2026-04-04T02:14:58Z https://ejournal.medistra.ac.id/index.php/JFM/oai

oai:ejournal.medistra.ac.id:article/86 2023-11-23T04:28:24Z JFM:YRS

PENGARUH EKSTRAK UMBI BAWANG PUTIH DAN UMBI BAWANG MERAH TERHADAP LUKA BAKAR PADA KELINCI Barus, Bunga Rimta Lestari, Indah Estrak Bawang Putih Ekstrak Bawang Merah Luka Bakar Luka Bakar Derajat II Burns are one of the most common types of injuries in the community. The content of alliin in garlic (Allium sativum L) and onion (Allium cepavarascalonicum) is believed to help heal burns, with its biological activity as anti-aggregation of platelet cells, boost fibrinolysis and as an anti-bacterial. Objective of this research is to know the effect of gaelic extract (Allium sativum L) and red onion (Allium cepa var ascalonicum) to burn on rabbit.The methodology of this research is an experimental method based on a complete randomized design.sample used in this research and onion bulbs taken in Berastagi Subdistrict, Karo Regency, North Sumatera Province.Result of this research show that subjects of Garlic extract with 15% concentration gave the fastest healing effect on 7th day, 10% and 5% dose gave healing effect on the 8th day. Giving onion bulbs extract at 15%, 10% and 5% concentration gave healing effect of burn on 8th day. The healing of burns in the comparison group was on the 8th day while the longest burn healing in the control group was on the 10th day. Conclusion is an effect that can be found in the extract of garlic and onion extract to the burn on the rabbit. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2018-10-15 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/86 10.35451/jfm.v1i1.86 JURNAL FARMASIMED (JFM); Vol. 1 No. 1 (2018): Jurnal FARMASIMED (JFM); 1-5 Jurnal FARMASIMED (JFM); Vol 1 No 1 (2018): Jurnal FARMASIMED (JFM); 1-5 2655-0814 10.35451/jfm.v1i1 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/86/26 10.35451/jfm.v1i1.86.g26 Copyright (c) 2018 Bunga Rimta Barus, Indah Lestari

oai:ejournal.medistra.ac.id:article/87 2023-11-23T04:28:24Z JFM:YRS

Formulasi Sediaan Pengharum Ruangan Dari Minyak Melati Dengan Minyak Akar Wangi Sebagai Pengikat Surbakti, Christica Illsanna Swadana, Eka Gel Pengharum Ruangan Minyak Akar Wangi Minyak Melati Natrium alginate Fragrance is a growing product today, one of which is in the form of air freshener. Fragrance materials used in the product are divided into two types, namely synthetic deodorizer and natural fragrance. Synthetic deodorizer has a sharper fragrance, so it can cause dizziness, while natural fragrance has a softer fragrance.The selection of gel form is because it is more durable and practical in use. Purpose: The purpose of this study for formulate carrageenan and natrium alginat as a base of gel air freshener, for formulate jasmine oil with the various concentration as a fragrance, for formulate vetiver oil with the various concentration as a fixative Methods: This research consist of three stages. First, looking for the best base of gel air freshener by using combination of carrageenan and natrium alginat with three percent concentration at many comparison, they are 70:30, 60:40, 40:60, 30:70. And then, looking for the best fragrance by using rose oil at many concentration. They are 1%, 2%, 4% dan 6%. And then, looking for the best concentration of vetiver oil that can endurance the fragrance of jasmine oil for the longest time on storage in different place, such as AC room and fan room. Results: The results of this study indicate that the best gel formulation are mixture carrageenan and natrium alginat with comparison 70:30. The best fragrance of jasmine oil is eight percent concentration. The longest fragrance endurance is vetiver oil with one percent concentration. Conclusion: Combination of carrageenan and natrium alginat with comparison 70:30 can be formulated as a base of gel air freshener, the best concentration of jasmine oil is four percent, and the best concentration of vetiver oil is one percent Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2018-10-15 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/87 10.35451/jfm.v1i1.87 JURNAL FARMASIMED (JFM); Vol. 1 No. 1 (2018): Jurnal FARMASIMED (JFM); 6-10 Jurnal FARMASIMED (JFM); Vol 1 No 1 (2018): Jurnal FARMASIMED (JFM); 6-10 2655-0814 10.35451/jfm.v1i1 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/87/27 10.35451/jfm.v1i1.87.g27 Copyright (c) 2018 Christica Illsanna Surbakti, Eka Swadana

oai:ejournal.medistra.ac.id:article/88 2023-11-23T04:28:24Z JFM:YRS

Penetapan Kadar Na-Siklamat Pada Minuman Serbuk Instan Dan Minuman Kemasan Kaleng Yang Diperdagangkan Di Delitua Dengan Metode Alkalimetri Parhan, Parhan Na-Siklamat Alkalimetri Minuman Kemasan Minuman Serbuk Instan Packaging beverages or soft drinks are non-alcoholic beverages, processed or powdered liquors containing foodstuffs or other additives both natural and synthetic packaged in ready-to-eat packaging. Instant powder drink is one of the fast food beverage products that contain many artificial sweeteners. The most commonly used artificial sweetener is Na-cyclamate. The use of Na-Cyclamate in large doses will cause health problems. The purpose of this research is to know and compare the content of Na-Cyclamate in instant powder drink with beverage of canned packaging traded in Delitua with provisions SNI 01-6993-2004 that is 1000 mg / kg BB. Samples were collected from drink merchants in Delitua who sold instant powder beverages according to qualitative qualitative analysis criteria that aimed to see the Na-Cyclamate content in the sample by using the sedimentation test with BaCl2. Positive samples containing Na-Cyclamate were determined by Alkalimetry. The results showed that 6 samples of instant powdered beverage and canned container beverage contained Na-Cyclamate with content: A (402,2629 mg / kg), B (395.9280 mg / kg), C (405,4303 mg / kg ), D (272.3985 mg / kg), E (269.2311 mg / kg), and F (392.7606 mg / kg). From the data obtained, it is known that the samples A, B, C, D, E and F are safe for consumption, since the Na-Cyclamate content of the sample does not exceed the limits set by SNI 01-6993-2004 based on the food category of 1000 mg / kg. Na-Cyclamate content found in instant powder drink is higher than Na-Cyclamate levels contained in beverage cans packaging. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2018-10-15 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/88 10.35451/jfm.v1i1.88 JURNAL FARMASIMED (JFM); Vol. 1 No. 1 (2018): Jurnal FARMASIMED (JFM); 11-15 Jurnal FARMASIMED (JFM); Vol 1 No 1 (2018): Jurnal FARMASIMED (JFM); 11-15 2655-0814 10.35451/jfm.v1i1 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/88/28 10.35451/jfm.v1i1.88.g28 Copyright (c) 2018 Parhan Parhan

oai:ejournal.medistra.ac.id:article/90 2023-11-23T04:28:24Z JFM:YRS

UJI AKTIVITAS KANDUNGAN ANTIOKSIDAN PADA DAUN BANGUN-BANGUN (PLECTRANTHUS AMBOINICUS) SECARA SPEKTROFOTOMETRI ULTRAVIOLET-VISIBLE Kaban, Vera Estefania Yusmarlisa, Siti Daun Bangun-Bangun DPPH Antioksidan Analisis Spektrofotometri Ultraviolet-Visible. The population explosion that occurred in Indonesia has a profound effect on the quality of life of the community, such as the decline in the level of public health. Therefore leaf plants can be used as medicines that can be useful as antioxidants. Antioxidants are compounds that can inhibit free radicals due to the presence of reactive oxygen, so as to prevent various degenerative diseases. The compounds in the leaves of the buildings include flavonoids, alkaloids and polyphenols. To determine the presence of antioxidant content in wake-up leaves and to determine differences in antioxidant concentrations in wake-up leaves with vitamin C. Samples of leaves of the buildings used were obtained from the Pematang Siantar area, North Sumatra. Sample preparation was carried out by making leaf extracts. The activity test of antioxidant content in the wake-up leaf extract using ultraviolet-visible spectrophotometry. The results showed that there was a decrease in the value of DPPH absorbance given by the wake-up leaf extract test sample with vitamin C. A decrease in the absorbance value indicates a greater DPPH damping activity. The highest DPPH damping activity by leaf extracts of buildings with IC50 values of 20,2842 ppm can be categorized as having very strong DPPH damping activity. There is an antioxidant content with the IC50 category which is very strong in the leaves of the wake-up plant (Plectranthus amboinicus) and the higher the concentration of a test sample of wake-up leaf extract (Plectranthus amboinicus) and BPFI of vitamin C, the absorbance value decreases, The percentage of damping is higher and IC50 is lower, the antioxidant activity is higher. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2018-10-15 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/90 10.35451/jfm.v1i1.90 JURNAL FARMASIMED (JFM); Vol. 1 No. 1 (2018): Jurnal FARMASIMED (JFM); 16-20 Jurnal FARMASIMED (JFM); Vol 1 No 1 (2018): Jurnal FARMASIMED (JFM); 16-20 2655-0814 10.35451/jfm.v1i1 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/90/29 10.35451/jfm.v1i1.90.g29 Copyright (c) 2018 Vera Estefania Kaban, Siti Yusmarlisa

