Formulation and Evaluation of an Anti-Acne Toner Preparation Containing Red palm oil (Red palm oil) for Antibacterial Activity Against Propionibacterium acnes
DOI:
https://doi.org/10.35451/jfm.v9i1.3915Keywords:
Anti-Acne Toner, Red palm oil, Propionibacterium Acnes, Antibacterial ActivityAbstract
Background: Acne is a common skin disorder associated with the growth of Propionibacterium acnes. Red palm oil derived from the fruit contains bioactive compounds with potential antibacterial properties, making it a promising active ingredient for anti-acne toner formulations. Aim: to develop an anti-acne toner containing Red palm oil, evaluate its physical characteristics, and determine its antibacterial activity against Propionibacterium acnes. Methods: This study was an experimental laboratory research using a quantitative approach. Four formulations were prepared, namely F0 (base), F1 (1%), F2 (3%), and F3 (5%) Red palm oil. The formulations were evaluated for organoleptic properties, homogeneity, pH, adhesion, stability using the cycling test, skin irritation, and hedonic acceptance. Antibacterial activity was determined using the disc diffusion method. Results: In conclusion, Red palm oil derived from the fruit can be successfully formulated into an anti-acne toner that meets the required physical evaluation parameters, is stable and safe for use, and exhibits antibacterial activity against Propionibacterium acnes. In conclusion, red palm oil derived from the fruit can be successfully formulated into an anti-acne toner that meets the required physical evaluation parameters, is stable and safe for use, and exhibits antibacterial activity against Propionibacterium acnes.
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1. Nasikin, M. A., & Achmad Ridho, Regia Desty Rakhmayanti, A. N. H. (2024). Formulation and Testing of Antibacterial Activity of Facial Toner Preparations Chinese Belt Leaf Extract (Peperomia pellucida L. Kunth) Against the Bacteria Propionibacterium acnes. Journal of Local Therapy, 3(2), 50–61.
2. Musniati, Tatiana Siska Wardani, D. R. U. (2024). Formulasi dan Uji Fisik Sediaan Face Toner Ekstrak Etanol Daun Sirih Merah (Piper crocotum) terhadap Propionibacterium acnes. SYNTAX IDEA, 6(Oktober), 4–6.
3. Saputri, B. B., & Astutik, S. (2024). Pengaruh Berbagai Konsentrasi Ekstrak Rumput Laut Merah (Eucheuma spinosum) Terhadap Zona Hambat Pertumbuhan Bakteri Propionibacterium acnes. Jurnal Ilmiah Pendidikan Dasar, 9(4), 162–173.
4. Harefa, K., Aritonang, B., & Ritonga, A. H. (2022). Aktivitas Antibakteri Ekstrak Etanol Kulit Markisa Ungu (Passiflora edulis Sims) Terhadap Bakteri Propionibacterium acnes. Jurnal Multidisiplin Madani, 2(6), 2743–2758.
5. Tarigan, I. L., et al. (2022). Development of Red palm oil Products as Functional and Nutraceuticals Food and Cosmetics. Khazanah Intelektual, 6(2), 1395–1414.
6. Jusman, J., Syamsuddin, S., & Aisyah, N. (2021). Subtitusi Red palm oil (RPO) sebagai Alternatif Pangan Fungsional Kaya Betakarotein. Rafflesia Journal of Natural and Applied Sciences, 1(2), 69–76.
7. Rasdiana, R., et al. (2023). Analisis Profil Karotenoid dan Beta-Karoten pada Fraksi Minyak Makan Merah Kelapa Sawit. Jurnal Teknologi Industri Pertanian, 17(2), 89–97.
8. Aspadiah, V., Zubaydah, W. O. S., Muliadi, R., Anwar, I., & Jumilta. (2024). Formulasi, Evaluasi dan Uji Iritasi Sediaan Toner Niacinamide. Lansau: Jurnal Ilmu Kefarmasian, 2(1), 1–10.
9. Khaira, Z., Monica, E., & Yoedistira, C. D. (2022). Formulasi dan uji mutu fisik sediaan serum mikroemulsi ekstrak biji melinjo Gnteum gnemon L. Sainsbertek jurnal ilmiah sains & teknologi, 3(1), 299-309.
