Testing the Activity of Peel-Off Nanoparticle Preparation From Paper Flower Extract (Bougainvillea spectabilis Wild.) as an Antioxidant
DOI:
https://doi.org/10.35451/jfm.v9i1.3882Keywords:
extract, paper_flower, nanoparticles , antioxidant , peel offAbstract
Background: Bougainvillea flowers (Bougainvillea spectabilis Willd.) contain bioactive compounds, including flavonoids, alkaloids, phenolics, saponins, tannins, and terpenoids, which have potential antioxidant properties. Bougainvillea flower extract has been reported to exhibit strong antioxidant activity, with an IC₅₀ value of 82.36 µg/mL. The incorporation of bougainvillea flower extract nanoparticles into peel-off gel masks offers a promising innovation for developing natural antioxidant cosmetic products. Objective: To formulate and evaluate the physical characteristics, stability, preliminary safety, and antioxidant activity of peel-off gel masks containing bougainvillea flower extract nanoparticles. Methods: This experimental study involved extraction by maceration using ethanol, nanoparticle preparation through the chitosan–NaTPP ionic gelation method, and formulation into peel-off gel masks. Evaluations included nanoparticle characterization, physical quality assessment, stability testing, irritation testing, and antioxidant activity determination using the DPPH method. Results: The extraction process yielded 38.13% extract. The nanoparticles exhibited a particle size of 168.54 ± 4.27 nm, a polydispersity index of 0.286 ± 0.019, and a zeta potential of +27.35 ± 1.42 mV. All formulations (F1–F3) demonstrated satisfactory physical characteristics and stability, with no irritation observed under the testing conditions. Formulation F1 exhibited the highest antioxidant activity, with an IC₅₀ value of 16.73 ppm, followed by F2 at 20.93 ppm. All formulations were classified as having very strong antioxidant activity. Conclusion: Bougainvillea flower extract nanoparticles were successfully formulated into peel-off gel masks with satisfactory physical characteristics and very strong antioxidant activity. Formulation F1 demonstrated the highest antioxidant activity and shows potential for development as a natural antioxidant cosmetic product, although further safety and efficacy studies are required.
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1. Cahyani, A.N., Feri, K.R. dan Ngafifah. 2025. Formulasi Serum Nanopartikel Ekstrak Etanol Kulit Buah Kakao (Theobroma cacao L.) Sebagai Antioksidan. Jurnal Ilmiah Farmasi Parapemikir, 14(1): 8 – 17.
2. A. N. Pratama and H. Busman. 2020. Potensi Antioksidan Kedelai (Glycine Max L) Terhadap Penangkapan Radikal Bebas. Jurnal Ilmu Kesehatan Sandi Husada, 11(1): 497–504.
3. Ginaris, R.P. 2023. Uji Aktivitas Masker Wajah Peel-Off Dari Ekstrak Bunga Krisan (Chrysanthemum cinerariaefolium (Trevir.)Vis. Sebagai Antioksidan. Jurnal Kesehatan Tujuh Belas, 4(2): 248 – 253.
4. Yuliani, N.N., Siswandono., Tristiana, E., Jefrin, S., Muhamad, S.P., Upa. 2024. Antioxidant activity of Bougainvillea spectabilis ethanol extracts as an aryl hydrocarbon inhibitor. Pharmacy Education, 24(3): 395 – 400. https://doi.org/10.46542/pe.2024.243.395400.
5. Altundag, E.M., Selma, U., Cahit, O., Ayse, M.Y. 2025. Chemical Characterization Antioxidant Potential and Cytotoxicity of Bougainvillea spectabilis Wild. Flowers Cultivated in Northern Cyprus. Natureportfolio Scientific reports, 15: 38056.https://doi.org/10.1038/s41598-025-21892-9.
6. Permadi Y.W., Wulan, A.N., Wirasti., Tri, S.W. 2022. Uji Antioksidan Pada Sediaan Peel Off Nanopartikel Ekstrak Terung Belanda (Solanum betaceum). Prodising 16thUrecol: Seri MIPA dan Kesehatan, (1838 – 1847).
7. Ningrum, W.A., Wirasti, Yulian, W.P., Fida, F.H. 2021. Uji Sediaan Lotion Nanopartikel Ekstrak Terong Belanda Sebagai Antioksidan. Jurnal Ilmiah Kesehatan, 14(1): 99 – 104.