oai:ejournal.medistra.ac.id:article/91 2023-11-23T04:28:24Z JFM:YRS

SEDIAAN SALEP EKSTRAK DAUN KELOR (MORINGA OLEIFERA LAM) SEBAGAI PENYEMBUHAN LUKA BAKAR TOPIKAL PADA KELINCI (ORYCTOLAGUS CUNICULUS) Wahyudi, Wahyudi Agustina, Hanna ekstrak daun kelor luka bakar salep Burns is a form of tissue damage caused by contact with a heat source such as fire, hot water, chemicals, electricity and radiation. Burns occur on the skin, mucous membranes, respiratory tract and gastrointestinal tract. Actions that can be performed on burns is to provide local treatment with the aim to get relief as quickly as possible. One of the traditional medicines used empirically society as burn treatment is by softening Moringa leaves Moringa leaves and placed on the affected part of the wound. This tudy aim to determine the effect of healing of burns using Moringa leaf extract ointment and to determine the concentration of Moringa leaf extract in the ointment preparation is most effective in the healing of burns. Experimental method. Result of this study show phytochemical screening results indicate the presence of alkaloids, flavonoids, saponins, tannins. observations of Moringa leaf extract ointment preparation during storage of 7 days showed that the formula has a good appearance, homogeneous, smell and color. Diameter burns decline, a group of rabbits treated with the ointment extract of the leaves of Moringa 6% that is 0.9 cm, a group of rabbits given ointment extract of the leaves of Moringa 8% ie 0.91 cm, a group of rabbits given ointment extract of Moringa leaves 10% that is 0.95 cm, Bioplacenton® namely the group given 0.89 cm, while the group of rabbits given distilled water of 0.77 cm. Conclusion of this study show that extracts leaves of Moringa had an effect in the healing of burns. Ointments Moringa leaf extract 10% of the most effective in the healing of burns and has a greater potential than the Bioplacenton®. Burn healing effect on the concentration of 8% and 6% more effective than the negative comparison. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2018-10-15 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/91 10.35451/jfm.v1i1.91 JURNAL FARMASIMED (JFM); Vol. 1 No. 1 (2018): Jurnal FARMASIMED (JFM); 21-24 Jurnal FARMASIMED (JFM); Vol 1 No 1 (2018): Jurnal FARMASIMED (JFM); 21-24 2655-0814 10.35451/jfm.v1i1 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/91/30 10.35451/jfm.v1i1.91.g30 Copyright (c) 2018 Wahyudi Wahyudi, Hanna Agustina

oai:ejournal.medistra.ac.id:article/144 2023-11-23T04:27:59Z JFM:YRS

Uji Mutu Ekstrak Daun Sirsak (Annona muricata Linn.) Yang Di Ekstraksi Secara Maserasi Dengan Pelarut Etanol 70% surbakti, Christica ilsannas Nadiya, Nadiya Nadiya Soursop leaf, quality, extract, characterization, and phytochemical screening. Background : Gastric ulcer is wound to the mucosal layer (epithelial layer) of the stomach and mucosal irritation of 5 mm or more in diameter with depth down to submucosa. The basic pathogenesis of gastric ulcers in when there is an imbalance of aggressive factor enhancement. Non-steroidal antiinflammantory drug can cause stomach ulcers in two ways, either directly or topical irritation of the epithelial tissue and inhibit the endogeneous system of gastrointestinal mucosa of prostaglandins. In this case inhibition of prostaglandin systhesis is the dominant factor of peptic ulcers by NSAIDs. Objectives : The purpose of this study was to determine the effct of NSAID drug administration on the formation of peptic ulcers and to know the difference in the rate of formation of peptic ulcers from each class. Method : Sampel method mice performed surgery on the stomach is done in Pharmacology Laboratory of Pharmacy Institute Deli Husada Deli Tua. Results : The results of this study indicate that faster drugs cause gastric ulcers with a degree of redness are Aspirin 4.03 mm, 2.01 mm mefenamat and 1.02 mm Diclofenac Sodium while Ibuprofen mwdication does not cause peptic ulcers. Conclusion : The results of this study it can be concluded that Aspirin administration with doses of 21 mg/kg faster causes gastric ulcers from other NSAID groups such as Mefenamat with a dose of 21 mg/kg BW, Diclofenac sodium at a dose of 2 mg/kg  while administration, Ibuprofen for ten days does not couse ulcers in the stomach of experimetal animals. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2019-04-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/144 10.35451/jfm.v1i2.144 JURNAL FARMASIMED (JFM); Vol. 1 No. 2 (2019): Jurnal Farmasimed (JFM); 18-23 Jurnal FARMASIMED (JFM); Vol 1 No 2 (2019): Jurnal Farmasimed (JFM); 18-23 2655-0814 10.35451/jfm.v1i2 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/144/111 10.35451/jfm.v1i2.144.g111 Copyright (c) 2019 Christica ilsannas surbakti

oai:ejournal.medistra.ac.id:article/145 2023-11-23T04:27:59Z JFM:YRS

Formulasi Pembuatan Sediaan Eyeshadow dari Ekstrak Bunga Kecombrang (Etlingera elatior Jack) Barus, Bunga Rimta Kaban, Vera Estefania bunga kecombrang, pembuatan eyeshadow. One type of cosmetic or decorative cosmetic preparation is eyeshadow which contains a color pigment applied to the eyelid. The purpose of this study was to find out that kecombrang flower extract can be used as eyelid coloring. From the study to make eyeshadow preparations using dyes extracted from kecombrang flowers, to determine the stability of the eyeshadow by using kecombrang flower extract in storage at room temperature, and to find out whether eyeshadow preparations using extracts from kecombrang flowers cause irritation when used. Eyeshadow preparations from kecombrang flower extract (Etlingera elatior Jack) were made in various concentrations of 15%, 17.5%, 20%, 22.5%, 25% and blank preparations (without using kecombrang flower extract). Physical quality inspection of the preparation includes: color dispersion test (homogeneity), cracking test, and stock stability test. And for other tests carried out polishing tests (homogeneity) and irritation tests. Eyeshadow from kecombrang flower extract also does not cause irritation and is stable in room temperature storage for 30 days. Preparation of kecombrang flower extract with several good concentrations was used as eyeshadow preparations, stable eyeshadow preparations in storage at room temperature within 30 days, and the formulation of eyeshadow preparations using kecombrang flower extract as eyelid coloring did not cause irritation. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2019-04-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/145 10.35451/jfm.v1i2.145 JURNAL FARMASIMED (JFM); Vol. 1 No. 2 (2019): Jurnal Farmasimed (JFM); 1-4 Jurnal FARMASIMED (JFM); Vol 1 No 2 (2019): Jurnal Farmasimed (JFM); 1-4 2655-0814 10.35451/jfm.v1i2 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/145/102 10.35451/jfm.v1i2.145.g102 Copyright (c) 2019 Bunga Rimta Barus

oai:ejournal.medistra.ac.id:article/147 2023-11-23T04:27:59Z JFM:YRS

Pengaruh Kecepatan Pembentukan Tukak Lambung Terhadap Pemberian Berbagai Golongan NSAID Pada Tikus Jantan Parhan, Parhan Gulo, Aliman Yafarugi Gastric Stomach, NSAID, Aspirin, Mefenamat Acid, Diclofenac Sodium, Ibuprofen. Background : Gastric ulcer is wound to the mucosal layer (epithelial layer) of the stomach and mucosal irritation of 5 mm or more in diameter with depth down to submucosa. The basic pathogenesis of gastric ulcers in when there is an imbalance of aggressive factor enhancement. Non-steroidal antiinflammantory drug can cause stomach ulcers in two ways, either directly or topical irritation of the epithelial tissue and inhibit the endogeneous system of gastrointestinal mucosa of prostaglandins. In this case inhibition of prostaglandin systhesis is the dominant factor of peptic ulcers by NSAIDs.   Objectives : The purpose of this study was to determine the effct of NSAID drug administration on the formation of peptic ulcers and to know the difference in the rate of formation of peptic ulcers from each class.   Method : Sampel method mice performed surgery on the stomach is done in Pharmacology Laboratory of Pharmacy Institute Deli Husada Deli Tua.   Results : The results of this study indicate that faster drugs cause gastric ulcers with a degree of redness are Aspirin 4.03 mm, 2.01 mm mefenamat and 1.02 mm Diclofenac Sodium while Ibuprofen mwdication does not cause peptic ulcers.   Conclusion : The results of this study it can be concluded that Aspirin administration with doses of 21 mg/kg faster causes gastric ulcers from other NSAID groups such as Mefenamat with a dose of 21 mg/kg BW, Diclofenac sodium at a dose of 2 mg/kg  while administration, Ibuprofen for ten days does not couse ulcers in the stomach of experimetal animals. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2019-04-09 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/147 10.35451/jfm.v1i2.147 JURNAL FARMASIMED (JFM); Vol. 1 No. 2 (2019): Jurnal Farmasimed (JFM); 8-17 Jurnal FARMASIMED (JFM); Vol 1 No 2 (2019): Jurnal Farmasimed (JFM); 8-17 2655-0814 10.35451/jfm.v1i2 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/147/109 10.35451/jfm.v1i2.147.g109 Copyright (c) 2019 Parhan Parhan, Aliman Yafarugi Gulo

oai:ejournal.medistra.ac.id:article/148 2023-11-23T04:27:59Z JFM:YRS

Efektifitas Lumatan Daun Jambu Biji (Psidium guajava linn) Terhadap Penyembuhan Luka Bakar (Vulnus combustion) Pada Kelinci Wahyudi, Wahyudi Wahyudi Perbina, Dian Ika Lumatan daun jambu biji (Psidium guajava linn), Bioplacenton, Luka Bakar, Kelinci. Guava (Guava guajava linn) or guava contains high pectin so it can lower cholesterol, contain tannins that serves to improve the digestive system. Chemical compounds contained in the fruit guava echoes its shape is quersetin i.e. the type of flavonoid compounds a flavonol, flavones, and flavol, which helps them were to treat the fragility of capillaries in the human. The purpose of this research is to know the effectiveness of guava leaf lumatan (Guava guajava linn) in burn healing in rabbits. The methods used in this study was an experimental method using a control group, the Group and the comparison group test (perlakuaan). The results showed that of the negative control group provides the longest healing impact i.e. on the 13th, the positive control healing burns on day 8, and control using lumatan guava leaf healing burns on day 9 control group comparison, bioplacenton indicates days of healing Burns most rapidly healed.   Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2019-04-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/148 10.35451/jfm.v1i2.148 JURNAL FARMASIMED (JFM); Vol. 1 No. 2 (2019): Jurnal Farmasimed (JFM); 5-7 Jurnal FARMASIMED (JFM); Vol 1 No 2 (2019): Jurnal Farmasimed (JFM); 5-7 2655-0814 10.35451/jfm.v1i2 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/148/103 10.35451/jfm.v1i2.148.g103 Copyright (c) 2019 Wahyudi Wahyudi

