4102/safp.v66i1.6011
[28] Bhuiya NMMA, Caballero J, Young HN, Villa Zapata L. Trends and Predictors of Antihypertensive Medication Adherence in Commercially Insured Adults under 65 (2018–2023). J of Clinical Hypertension. 2025 Aug;27(8):e70108. doi:10.1111/jch.70108
[29] Serina PT, Bounds M, Dandapani H, Carnes TC, Linnebur SA, Gomez Picazo J, et al. Could digital pills improve medication adherence in persons living with dementia? A qualitative study. J American Geriatrics Society. 2024 Aug;72(8):2581–4. doi:10.1111/jgs.18932
[30] Kröger E, Tatar O, Vedel I, Giguère AMC, Voyer P, Guillaumie L, et al. Improving medication adherence among community-dwelling seniors with cognitive impairment: a systematic review of interventions. Int J Clin Pharm. 2017 Aug;39(4):641–56. doi:10.1007/s11096-017-0487-6
[31] Taufiqurrahman A, Alexander E. Effectiveness of Combination Antihypertensive Therapy for Controlling Blood Pressure in the Elderly. Media Health Res. 2025 Aug 30;3(2):32–40. doi:10.70716/mohr.v3i2.203
[32] Cherfane M, Vallée A, Kab S, Salameh P, Goldberg M, Zins M, et al. Risk factors for uncontrolled blood pressure among individuals with hypertension on treatment: the CONSTANCES population-based study. International Journal of Epidemiology. 2024 Feb 14;53(2):dyae027. doi:10.1093/ije/dyae027
[33] Ryabikov AN, Mazdorova EV, Mazurenko ES, Malyutina DV, Shapkina MYu. Analysis of 17 Factors Potentially Related to Hypertension Control in the Siberian Urban Sample. Kardiologiia. 2025 Sep 10;65(8):31–41. doi:10.18087/cardio.2025.8.n2903
[34] Oseni T, Emonriken A, Ahmed S, Dic-Ijiewere M. Determinants of Blood Pressure Control among Hypertensive Patients Attending a Rural Teaching Hospital in Southern Nigeria. Nigerian Journal of Clinical Practice. 2023 Mar;26(3):260–6. doi:10.4103/njcp.njcp_1678_21
[35] Apristina A, Nurinda E, Kusumawardani N, Yugistyowati A, Dwinta E. Analisis hubungan tingkat kepatuhan penggunaan obat terhadap luaran klinis pasien prolanis diabetes melitus dengan hipertensi di Puskesmas Minggir pada masa pandemi COVID-19. Pharmaceutical Journal of Indonesia. 2023;8(2):149–156.
[36] Syah R. Management of hypertensive crisis emergencies in primary healthcare facilities: challenges and solutions. J Farm Medistra. 2024;6(2):205–209. doi:10.35451/jfm.v6i2.2508.
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Copyright (c) 2026 Diki Aprianto A, Eva Nurinda, Ari Susiana Wulandari, Ade Puspitasari, Ifa Aris Suminingtyas

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