10. Noor, M., Malahayati, S., & Nastiti, K. (2023). Formulasi dan Uji Stabilitas Sediaan Toner Wajah Ekstrak Buah Pare (Momordica charantia L.) sebagai Anti Jerawat dengan Variasi Surfaktan. Jurnal Riset Kefarmasian Indonesia, 5(1), 133–144.
11. BR, T. B., & SHANIA, R. (2025). FORMULASI DAN UJI AKTIVITAS ANTIBAKTERI DARI SEDIAAN GEL HAND SANITIZER EKSTRAK ETANOL BUNGA BELIMBING WULUH (AVERRHOA BILMBI LINN) TERHADAP BAKTERI STAPHYLOCOCCUS AUREUS. JURNAL FARMANESIA Учредители: Universitas Sari Mutiara Indonesia, 11(2), 86-94.
12. Mardiyah, M., Khairunisa, L., Nurjanah, V. O., Maulud, D., Putri, S. A., Ambardhani, N., & Syaputri, F. N. (2024). Uji Aktivitas Antioksidan Nano Spray Gel Ekstrak Daun Singkong (Manihot esculenta). Majalah Farmasetika, 9(5), 489-505.
13. SITUMORANG, Novidawati Boru, et al. Test Of Effect Kedondong Leaf Ethanol Extract (Spondias Dulcis) On Staphylococcus Aureus Bacteria. JURNAL FARMASIMED (JFM), 2023, 5.2: 166-171.
14. KARTIKA, Dewi; MARBUN, Romauli Anna Teresia; DEWI, Ayu Puspita. ANTIBACTERIAL ACTIVITY OF KERSEN LEAF EXTRACT (MUNTINGIA CALABURA L) AGAINST STAPHYLOCOCCUS AUREUS. JURNAL FARMASIMED (JFM), 2022, 4.2: 59-63.
15. Ariyanti, N., Lestari, D., & Rahmawati, S. (2024). Mekanisme Senyawa Metabolit Sekunder Bahan Alam sebagai Agen Antibakteri Topikal. Jurnal Sains Farmasi & Klinis, 11(1), 45–56.
16. Marbun, R.A.T., 2020. Uji aktivitas ekstrak daun pirdot (Sauraia vulcani Korth.) terhadap pertumbuhan Candida albicans secara in vitro. Jurnal Bios Logos, 11(1), p.1.
17. Siregar, S., Indriani, I., Rizky, V. V. A., Krisdianilo, V. V., & Marbun, R. A. T. (2020). Perbandingan aktivitas antibakteri infusa daun jeruk nipis (Citrus aurantifolia) dan daun jeruk purut (Citrus hystrix) terhadap bakteri Escherichia coli. Jurnal Farmasimed (JFM), 3(1), 39-46.
18. Rastogi, V., Krishnanand, S., Panwar, R. B., Chacko, K. M., Prem, R., Vijay, C., & Agiwal, V. (2022). Quality analysis, anti-bacterial activity and chemical characterization of ethnobotanical (Hawan) medicinal fumes. Interdisciplinary Journal of Yagya Research, 5(1), 01-19.
19. Utami, S. T., Paramita, N. S. P., Agustina, K., Prayoga, M. B., Maulidia, F. N., Apsari, C. N., ... & Atikana, A. (2024). Identification of Secondary Metabolites Derived from Aaptos spp. and Their Antibacterial Activity. Indonesian Journal of Pharmacy/Majalah Farmasi Indonesia, 35(2), 325.
20. Marin-Tinoco, R. I., Ortega-Ramírez, A. T., Esteban-Mendez, M., Silva-Marrufo, O., Barragan-Ledesma, L. E., Valenzuela-Núñez, L. M., ... & Navarrete-Molina, C. (2023). Antioxidant and antibacterial activity of Mexican oregano essential oil, extracted from plants occurring naturally in semiarid areas and cultivated in the field and greenhouse in Northern Mexico. Molecules, 28(18), 6547.
21. Camila, D., Ulfa, A. M., & Elsyana, V. (2022). Formulasi Dan Uji Antibakteri Sediaan Sabun Cair Antiseptik. Jurnal Ilmu Kedokteran dan Kesehatan, 9(2), 710.
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Copyright (c) 2026 Ernawatty Ginting, Shahira Yasmin, Kanne Dachi, Sudewi
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