oai:ejournal.medistra.ac.id:article/173 2023-11-23T04:27:59Z JFM:YRS

Perbedaan Teknik Penanaman Terhadap Hasil Jumlah Koloni Bakteri Escherichia Coli Pada Suhu Inkubasi 36C: Perbedaan Teknik Penanaman Terhadap Hasil Jumlah Koloni Bakteri Escherichia Coli Pada Suhu Inkubasi 36C RIZKY, VINCENTIA ADE E. coli, incubation temperature of 36ºC, plating technique Escherichia coli bacteria are gram-negative bacteria in form of single or paired cells it is included Enterobacteriaceae family and intestinal normal flora. Laboratory tests conducted for the calculation of the number of germs can be done using cultivation techniques using a loop and micropipet. The aim of this research is to know the difference of number of bacteria bacteria on calibrated loop and micropipet to colony of Escherichia coli bacteria.  This research is an analytical observation study with cross sectional design. The hypothesis was tested using independent t test with 95% confidence level. The results showed the average number colonies of Escherichia coli bacteria growing on PCA media using calibrated loop technique was 138,25 CFU/mL where as the average number of colonies of Escherichia coli bacteria grown on PCA media using micropipet technique was 104,56 CFU/mL, and significant value of p = 0,001. Furthemore, the result of data analysis showed that there were no any differences in the number of colonies of Escherichia coli bacteria in planting using calibrated loop technique and micropipet  at incubation temperature of 36ºC. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2019-10-02 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/173 10.35451/jfm.v1i2.173 JURNAL FARMASIMED (JFM); Vol. 1 No. 2 (2019): Jurnal Farmasimed (JFM); 24-26 Jurnal FARMASIMED (JFM); Vol 1 No 2 (2019): Jurnal Farmasimed (JFM); 24-26 2655-0814 10.35451/jfm.v1i2 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/173/113 Copyright (c) 2019 VINCENTIA ADE RIZKY

oai:ejournal.medistra.ac.id:article/191 2023-11-23T04:26:03Z JFM:YRS

STUDI PRELIMINARI TENTANG PENGARUH D-GALAKTOSA DALAM MENGINDUKSI STRES OKSIDATIF PADA MENCIT JANTAN GALUR OUTBRED FK USU Bintang, Siti Sarah Bintang Sarah Siregar, Yahwardiah Ichwan, Muhammad Oxidative oxidative stress, MDA, D-galaktosa Abstract   Oxidative stress occurs due to imbalance of free radicals over antioxidant level in the body. This condition causes lipid peroxidation and DNA damage. D-Galaktosa is   The mechanism of oxidative stress induced by d-galactose occurs in the subcellular, especially in the brain's mitochondria. Increasing the concentration of d-galaktosa is oxidized by galaktosa oxidase to form hydrogen peroxide (H202) which causes a decrease in superoxide dismutase (SOD). H202 reacts with reduced iron and forms hydroxide ions (OH-). Objective: The aim of this study was to determine the effect of d-galaktosa induction on oxidative stress levels (MDA) in male mice. Methods: Methods of samples of mice given d-galaktosa and blood collection from the heart were carried out at the Pharmacology Laboratory of the Faculty of Medicine, University of North Sumatra. Results: The results showed that administration of d-galaktosa, through intraperitonial injection every day for 6 weeks, had an effect on the levels of oxidative stress in male mice. Conclusion: The results of this study indicate that administration of d-galaktosa, through intraperitonial injection every day for 6 weeks, has an effect on levels of oxidative stress in male mice.   Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2019-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/191 10.35451/jfm.v2i1.191 JURNAL FARMASIMED (JFM); Vol. 2 No. 1 (2019): Jurnal Farmasimed (JFM); 1-5 Jurnal FARMASIMED (JFM); Vol 2 No 1 (2019): Jurnal Farmasimed (JFM); 1-5 2655-0814 10.35451/jfm.v2i1 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/191/164 Copyright (c) 2019 Siti Sarah Bintang Sarah Bintang

oai:ejournal.medistra.ac.id:article/194 2023-11-23T04:26:03Z JFM:YRS

EFEKTIFITAS PENGGUNAAN PEWARNA ALTERNATIF PREPARAT PERMANEN TELUR NEMATODA USUS MENGGUNAKAN PEWARNA RHODAMIN B Siregar, Saadah Krisdianilo, Visensius Rizky, Vincentia Ade Intestinal Nematode Eggs ,Hematoxylin - Eosin , Rhodamine B Staining is one of support microscopic examination in the identification of worm eggs. Staining techniques are needed to clarify the various elements and the description of the microscopic worm eggs and distinguish it from the surrounding dirt. Hematoxylin and Eosin staining  method that is widely used in the staining of histological tissue. Dyes commonly used in the examination of intestinal nematode eggs on is dye eosin. To added reference dye Rhodamine B dye used as an alternative to dye eosin. The method used is experiment by conducting concentration ratio of  Rhodamine B 1%, 1.5%, 2% and 2.5% to 2% eosin control. The results based on Kruskal-Wallis Test showed the normality test is 0.357, p-value sig (0.357) > 0.05, so that the data group to be tested otherwise normal. Then performed statistical tests Kruskal WallisTtest to determine the accuracy of the file thus obtained p-value (0.407) > 0.05, meaning there is no significant difference in the concentration of the dye Rhodamine B of the entire treatment. Morphology of worm eggs clearly visible from the outside layer to the inside layer, the visual field Rhodamine B dye is clearly visible, color contrast eggs are also clearly visible. From the research conducted, it can be concluded that the dye Rhodamine B dye can be used as an alternative to dye eosin. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2019-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/194 10.35451/jfm.v2i1.194 JURNAL FARMASIMED (JFM); Vol. 2 No. 1 (2019): Jurnal Farmasimed (JFM); 31-39 Jurnal FARMASIMED (JFM); Vol 2 No 1 (2019): Jurnal Farmasimed (JFM); 31-39 2655-0814 10.35451/jfm.v2i1 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/194/163 Copyright (c) 2019 Saadah Siregar

oai:ejournal.medistra.ac.id:article/285 2023-11-23T04:26:03Z JFM:YRS

IDENTIFIKASI KADAR VITAMIN C PADA DAGING DAN KULIT BUAH NAGA MERAH (HYLOCEREUS POLYRHIZUS) DENGAN METODE SPEKTROFOTOMETRI UV-VISIBLE Syarifuddin, Aminah Nur Zantrie, Rezky Teresia Marbun, Romauli Anna Vitamin C, the fles and the dragon red, spectrophotometry UVVisible. Introduction: Vitamin C is one of the nutrition acted as a antioxidants and effective addres free radicals can be destructive cells or tissue. Fruits are a source of vitamins C, which is a dragon red. Part of the dragon red during this rarely used is the skin. The dragon fruit is very useful to health, but in fact only thought of as waste  farming has yet to be used as a good. This study aims to determine comparison levels of vitamin C on the flesh and the dragon red (Hylocereus polyrhizus) with a method spectrophotometry UV-Visible. Method: This type of research using the method of true experimental reseach stage includes preparation of samples, qualitative test,quantitative test, making the solution of the parent raw materials, determination of wavelength of vitamin C and manufacture of the calibration curve. The sample of this study is the flesh and the dragon red (Hylocereus polyrhizus). Results: Based on the results revealed that the fles and the dragon red (Hylocereus polyrhizus) contain vitamin C. Discussion: Levels of vitamin C on the flesh the dragon red of 0.05888 mg/mL and The levels of vitamin C on the skin the dragon red of 0.02533 mg/mL .  Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2019-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/285 10.35451/jfm.v2i1.285 JURNAL FARMASIMED (JFM); Vol. 2 No. 1 (2019): Jurnal Farmasimed (JFM); 40-46 Jurnal FARMASIMED (JFM); Vol 2 No 1 (2019): Jurnal Farmasimed (JFM); 40-46 2655-0814 10.35451/jfm.v2i1 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/285/168 Copyright (c) 2019 Aminah Nur Syarifuddin

oai:ejournal.medistra.ac.id:article/286 2023-11-23T04:26:03Z JFM:YRS

UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN PIRDOT (SAURAUIA VULCANI KORTH.) TERHADAP BAKTERI SALMONELLA THYPI Octora, Debi Dinha Teresia Marbun, Romauli Anna Koto, Rahmadona Keywords: Ethanol Extract Pirdot Leaves (Saurauia vulcani Korth), Salmonella thypi, Antibacteria, Indonesia is known for the many plants that are used as traditional medicine for disease prevention, including the leaves of the pirdot (Saurauia vulcani Korth) family Actinidiaceae. This study aims to determine the antibacterial activity of ethanol extract of pirdot leaves (Saurauia vulcani Korth). The results of the characterization of pirdot leaf simplicia powder were obtained 3.99% water content, water soluble extract 12.15%, ethanol soluble extract 8.89%, total ash content 9.97%, insoluble ash content in acids 3.17%. The results of phytochemical screening tests contained the chemical compounds of steroids / triterpenoids, flavonoids, glycosides, tannins and saponins. Ethanol extract of pirdot leaf has antibacterial activity against Salmonella typhi bacteria. The treatment consisted of 4 concentrations, pirdot leaf extract with 3 repetitions, each blank (DMSO), 50 mg / ml, 100 mg / ml, 150mg / ml, 200 mg / ml. After that, it was incubated for 24 hours at 37oC. Inhibition zone diameter observations were made using calipers. The results obtained showed that administration of pirdot leaf extract at concentrations of 50 mg / ml, 100 mg / ml, 150 mg / ml and 200 mg / ml can inhibit the growth of Salmonella typhi bacteria. The results of the antibacterial activity test of pirdot leaf ethanol extract against Salmonella typhi bacteria obtained the highest inhibitory concentration of 200 mg / ml with a diameter of 20.48 mm. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2019-11-07 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/286 10.35451/jfm.v2i1.286 JURNAL FARMASIMED (JFM); Vol. 2 No. 1 (2019): Jurnal Farmasimed (JFM); 40-44 Jurnal FARMASIMED (JFM); Vol 2 No 1 (2019): Jurnal Farmasimed (JFM); 40-44 2655-0814 10.35451/jfm.v2i1 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/286/169 Copyright (c) 2019 Debi Dinha Octora