8. Utiah, S. 2016. Formulasi dan Evaluasi Sediaan Lipstik Dengan Pewarna Alami Dari Ekstrak Bunga Kertas (Bougainvillea spectabilis). Skripsi. Fakultas Olahraga dan Kesehatan, Universitas Negeri Gorontalo.
9. Sihotang, H.S., Titin, S., Marvel, R.S. 2025. Formulasi Liquid Blush On Dari Ekstrak Bunga Kertas, Bunga Mawar dan Bit Sebagai Pewarna Alami. Jurnal Penelitian Kesehatan Suara Forikes, 15(4): 752 – 757. http://dx.doi.org/10.33846/sf15438.
10. Yuniarsih, N., Hidayah, H., & Andhini, A. (2023). Formulasi dan Uji Antioksidan Serum Spray Gel Ekstrak Etanol Bunga Kertas. Jurnal Buana Farma, 3(3), 83–89. https://doi.org/10.36805/jbf.v3i3.808.
11. Apriliani, T., Shafa, N., Rina, H.P. 2024. Aktivitas Ekstrak Etanol Bunga Kertas (Bougainvillea spectabilis) Terhadap Pertumbuhan Candida albicans. Jurnal Biologi dan Pendidikan Biologi Biosfer, 9(2): 199 – 205.
12. Sulastri T, Sunyoto M, Suwitono MR, Levita J. 2022. The effect of red ginger bread consumption on the physiological parameters of healthy subjects. Jurnal Adv Pharm Educ Res;12(3):28–35.
13. Shoviantari, F., Rachelda, B.A.M., Ratih, N.R. 2024. Uji Aktivitas Antibakteri Dan Antioksidan Gel Ekstrak Etanol Bunga Kertas (Bougainvillea glabra). Jurnal Ilmu Farmasi Dan Farmasi Klinik (JIFFK), 21(1): 95 – 105.
14. Sabdoningrum, E.K. Sri, H., Sri, C. Soehartono. 2021. Characterization and Phytochemical Screening of Meniran (Phyllanthus niruri Linn) Extract’s Nanoparticles Used Ball Mill Method. Jurnal Pharmacogn J, 13(6): 1568 – 1572.
15. Ghiffari HD, Utami RT, Budiasih S, Julianto T, Putri RM. Formulasi Dan Uji Stabilitas Lip Cream Kombinasi Ekstrak Kulit Buah Terong Belanda (Solanum betaceum) Dan Ekstrak Umbi Bit (Beta vulgaris L) Abstrak menimbulkan masalah serius karena dapat berupa lip cream serta uji stabilitas fisika dan cream yang di. J Farm Higea. 2024;16(2):153–60.
16. Baihaqi, B., Hakim., Syahirman., Nuarida, N., M.Mandasan., Mahfuzah, M., 2022. Pemgaruh Konsentrasi Pelarut dan Waktu Maserasi Terhadap Ekstraksi Oleoserin Jahe Merah. Jurnal Tekonologi Pengabdian Pertanihan, 4(2): 48 – 52.
17. Apriliani, T., Noer, S., Pratiwi, R.H. 2024. Aktivitas Ekstrak Etanol Bunga Kertas (Bougainvillea spectabilis) terhadap Pertumbuhan Candida albicans. Biosfer, Jurnal Biologi dan Pendidikan Biologi, 9(2): 199 – 205.
18. Simatupang, R. A.L., Tombuku, J.L., Pareta, D.N., Lengkey, Y.K. 2021. Uji Aktivitas Antioksidan Ekstrak Bunga Bougenville Bougainvillea glabra Sebagai Antioksidan. Jurnal Biofarmasetikal Tropis, 4(1) : 30 – 39.
19. Guge, S.R.S., Lukum, A., Kunusa, W.R. 2024. Pembuatan Nano-Kitosan Menggunakan Metode Gelasi Ionik. Jamb.J.Chem, 6(1) : 1 – 8.
20. Bavel, N. V., et al. (2023). A simple method for synthesis of chitosan nanoparticles with tripolyphosphate as cross-linker and characterization of their physicochemical properties. International Journal of Molecular Sciences.
21. Bugnicourt, L., & Ladavière, C. (2016). Interests of chitosan nanoparticles ionically cross-linked with tripolyphosphate for biomedical applications. Progress in Polymer Science, 60, 66–83.
22. Gutiérrez-Ruíz, S. C., et al. (2024). Optimize the parameters for the synthesis by the ionic gelation method of chitosan nanoparticles. Journal of Nanobiotechnology, 22, 1–15.