oai:ejournal.medistra.ac.id:article/292 2023-11-23T04:26:03Z JFM:YRS

EFEKTIFITAS EKSTRAK ETANOL DAUN SAWI HIJAU (BRASSICA RAPA VAR. PARACHINENSIS) SEBAGAI PELEMBAB KULIT DENGAN SEDIAAN MASKER PEEL-OFF Cahya, Cucu Arum Dwi Syarifuddin, Aminah Syukur, Ahmad Syukur peel-off mask, green mustard leaf extract, skin moisturize. Green mustard plants can be formulater into peel-off masks to moisturize the skin, because based on previous research green mustard leaves cointain flavonoids as antioxidants which can moisturize the skin. The purpose of this study was to find out green mustard leaves can be formulated into peel-off mask preparations and to find out the preparation and to find out the preparation off peel off mask with etanol extract of green mustard leaves can moisturize the skin. This study uses an experimental method. Green mustard leaves are extracted by maceration. In this study, a skin analyzer was usee as a mesure of skin moisture level after using peel off mask from a variety of dosage formulations which were divided into 5 preparations, blank (without mask, 3%,4%,5%), postive control (using peel off masks on the market). The Anova test results show a sig value of 0,000 or p<0,005 so it is concluded that the variabel has a difference. The conclusion of this study proves that the ethanol extract of green mustard leaves can be used as a peel-off mask for skin moisturizer, where the higher the concentration of mustard leaf extract, the higher the moisture vlue of the skin. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2019-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/292 10.35451/jfm.v2i1.292 JURNAL FARMASIMED (JFM); Vol. 2 No. 1 (2019): Jurnal Farmasimed (JFM); 6-15 Jurnal FARMASIMED (JFM); Vol 2 No 1 (2019): Jurnal Farmasimed (JFM); 6-15 2655-0814 10.35451/jfm.v2i1 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/292/165 Copyright (c) 2019 Cucu Arum Dwi Cahya

oai:ejournal.medistra.ac.id:article/304 2023-11-23T04:26:03Z JFM:YRS

EFEKTIFITAS IMUNOSTIMULAN DARI EKSTRAK ETANOL DAUN SIRSAK (ANNONA MUCIRATA) PADA TIKUS JANTAN DENGAN METODE HYPERSENSITIVITAS TIPE LAMBAT Wulandari, Suci Hasibuan, Ahmad Syukur Cahya, Cucu Arum Dwi Ekstrak Etanol Daun Sirsak (Annona mucirata), Penurunan Volume Pembengkakan Kaki Tikus, Hipersensitivitas Tipe Lambat. Penelitian pada skripsi ini bertujuan untuk mengetahui efektifitas imunostimulan dari ekstrak etanol daun Sirsak (Annona mucirata), dengan empat varian dosis. Penelitian ini menggunakan hewan tikus putih jantan sebanyak 18 ekor dengan BB 200 gram yang dibagi menjadi 6 kelompok perlakuan. Tikus diinduksikan dengan bakteri Escherichia coli selama 7 hari berturut turut secara intra peritoneum, kemudian pada hari ke 7 beri tanda di kaki tikus yang sudah diukur (V0). Ekstrak etanol daun Sirsak (Annona mucirata),  dengan varian dosis 50mg/kgBB, 100mg/kgBB, 200mg/kgBB, 400mg/kgBB, suspense CMC Na 0,5%, dan suspensi STIMUNO 25 mg/kgBB sebagai kontrol positif siberikan secara oral pada hari ke 8, setelah 24 jam setelah pemberian kemudian kaki tikus diukur kembali volumenya (Vt).catat hasil, selanjutnya seluruh data masing-masing kelompok diolah menggunakan uji ANOVA. Hasil penelitian menunjukan bahwa ekstrak etanol daun benalu kopi terbukti efektifbagai imunostimulan. Hal ini dibuktikan dengan adanya penurunan volume pembengkakan kaki tikus yang diuji dengan metode hipersensitifitas tipe lambat. Dikatakan efektif  karena memiliki nilai mendekati control positif yaitu stimuno 25 mg dimulai dari dosis 200mgkg/bb sampai 400mgkg/BB. Dengan nilai rata-rata penurunan volume pembengkakan 1,4mm untuk dosis 400mgkg/BB dan 1,2mm untuk dosis 200mgkg/BB. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2019-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/304 10.35451/jfm.v2i1.304 JURNAL FARMASIMED (JFM); Vol. 2 No. 1 (2019): Jurnal Farmasimed (JFM); 21-30 Jurnal FARMASIMED (JFM); Vol 2 No 1 (2019): Jurnal Farmasimed (JFM); 21-30 2655-0814 10.35451/jfm.v2i1 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/304/167 Copyright (c) 2019 suci wulandari

oai:ejournal.medistra.ac.id:article/323 2023-11-23T04:26:03Z JFM:YRS

UJI SENYAWA FLAVONOID TOTAL DARI EKSTRAK ETANOL HERBA BINARA (ARTEMISIA ANNUA) MENGGUNAKAN HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC) TAHUN 2019 Purba, Novandi Sinurat, Jhon Patar Marbun, Romauli Anna Teresia Kata Kunci :Herba Binara (Artemisia Annua), flavonoid, KLT, High Performance Liquid Chromatography(HPLC). ABSTRAK Herba binara (Artemisia Annua) is one of the plants that contains flavonoids which are efficacious as antioxidants and anticancer. The purpose of this study was to determine the total flavonoid compounds contained in ethanol extract of binara herbs (Artemisia Annua). Compounds in ethanol extract of binara herbs were identified by phytochemical screening. The results showed that the ethanol extract of binara herbs contained alkaloids, flavonoids, saponins, and tannins. Extraction was carried out in two stages, namely maceration stage with 96% ethanol and fat removal stage by hydrolysis using distilled water solvent. The extract was partitioned with ethyl acetate and n-hexane solvents, then the partitions were examined by TLC using the mobile phase of chloroform and ethyl acetate (7: 3). Ribbon patches that have the same Rf and color prices as the initial detection are taken and searched. Then analyzed using High Performance Liquid Chromatography (HPLC). Based on the wavelength as well as the TLC test, a partial structure which was strongly suspected of total flavonoids was 0.93 g.   Kata Kunci :Herba Binara (Artemisia Annua), flavonoid, KLT, High Performance Liquid Chromatography(HPLC).     Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2019-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/323 10.35451/jfm.v2i1.323 JURNAL FARMASIMED (JFM); Vol. 2 No. 1 (2019): Jurnal Farmasimed (JFM); 16-20 Jurnal FARMASIMED (JFM); Vol 2 No 1 (2019): Jurnal Farmasimed (JFM); 16-20 2655-0814 10.35451/jfm.v2i1 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/323/166 Copyright (c) 2019 Novandi Purba

oai:ejournal.medistra.ac.id:article/357 2023-11-23T04:25:26Z JFM:YRS

SKRINING FITOKIMIA EKSTRAK ETANOL UMBI BAWANG MERAH (Allium cepa L.) Hasibuan, Ahmad Syukur Edrianto, Vicky Purba, Novandi umbi bawang merah skrining fitokimia etanol Bawang merah (Allium cepa L) diketahui banyak mengandung senyawa yang memiliki aktivitas farmakologi. Etanol merupakan pelarut yang bersifat universal yang mampu melarutkan senyawa polar dan non polar serta memiliki sifat netral, absorbsi baik, tidak beracun dan stabil sehingga dapat digunakan untuk ekstraksi umbi bawang merah. Skrining fitokimia dilakukan untuk mengetahui golongan senyawa yang terkandung dalam ekstrak umbi bawang merah. Penelitian ini menggunakan ekstraksi dengan metode maserasi selama 5 hari dan dilanjutkan dengan remaserasi selama 2 hari. Kemudian ekstrak yang didapat dilakukan skrining fitokimia. Hasil skrining fitokimia umbi bawang merah menggunakan pelarut etanol menunjukkan adanya kandungan senyawa flavonoid, tanin, saponin, alkaloid dan steroid/terpenoid. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2020-04-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/357 10.35451/jfm.v2i2.357 JURNAL FARMASIMED (JFM); Vol. 2 No. 2 (2020): Jurnal Farmasimed (JFM); 45-49 Jurnal FARMASIMED (JFM); Vol 2 No 2 (2020): Jurnal Farmasimed (JFM); 45-49 2655-0814 10.35451/jfm.v2i2 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/357/182 Copyright (c) 2020 Ahmad Syukur Hasibuan

oai:ejournal.medistra.ac.id:article/360 2023-11-23T04:25:26Z JFM:YRS

A EFEKTIVITAS FORMULASI SEDIAAN SABUN MANDI PADAT EKSTRAK ETANOL DAUN BELIMBING WULUH (Averrhoa Bilimbi) SEBAGAI PELEMBAB KULIT Situmorang, Novidawati Boru Monica Marpaung, Dorima Aminah, Aminah Marbun, Romauli Anna Teresia Ekstrak Daun Belimbing Wuluh; Sabun Mandi Padat; Pelembab Kulit Daun belimbing wuluh dapat diformulasikan menjadi sediaan sabun mandi padat karena berdasarkan penelitian sebelumnya daun belimbing wuluh  mengandung antioksidan tinggi diwakili dengan kandungan senyawa flavonoid dan saponin. Tujuan penelitian ini adalah untuk mengetahui daun belimbing wuluh dapat diformulasikan kedalam sediaan sabun mandi padat dan sediaan sabut mandi padat dari ekstrak etanol daun belimbing dapat melembabkan kulit. Penelitian ini menggunakan metode eksperimental dimana daun belimbing wuluh diekstraksi dengan metode maserasi. Pemeriksaan sediaan sabun mandi padat yang dilakukan penelitian ini adalah uji skrining fitokimia, uji iritasi dan uji kelembapan kulit dengan dibuat dengan 5 kelompok uji yaitu konsentrasi 2,5%, 3,5% dan 4,5%, control negative dan control positif ( sediaan X yang beredar dipasaran).  Hasil pemeriksaan menggunakan skin analyzer sediaan dengan konsentrasi 4,5% paling tinggi melembabkan kulit yaitu 52,56% dan tidak mengiritasi kulit namun terjadi perubahan fisik setelah beberapa hari sedangkan dengan konsentrasi 3,55 melembabkan kulit 45,53% hamper setara dengan kontrol positif yang beredar dipasaran. Kesimpulan ekstrak etanol daun belimbing wuluh dapat diformulasikan menjadi sediaan sabun mandi padat dan dapat digunakan untuk melembabkan kulit. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2020-04-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/360 10.35451/jfm.v2i2.360 JURNAL FARMASIMED (JFM); Vol. 2 No. 2 (2020): Jurnal Farmasimed (JFM); 50-55 Jurnal FARMASIMED (JFM); Vol 2 No 2 (2020): Jurnal Farmasimed (JFM); 50-55 2655-0814 10.35451/jfm.v2i2 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/360/183 Copyright (c) 2020 Novidawati Boru Situmorang

oai:ejournal.medistra.ac.id:article/363 2023-11-23T04:25:26Z JFM:YRS

PENETAPAN KADAR VITAMIN C PADA KULIT PISANG (Musa paradisiaca) DENGAN METODE SPEKTROFOTOMETRI UV-VISIBLE TAHUN 2018 Pratiwi, Asti Manurung, Ardita Febrianty sumitra, Jhoti Vitamin C Skin Banana spectrofotometry UV-Visible Background: Vitamin C is a vitamin that is water soluble qnd one vitamin that are needed by the body. To meet the intake of vitamin C needed source of vitamin a derived from fruits, one of which is banana. Part of the banana , which is still rarely used is its skin. Banana peel is very beneficial for health however the situation is only considered as waste that has not been utilized well. This study aims to determine the levels of vitamin C on the skin of the banana (Musa paradisiaca) by the method of spectrofotometry uv-visible wavelength 224,5 nm. Method: This research use experimental with purely research stage comprise sample preparation, qualitative test, making the solution of the parent raw, quantitative test, determination of wavelength of maximum vitamin and creation of calibration surve. Result: Based on the research that has been done obtained the result of the qualitative test to prove the presence of high content of vitamin C contained in banana peels, with the highest level obtained in the skin of the plantain by 0,0253 mg/ml and the levels of the lowest on a banana peel the wax by 0,0172 ng/ml. Discussion: Levels of vitamin C on the skin of the banana  barangan of 0, 0219 mg/ml, sample a banana skin banten by 0, 0173 mg/ml, sample a banana peel wax by 0, 0172 mg/ml and sample the skin of plantain by 0, 0253 mg/ml. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2020-04-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/363 10.35451/jfm.v2i2.363 JURNAL FARMASIMED (JFM); Vol. 2 No. 2 (2020): Jurnal Farmasimed (JFM); 56-62 Jurnal FARMASIMED (JFM); Vol 2 No 2 (2020): Jurnal Farmasimed (JFM); 56-62 2655-0814 10.35451/jfm.v2i2 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/363/184 Copyright (c) 2020 Asti pratiwi, Ardita Febrianty Manurung, Jhoti sumitra

oai:ejournal.medistra.ac.id:article/364 2023-11-23T04:25:26Z JFM:YRS

FORMULASI SEDIAAN MASKER WAJAH MENGGUNAKAN EKSTRAK ETANOL BUNGA KECOMBRANG (ETLINGERA ELATIOR) TERHADAP KELEMBABAN KULIT WAJAH Pranata, Chandra Boru Situmorang, Novidawati Marbun, Romauli Anna Teresia Torch Ginger Flower Extract Facial Mask Clay Facial Mask Facial Skin Moisture ABSTRACT     Skin is an essential and vital organ and a reflection of health. Natural antioxidants such as flavonoids, polyphenols and Sapponin are believed to increase moisture on the skin. This ability is the main reason for using Torch Ginger flower extract which is formulated into a form of facial mask in the form of clay facial mask. Objective: To formulate facial moisturizing mask preparations using the extract of Torch Ginger(Etlingera elatior). This study used the Torch Ginger Flower extract facial moisturizing mask formulation method with a concentration of 0 (Blank), 5% and 10%. Evaluation of mask preparations included homogeneity, stability of dosage at temperatures of 80C and 250C, Organoleptic test and pH of preparations. Measurements of skin moisture activity were measured using alar Skin Analyzer which was tested on the face surface 3cm wide. The results showed that the preparation was stable in terms of odor, color and was at a pH of 4.2-6.3 using observations of litmus discoloration. Effectiveness of facial skin moisture with 10% Torch Ginger extract concentration is more effective to produce results at a concentration of 5% and blank. Conclusion: Torch Ginger flower extract can be formulated into preparations of face masks with various concentrations and has the effect of moisturizing the skin and brightening the complexion. Keywords: Torch Ginger Flower Extract, Facial Mask, Clay Facial Mask, Facial Skin Moisture Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2020-04-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/364 10.35451/jfm.v2i2.364 JURNAL FARMASIMED (JFM); Vol. 2 No. 2 (2020): Jurnal Farmasimed (JFM); 63-68 Jurnal FARMASIMED (JFM); Vol 2 No 2 (2020): Jurnal Farmasimed (JFM); 63-68 2655-0814 10.35451/jfm.v2i2 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/364/185 Copyright (c) 2020 Chandra Pranata

oai:ejournal.medistra.ac.id:article/368 2023-11-23T04:25:26Z JFM:YRS

UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN KEMANGI (Ocimum basilicum L.) TERHADAP BAKTERI Streptococcus mutans Syarifuddin, Aminah Nur Purba, Rosa Aldora Boru Situmorang, Novidawati Marbun, Romauli Anna Teresia Basil leaf, Antibacterial, and Streptococcus mutans. Introduction: Basil leaf (Ocimum basilicum L.) is one of the most accessible natural plant in Asia such as Indonesia. Basil leaf vegetation contains a lot of flavonoid compounds and essential oils that have the effect as antibacterial because it can inhibit the growth of bacteria Streptococcus mutans cause dental caries. Streptococcus mutans is a round gram-positive bacteria that typically form pairs or chains during its growth. The purpose of this research is to know the antibacterial effectivity of ethanol extract of basil leaves (Ocimum basilicum L.) on the growth of Streptococcus mutans bacteria.This research was conducted with laboratory experimental research method. Basil lean ethanol extract was prepared by using maseration extraction method. Method: The method used in the inhibitory test using diffusion of the disc with 5 samples in each treatment group. The sample consisted of 5 treatment groups, ethanol  extract of basil leaves with concentration of 100%, 80%, 60%, 40% and 20%. Result: The result of this study showed that ethanol extract of basil leaves with 100% concentration had inhibitory power of 10,26 mm (strong category), 80% of 9,65 mm (medium category), 60% by 8,12 mm (medium category), 40% by 7,33 mm (medium category), and 20% by 6,90 mm (medium category). Conclusion: The conclusion of this research proves that basil leaf ethanol extract has antibacterial power agains Streptococcus mutans bacteria with effective concentration is 100% with strong category equal to 10,26 mm. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2020-04-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/368 10.35451/jfm.v2i2.368 JURNAL FARMASIMED (JFM); Vol. 2 No. 2 (2020): Jurnal Farmasimed (JFM); 69-76 Jurnal FARMASIMED (JFM); Vol 2 No 2 (2020): Jurnal Farmasimed (JFM); 69-76 2655-0814 10.35451/jfm.v2i2 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/368/186 Copyright (c) 2020 Aminah Nur Syarifuddin