23. Abdel-Hafeez, S. M., & Husseiny, M. I. (2022). Physicochemical, thermal, and morphological properties of chitosan nanoparticles produced by ionic gelation. Polymers, 14(21), 4594. https://doi.org/10.3390/polym14214594.
24. Yildiz, H., & Karatas, N. (2024). Optimize the parameters for the synthesis by the ionic gelation technique, purification, and freeze-drying of chitosan-sodium tripolyphosphate nanoparticles for biomedical purposes. Journal of Biological Engineering, 18, Article 11. https://doi.org/10.1186/s13036-024-00403-w.
25. Larasati, D., Fatkhunisa, W., Hernowo, B., Zulfaidah, N.T. 2024. Inovasi Pemanfaatan Daun Sirsak Dalam Formulasi Masker Gel Peel Off Sebagai Sediaan Kosmetik.Journal of Pharmaceutical, 2(2): 12 – 18.
26. Ramadhani, S., Meirista, I., Mariska, R.P. 2025. Optimasi Gelling Agent PVA dan HPMC Masker Peel Off Ekstrak Etanol 70% Daun Ketepeng Cina (Cassia alata L.) Sebagai Sediaan Anti Acne. Jurnal Kesehatan Masyarakat (Prepotif), 9(1): 535 – 540.
27. Kartika, S.D., Panji, R.S., Cikra, I.N.H.S., Nunik, D.K. 2021. Formulasi Sediaan Masker Gel Peel Off Ekstrak Temu Putih (Curcuma zedoaria) Sebagai Anti Jerawat. Seminar Nasional Pendidikan Biologi Dan Saintek, (6): 351 - 358.
28. Yuliana, T.P., Kusumo, R.H., & Hariadi, P. 2023. Formulasi Sediaan Masker Gel Peel Off Kombinasi Ekstrak Daun Kelor (Moringa oliefera Lam.) Dan Cangkang Telur Sebagai Anti Jerawat. Jurnal Farmasi Klinis dan Sains Bahan Alam, 3(1) : 9 – 17.
29. Safitri, C.I.N.H. 2024. Formulasi dan Uji Mutu Fisik Masker Gel Peel Off Kombinasi Sisik Ikan Bandeng Dan Kulit Jeruk Nipis. Jurnal Ilmu Farmasi dan Kesehatan, 2(2): 30 -39. https://doi.org/10.59841/an-najat.v2i2.1088.
30. Jasmine, P., Irtawidjajanti, S., Ambarwati, N.S.S. 2026. Formulasi dan Evaluasi Fisik Masker Gel Peel Off Ekstrak Daun Mint (Mentha piperita L.). Jurnal Ilmiah Wahana Pendidikan, 12(7B) : 161 – 173. https://jurnal.peneliti.net/index.php/JIWP/article/view/13590.
31. Hasibuan, N.E., Azka, A., Basri, B., & Mujiyanti, A. 2024. Aktivitas Antioksidan Dan Karakteristik Masker Gel Peel Off Dari Ekstrak Daun Mangrove (Avicennia marina). Jurnal Pengolahan Hasil Perikanan Indonesia, 27(9) : 872 – 883. https://doi.org/10.17844/jphpi.v27i9.52083.
32. P. Elsner, Bioengineering of the Skin: Methods and Instrumentation, Boca Raton: CRC Press, 2020, pp. 45-52.
33. Adhayanti, E., & Darsini, N. L. A. N. N. (2022). Formulasi Sediaan Masker Gel Peel Off Ekstrak Daun Kelor (Moringa oleifera Lam.) dan Minyak Atsiri Serai Wangi (Cymbopogon nardus L. Rendle). Metamorfosa: Journal of Biological Sciences, 9(1), 101.
34. Putri, M., Capritasari, R., Wijayatri, R., Ningrum, Y.A., Pradani, M.P.K. 2024. Formulasi Dan Uji Aktivitas Antioksidan Sediaan Masker Gel Peel Off Ekstrak Etanol Daun Pegagan (Centella asiatica (L.) Urban). Borneo Journal of Pharmascientech, 8(2): 194 – 206. https://doi.org/10.51817/bjp.v7i1.612.
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Copyright (c) 2026 Dina Maya Syari, Hartika Samgryce Siagian, Sri Rezeki Samosir, Windi Agustina
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