oai:ejournal.medistra.ac.id:article/369 2023-11-23T04:25:26Z JFM:YRS

FORMULASI SEDIAAN SABUN MANDI PADAT EKSTRAK ETANOL BONGGOL NANAS (Ananas cosmosus L.) UNTUK KELEMBAPAN KULIT Octora, Debi Dinha Situmorang, Yuliana Marbun, Romauli Anna Teresia Bonggol Nanas; Sabun Mandi Padat; Pelembab Kulit Tanaman nanas dapat diformulasikan menjadi sediaan sabun mandi padat karna berdasarkan penelitian sebelumnya bonggol nanas menggandung antioksidan tinggi karena memiliki senyawa flavonoid dan saponin. Senyawa  yang mampu menangkal  radikal bebas adalah antioksidan. Penelitian ini menggunakan metode quasi eksperimental. Pengumpulan sampel, pembuatan simplisia, pembuatan ekstraksi secara maserasi menggunakan pelarut etanol dan pembuatan sediaan sabun padat dengan ekstrak etanol bonggol nanas masing-masing dengan konsentrasi 3%, 4% dan 5%. Kemudian dilakukan uji sabun meliputi: pengukuran pH, ketingian busa sabun, dan uji kemampuan sediaan untuk melembabkan kulit pada responden sebanyak 10 orang selama ± 1 jam dengan menggunakan alat skin analyzer. Ekstrak etanol bonggol nanas dapat diformulasikan menjadi sediaan sabun mandi padat dengan hasil uji pH menunjukan konsentrasi 5% lebih tinggi, hasil uji ketinggian busa menunjukan konsentrasi 5% lebih tinggi dan hasil pemeriksaan kelembaban kulit menunjukan konsentrasi 5% lebih lembab. Hasil penelitian menunjukan sediaan sabun mandi padat dari ekstrak etanol bonggol nanas (AnanasCosmosusL) untuk melembabkan kulit dengan variasi konsentrasi yang berbeda dapat diformulasikan menjadi sediaan sabun mandi padatdengan hasil uji pH menunjukan stabil pada kulit dan hasil pemeriksaan kelembaban kulit menunjukan konsentrasi 5% lebih lembab. Diharapkan untuk penelitian selanjutnya agar dapat membuat sediaan lain dari ekstrak etanol bonggol nanas (Ananas cosmosus L.) dalam bentuk sediaan lain seperti sabun cair, lotion, sabun transparan, krim dan sebagainya. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2020-04-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/369 10.35451/jfm.v2i2.369 JURNAL FARMASIMED (JFM); Vol. 2 No. 2 (2020): Jurnal Farmasimed (JFM); 77-84 Jurnal FARMASIMED (JFM); Vol 2 No 2 (2020): Jurnal Farmasimed (JFM); 77-84 2655-0814 10.35451/jfm.v2i2 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/369/187 Copyright (c) 2020 Debi Dinha Octora

oai:ejournal.medistra.ac.id:article/372 2023-11-23T04:25:26Z JFM:YRS

EFEKTIFITAS IMUNOSTIMULLAN DARI EKSTRAK ETANOL DAUN BENALU KOPI (Loranthus ferrugineus Roxb) PADA TIKUS JANTAN DENGAN METODE TITER ANTIBODI Purba, Novandi Sari, Lasma Novita Ginting, Radika Farmasi ethanol extract of coffee parasite leaves (Loranthus ferrugineus Roxb), increases antibodies through the hemagglutination process. The research in this paper aims to determine the effectiveness of immunostimulants from ethanol extract of coffee parasite leaves (Loranthus ferrugineus Roxb) with four variants of doses of 50mg / kgBB, 100mg / kgBB, 200mg / kgBB, 400mg / kgBB. This study used 18 male white rats with 200 gram BB which were divided into 6 treatment groups. Rats were injected with 0.1ml SDMS 1% for 7 consecutive days intraperitoneal, then on the 7th day each blood sample was taken through veins in the tail, CMC Na 0.5% suspension, and Levamisole suspension 50mg / kgBB as a positive control was administered orally on the 8th day. Then blood samples were collected in a micro tube and then 1900rpm was centrifuged at a temperature of 4oC for 10 minutes. The results of the study of ethanol extract of coffee parasite leaves proved effective as immunostimulants because they have a value close to positive control, starting from a dose of 200mg / kgBB to 400mg / kgBB. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2020-04-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/372 10.35451/jfm.v2i2.372 JURNAL FARMASIMED (JFM); Vol. 2 No. 2 (2020): Jurnal Farmasimed (JFM); 91-96 Jurnal FARMASIMED (JFM); Vol 2 No 2 (2020): Jurnal Farmasimed (JFM); 91-96 2655-0814 10.35451/jfm.v2i2 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/372/189 Copyright (c) 2020 Novandi Purba, Lasma Novita Sari, Radika Ginting

oai:ejournal.medistra.ac.id:article/373 2023-11-23T04:25:26Z JFM:YRS

UJI EFEKTIVITAS ANTIBAKTERI SEDIAAN SALEP DARI EKSTRAK DAUN KERSEN (Muntingia calabura L.) TERHADAP BAKTERI Staphylococcus aureus Turnip, Nur Ulina M. Br. ., Nurdianti Dwicahya, Cucu Arum Salep ekstrak daun kersen (Muntingia calabura L.) Staphylococcus aureus Salah satu penyebab infeksi adalah bakteri, seperti Staphylococcus aureus. Daun kersen telah banyak digunakan untuk mengobati penyakit yang disebabkan oleh bakteri. Daun kersen telah diteliti memiliki aktivitas antibakteri terhadap  bakteri Staphylococcus aureus. Tujuan penelitian ini: membuat formulasi sediaan salep ekstrak daun kersen,  dan melihat apakah sediaan salep  memiliki aktivitas antibakteri terhadap bakteri  Staphylococcus aureus. Metode penelitian yang dilakukan pada penelitian ini bersifat True experimental, meliputi tahapan: pembuatan ekstrak daun kersen dengan metode maserasi menggunakan pelarut etanol 96%, formulasi salep dibuat dengan dasar salep: vaselin, adeps lanae, dan propilen glikol. Dibuat dalam tiga konsentrasi yaitu: F I dengan 100 mg, F II dengan 200 mg, dan F III dengan 300 mg. Selanjutnya dilakukan evaluasi sediaan berupa evaluasi stabilitas fisik dan homogenitas, dan uji aktivitas dengan bakteri Staphylococcus aureus dengan  menggunakan metode difusi agar menggunakan kertas cakram. Hasil menunjukkan bahwa salep memiliki kestabilan fisik dan homogenitas yang baik selama 10 hari penyimpanan pada suhu kamar. Uji aktivitas antibakteri  sediaan salep menunjukkan bahwa diameter hambat F I memiliki rata-rata 14,35 mm, F II memiliki rata-rata 16,50 mm dan F III memiliki rata-rata 19,29 mm. Berdasarkan hasil yang diperoleh maka dapat disimpulkan bahwa sediaan salep ekstrak daun kersen memiliki daya hambat terhadap bakteri Staphylococcus aureus. Pada peneliti selanjutnya diharapkan agar memperhatikan daerah tumbuh daun kersen yang akan digunakan sebagai sapel penelitian dan melakukan perbandingan pengujian aktivitas antibakteri antara daun kersen dengan daun yang lainnya terhadap bakteri Staphylococcus aureus. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2020-04-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/373 10.35451/jfm.v2i2.373 JURNAL FARMASIMED (JFM); Vol. 2 No. 2 (2020): Jurnal Farmasimed (JFM); 85-90 Jurnal FARMASIMED (JFM); Vol 2 No 2 (2020): Jurnal Farmasimed (JFM); 85-90 2655-0814 10.35451/jfm.v2i2 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/373/188 Copyright (c) 2020 Nur Ulina M. Br. Turnip, Nurdianti ., Cucu Arum Dwicahya

oai:ejournal.medistra.ac.id:article/374 2023-11-23T04:25:26Z JFM:YRS

EFEKTIVITAS ANALGETIK EKSTRAK ETANOL AKAR ALANG-ALANG (Imperata cylindrica (L) Beauv ) PADA MENCIT PUTIH JANTAN Kartika, Dewi Gultom, Veronika Yuliyani Sitompul, Andelila Suprianti analgesics Imperata cylindrica L. Beauv plantar test infra red Pain is an unpleasant sensory and emotional experience due to tissue damage, either actual or potential or described in the form of damage. Provision of therapeutic doses of analgesics relieve pain or suppress. Plants Imperata cylindrica L. Beauv empirically used as traditional medicine. The purpose of this study to know the analgetic effect of root ethanol extract of alang-alangImperata cylindrica L. Beauv. This study was done by infra red (IR) plantar test method with a wavelength of 96 nm. Twenty male mice were divided into 4 groups. Three groups were given ethanol extract of Imperata cylindrica L. Beauv branches at a doses of 15 mg/kg bb, 30 mg/kg bb 60 mg/kg bb and one group was given 0,5% CMC Na (control) orally. After that, the time (second) hold infra red induction of pain every 10 minutes to 60 minutes. The data obtained were processed using one-way analysis of variance (ANOVA) and followed test the level of 95%. The results of phytochemical screening  Imperata cylindrica L. Beauv is alkaloid, flavonoid, and steroid/triterpenoid. Ethanol extract Imperata cylindrica L. Beauv dose of 15 mg/kg bb average  induction able to withstand pain of 12,86; 14,34; 15,44; 19,2; 17,52; 15,42 second, the dose of 30 mg/kg bb 13,6; 17,08; 19,82; 18,44; 16,9; 16,48 second, and a dose of 60 mg/kg bb 16,96; 18,9; 18,94; 22,14; 18,0; 17,26 second. Pain is an unpleasant sensory and emotional experience due to tissue damage, either actual or potential or described in the form of damage. Provision of therapeutic doses of analgesics relieve pain or suppress. Plants Imperata cylindrica L. Beauv empirically used as traditional medicine. The purpose of this study to know the analgetic effect of root ethanol extract of alang-alangImperata cylindrica L. Beauv. This study was done by infra red (IR) plantar test method with a wavelength of 96 nm. Twenty male mice were divided into 4 groups. Three groups were given ethanol extract of Imperata cylindrica L. Beauv branches at a doses of 15 mg/kg bb, 30 mg/kg bb 60 mg/kg bb and one group was given 0,5% CMC Na (control) orally. After that, the time (second) hold infra red induction of pain every 10 minutes to 60 minutes. The data obtained were processed using one-way analysis of variance (ANOVA) and followed test the level of 95%. The results of phytochemical screening  Imperata cylindrica L. Beauv is alkaloid, flavonoid, and steroid/triterpenoid. Ethanol extract Imperata cylindrica L. Beauv dose of 15 mg/kg bb average  induction able to withstand pain of 12,86; 14,34; 15,44; 19,2; 17,52; 15,42 second, the dose of 30 mg/kg bb 13,6; 17,08; 19,82; 18,44; 16,9; 16,48 second, and a dose of 60 mg/kg bb 16,96; 18,9; 18,94; 22,14; 18,0; 17,26 second. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2020-04-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/374 10.35451/jfm.v2i2.374 JURNAL FARMASIMED (JFM); Vol. 2 No. 2 (2020): Jurnal Farmasimed (JFM); 97-101 Jurnal FARMASIMED (JFM); Vol 2 No 2 (2020): Jurnal Farmasimed (JFM); 97-101 2655-0814 10.35451/jfm.v2i2 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/374/190 Copyright (c) 2020 Dewi Kartika, Veronika Yuliyani Gultom, Andelila Suprianti Sitompul

oai:ejournal.medistra.ac.id:article/377 2023-11-23T04:23:37Z JFM:YRS

UJI EFEK ANTIINFLAMASI KOMBINASI EKSTRAK ETANOL DAUN GYMNANTHEMUM AMYGDALINUM DEL. DAN ELAEIS GUINEENSIS JACQ. Wahyudi, Wahyudi Masnawati, Masnawati ., Ismayuni Rahmi, Sofia Berkat Waruwu, Syukur Gymnanthemum amygdalinum, Elaeis guineensis, Inflammation Inflammation is a response from the body to injury or infection, flavonoids contained in African leaves (Gymnanthemum Amygdalinum Del.) And palm oil leaves (Elaeis Guineensis Jacq.) have anti-inflammatory effects. This study aims to examine the anti-inflammatory effects of a combination of ethanol extracts of Gymnanthemum Amygdalinum Del. And Elaeis Guineensis Jacq. on white rat foot edema which is induced by carrageenan 1% subplantar, and effective dosage as anti-inflammatory. The extract was made by maceration method using 96% ethanol solvent. The antiinflammatory effect test was divided into 5 treatment groups. The first group (negative control) was given 0.5% CMC Na suspension, the group (positive control) was given diclofenac Na suspension 2.25 mg / kg bw, and the suspension group was a combination of African leaf extract (Gymnanthemum Amygdalinum Del.) And palm oil leaves ( Elaeis Guineensis Jacq.) Dose 200 + 62.5 mg / kg bw, 400 + 125 mg / kg bw, and 800 + 250 mg / kg bw. Inflammation volume measurements were measured using a pletismometer for 180 minutes at 30 minute intervals after 1% carrageenan was induced. The results showed that negative controls had significant differences with other treatment groups which did not show anti-inflammatory effects. In conclusion, the suspension of a combination of ethanol extract of African leaves and palm oil leaves has an effective anti-inflammatory effect at a dose of 800 + 250 mg / kg bw. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2020-10-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/377 10.35451/jfm.v3i1.377 JURNAL FARMASIMED (JFM); Vol. 3 No. 1 (2020): Jurnal Farmasimed (JFM); 1-5 Jurnal FARMASIMED (JFM); Vol 3 No 1 (2020): Jurnal Farmasimed (JFM); 1-5 2655-0814 10.35451/jfm.v3i1 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/377/266 Copyright (c) 2020 Wahyudi Wahyudi

oai:ejournal.medistra.ac.id:article/382 2023-11-23T04:25:26Z JFM:YRS

UJI AKTIVITAS EKSTRAK ETANOL DAUN KARAMUNTING (Rhodomyrtus tomentosa.) TERHADAP PERTUMBUHAN BAKTERI Salmonella thypi Wulandari, Suci Pranata, Chandra Sihombing, Yanna Rotua Nasution, Muhammad Hamim karamunting leaf extract (Rhodomyrtus tomentosa.), Salmonella thypi, inhibitory power. Salmonella thypiis a bacterium that causes typhoid fever. Typhoid fever is an infectious disease that is still a health problem, especially in Indonesia. There are several studies on the types of plants that can control bacterial growth. Indonesian plants are often used as medicine, one of which is the karamunting (Rhodomyrtus tomentosa.). Traditionally a number of parasitic species have been used to prevent and treat various diseases such as cough, anticancer, diuretic, anti-inflammatory, antibacterial, wound or infection karamunting (Rhodomyrtus tomentosa.) Has active compounds such as flavonoids, alkaloids, tannins , saponins, and glycosides which have antibacterial abilities. The purpose of this study is to determine the inhibition of extract of karamunting (Rhodomyrtus tomentosa.) at concentrations of 5%, 10%, and 15%. Test samples using Salmonella thypi. This research is an experimental study with a design (posttest). The research methods included the collection of plant material, determination of plant material, making simplicia, phytochemical screening, making ethanol extract from simplicia by maceration, testing chemical compound groups, and antibacterial testing with paper disk diffusion methods. Karamunting is extracted by maceration process, using 70% ethanol solvent. The results of this study indicate that the benalu coffee leaf extract (Rhodomyrtus tomentosa.) has inhibitory capacity as an antibacterial in Salmonella thypi with a mean inhibition of 16.87 mm at a concentration of 5%, 17.24 mm at a concentration of 10%, and 18.21 mm at a concentration of 15%. The greatest inhibition is produced at a concentration of 15%, because the higher the concentration of the extract, the higher the diameter of the inhibition produced, because the more active substances contained in the extract. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2020-04-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/382 10.35451/jfm.v2i2.382 JURNAL FARMASIMED (JFM); Vol. 2 No. 2 (2020): Jurnal Farmasimed (JFM); 102-108 Jurnal FARMASIMED (JFM); Vol 2 No 2 (2020): Jurnal Farmasimed (JFM); 102-108 2655-0814 10.35451/jfm.v2i2 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/382/191 Copyright (c) 2020 Suci Wulandari

oai:ejournal.medistra.ac.id:article/450 2023-11-23T04:23:37Z JFM:YRS

PERBANDINGAN FORMULASI EKSTRAK E PERBANDINGAN FORMULASI EKSTRAK ETANOL BUAH TERONG BELANDA SEBAGAI PEWARNA PADA BLUSH ON DALAM BENTUK SEDIAAN COMPACT Barus, Bunga Rimta Estevania Kaban, Vera Octavia Aitonang, Jessi Berkat Waruwu, Syukur Blush on, Compact powder, Tree Tomato fruit Blush on is a cosmetic preparation for coloring the cheeks with an artistic touch so that it can increase the attractive impression in makeup (Nurhayati, 2016). Many blush-on preparations come from chemicals, which can cause spotty, black spots and can trigger skin cancer. One alternative that can be used is by making a blush on natural ingredients, namely Tree Tomato. The purpose of this study was to find out the Ethanol Extract of the Tree Tomato Fruit was made as a blush on coloring in compact preparations.The sample used in this study was Tree Tomato, red and had a soft texture taken from the cultivation of Tree tomato in the village of Brastagi, Karo District, North Sumatra Province. Making extracts is done by maceration and the process of making blush. After that evaluation of blush on preparation is carried out. Evaluation test results of blush on ethanol extract of tree tomato fruit include. The results of homogeneity tests are declared homogeneous, pH test averages 6.4, irritation test results stated not to irritate, the test results of the three formulations can be concluded that the three most preferred form of blush on panelists are formulations with a concentration of 15%, because they have a comfortable level of application, clear colors and very soft.Ethanol extract of Tree Tomato fruit can be made as a dye in compact preparations. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2020-10-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/450 10.35451/jfm.v3i1.450 JURNAL FARMASIMED (JFM); Vol. 3 No. 1 (2020): Jurnal Farmasimed (JFM); 6-10 Jurnal FARMASIMED (JFM); Vol 3 No 1 (2020): Jurnal Farmasimed (JFM); 6-10 2655-0814 10.35451/jfm.v3i1 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/450/267 Copyright (c) 2020 Bunga Rimta Barus

oai:ejournal.medistra.ac.id:article/472 2023-11-23T04:23:37Z JFM:YRS

UJI EFEKTIVITAS ANTI BAKTERI EKSTRAK DAUN LEUNCA (SOLANUM NIGRUM) TERHADAP DAYA HAMBAT BAKTERI ESCHERICHIA COLI Fahdi, Firdaus Sari, Herviani Saulina Lubis, Lisbet Antibacterial, Escherichia coli, Leunca’s Leaf Antibacterial is a compound that can inhibit the growth of bacteria that can be used for the treatment of infections in humans. One of the bacteria that can cause interference with the system is the Escherichia coli bacteria, where the Escherichia coli bacteria is widely spread around us. The spread of the Escherichia coli bacteria can occur by direct contact (shaking hands, touching). Then passed on by mouth. Leunca leaves have chemical contents including alkaloids, flavonoids, saponins, tanins. The purpose of this study was to determine whether Leunca's leaf extract (Solanum nigrum) has antibacterial effects against the inhibitory power of Escherichia coli bacteria with a concentration of 50 mg/ml, 100 mg/ml, 150 mg/ml, 200 mg/ml, 250 mg/ml. The method of this study was the sample of Leunca leaf obtained from West Lumban Rau Village, Habinsaran Subdistrict, Toba Samosir Regency. Sample preparation was done by making thick extract with the maceration method. An anti-bacterial effectiveness test is done by the disk diffusion method. The results showed Leunca's leaf extract containing alkaloid compounds, flavonoids, saponins, tannins. As well as having antibacterial effectiveness against the inhibition of Escherichia coli bacteria. Average inhibition zone area concentration of 50 mg/ml = 6.1 mm, concentration of 100 mg/ml = 7.3, concentration of 150 mg/ml = 8.8 mm, concentration of 200 mg/ml = 10.8 mm, concentration of 250 mg/ml = 12.6 mm. Conclusion: Leunca (Solanum nigrum) Leaf Extract has antibacterial effects against the inhibitory power of Escherichia coli bacteria with a strong category. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2020-10-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/472 10.35451/jfm.v3i1.472 JURNAL FARMASIMED (JFM); Vol. 3 No. 1 (2020): Jurnal Farmasimed (JFM); 11-16 Jurnal FARMASIMED (JFM); Vol 3 No 1 (2020): Jurnal Farmasimed (JFM); 11-16 2655-0814 10.35451/jfm.v3i1 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/472/268 Copyright (c) 2020 Firdaus Fahdi

oai:ejournal.medistra.ac.id:article/473 2023-11-23T04:23:37Z JFM:YRS

EFEK EKSTRAK DAUN GAMBIR ( UNCARIA GAMBIR ROXB) TERHADAP TINGKAT STRESS OKSIDATIF DAN EKSPRESI SIRTUIN 3 PADA HIPOKAMPUS MENCIT BETINA MODEL PENUAAN YANG DIINDUKSI D-GALAKTOSA Sinaga, Inda MH Sari, Mutiara Indah Ichwan, Muhammad MH D-Galactose, Malondealdehid Sirtuin 3 Cathechin The aging process must be experienced by all living things, there will be a decrease in the tissue ability to maintain its function so that pathological conditions occur. Some things can cause aging, Free radical factors are external and internal factors that can trigger aging. Induce of d-galactose continuously one of the factors that can increase oxidative stress. This study was design to evaluate the effect of gambir leaf extract on oxidative stress and expression of the sirtuin 3 gene in the hippocampus of female mice induced intraperitoneally by d-galactose 150 mg/kgbb. Researchers conducted a post test only control group study with a sample of 24 female mice aged 10 - 12 weeks with the inclusion criteria an average body weight of 25-35 grams, obtained from the same breeding place, maintained at the same place and time and never as research material. Mice were divided into 4 groups with 6 mice each , group (C) female mice induced only d-galactose 150 mg / kg and in sonde aquabidest  0,1%/body weight, mice induced by d-galactose and sonde gambir leaf extract at a dose of 100 mg / kg bw group (C1), group (C2) 200 mg/kgbw, and 400 mg/kgbw group (C3). Blood samples were collected to determine the increase in oxidative stress levels of malondealdehyde (MDA) through spectrophotometry, and hippocampal tissue collected for PCR method so that the expression of the sirtuin 3 gene can be seen. Increased levels of MDA are associated with increased oxidative stress. This study reported the results of MDA levels were not significant ( p value <0.05). The results of the PCR reported an increase in expression 2 times higher than the control at a dose of gambier leaf extract 200 mg / kgbw Keywords:D-Galactose, Malondealdehid,Sirtuin 3,Cathechin. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2020-10-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/473 10.35451/jfm.v3i1.473 JURNAL FARMASIMED (JFM); Vol. 3 No. 1 (2020): Jurnal Farmasimed (JFM); 17-25 Jurnal FARMASIMED (JFM); Vol 3 No 1 (2020): Jurnal Farmasimed (JFM); 17-25 2655-0814 10.35451/jfm.v3i1 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/473/269 Copyright (c) 2020 Inda MH Sinaga, Mutiara Indah Sari, Muhammad MH Ichwan

oai:ejournal.medistra.ac.id:article/475 2023-11-23T04:23:37Z JFM:YRS

EFEK EKSTRAK DAUN GAMBIR ( UNCARIAGAMBIRROXB) TERHADAP TINGKAT STRESS OKSIDATIF DAN EKSPRESI BRAIN DERIVED NEUROTHROPIC FACTOR(BDNF) PADA HIPOKAMPUS MENCIT BETINA MODEL PENUAANYANG DIINDUKSI D-GALAKTOSA Sebayang, Julenda Irianti Sari, Mutiara Indah Ichwan, Muhammad Indah Cathechins Stress oksidatif BDNF D-Galactose Prevalence of premature aging that causes in decreased memory throughout the world of individuals aged 60 years and over is estimated at 5-7%. According to WHO this is caused by progressive dysfunction and neuronal cell death and is related to free radical formation. This study was design to evaluate the effect of gambir leaf extract ( uncariaGambirRocb ) on MDA and expression BDNF in the hippocampus of aging female mice that are induced in D-Galactose. In this study that method is used a post test only control group, the researcher design with 4 groups being treated ( group1 : inject D-Galactose 150 mg/kgbb/ip and sondeaquabidest 0,1%, group 2 : sondecathechins 100 mg and inject D-Galactose 150mg/kgbb, group 3 ; sondecathechins 200 mg and inject D-Galactose 150 mg/kgbb, group 4 : sondecathechine 400 mg and inject D-Galactose150 mg/kgbb) with the inclusion criteria : all female mice (MusMusculus L) were 10-12 weeks old and had not been studied. MDA is examined through blood serum with spektrofotometer. Isolation RNA with Kit Tiangen Kat DP419 and BDNF expression from the hippocampus by RT PCR Increased level of MDA showed increased stress oksidatif. This study the result of MDA levels were not significant ( p value <0.05 ). There was an increase in BDNF expression in the K2 group compared to the other group in the Control, but it was not significant. The dose of 200 mg/kgbb is determine as the most effective dose of gambier beverage to improve the memory of female mice. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2020-10-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/475 10.35451/jfm.v3i1.475 JURNAL FARMASIMED (JFM); Vol. 3 No. 1 (2020): Jurnal Farmasimed (JFM); 26-31 Jurnal FARMASIMED (JFM); Vol 3 No 1 (2020): Jurnal Farmasimed (JFM); 26-31 2655-0814 10.35451/jfm.v3i1 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/475/270 Copyright (c) 2020 julenda Irianti Sebayang, Mutiara Indah Sari, Muhammad Indah Ichwan

oai:ejournal.medistra.ac.id:article/499 2023-11-23T04:23:37Z JFM:YRS

UJI AKTIVITAS EKSTRAK ETANOL DAUN LABU SIAM (SECHIUM EDULE (JACQ.) SWARTZ) TERHADAP AKTIVITAS ANTIBAKTERI STAPHYLOCOCCUS AUREUS Cahya, Cucu Arum Dwi Priasa, Ayunda M. Br. Turnip, Nur Ulina Daun labu siam aktivitas antibakteri Staphylococcus aureus Labu siam merupakan tumbuhan jenis labu-labuan yang dapat dimakan buah dan pucuk mudanya. Tumbuhan labu siam mengandung senyawa metabolit sekunder antara flavonoid, alkaloid, saponin. Tujuan penelitian ini adalah untuk mengetahui pengaruh ekstrak daun labu siam (Sechium edele (Jacq.) Swartz) terhadap pertumbuhan bakteri Staphylococcus aureus. Penelitian ini dilakukan dengan menggunakan metode eksperimental murni. Metode yang digunakan dalam uji aktivitas antibakteri adalah metode difusi dengan kertas cakram. Konsentrasi yang digunakan pada ekstrak daun labu siam terdiri dari konsentrasi 20%, 40%,dan 60%. Hasil skrining fitokimia menunjukkan bahwa ekstak daun labu siam mengandung saponin, flavonoid, dan tanin. Pengaruh pemberian ekstrak daun labu siam terhadap Staphylococcus aureus ditandai dengan terbentuknya zona hambat pada konsentrasi 20%, 40%, dan 60% secara berurutan dengan rerata diameter sebesar 6,6 mm; 8,5 mm; 10,3 mm. Hasil uji One-Way ANOVA didapatkan nilai sig 0,000 (sig<0,05) dan berdasarkan hasil penelitian dapat disimpulkan bahwa terdapat pengaruh konsentrasi ekstrak daun labu siam terhadap pertumbuhan bakteri Staphylococcus aureus. Konsentrasi 60% yang paling efektif dalam menghambat pertumbuhan bakteri dengan potensi kuat dalam menghambat pertumbuhan bakteri Staphylococcus aureus dengan mengunakan metode difusi. Disarankan pada peneliti selanjutnya untuk melakukan uji aktivitas antibakteri pada bagian tumbuhan yang lain seperti bunga, batang dan akar. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2020-10-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/499 10.35451/jfm.v3i1.499 JURNAL FARMASIMED (JFM); Vol. 3 No. 1 (2020): Jurnal Farmasimed (JFM); 32-38 Jurnal FARMASIMED (JFM); Vol 3 No 1 (2020): Jurnal Farmasimed (JFM); 32-38 2655-0814 10.35451/jfm.v3i1 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/499/272 Copyright (c) 2020 Cucu Arum Dwi Cahya, Ayunda Priasa, Nur Ulina M. Br. Turnip

oai:ejournal.medistra.ac.id:article/524 2023-11-23T04:23:37Z JFM:YRS

PERBANDINGAN AKTIVITAS ANTIBAKTERI INFUSA DAUN JERUK NIPIS (CITRUS AURANTIFOLIA) DAN DAUN JERUK PURUT (CITRUS HYSTRIX) TERHADAP BAKTERI ESCHERICHIA COLI Siregar, Saadah Indriani, Indriani Vincentia Ade Rizky, Vincentia Visensius Krisdianilo, Visensius Anna Teresia Marbun, Romauli Antibacterial, Leaf Lime, Kaffir Lime Leaves, Escherichia coli Plant Lime (Citrus aurantifolia) and Plant Kaffir Lime (Citrus hystrix) including Rutacea family. Part of the plant lemon and lime are used as a drug other than fruit and leaves that can be used as medicine. This study aims to determine the antibacterial activity infuse lime leaves and lime leaves. Examination of the characteristics simplicia macroscopic examination. Phytochemical screening of compounds includes examining alkaloids, flavonoids, tannins and infuse saponin. Ekstrak conducted using distilled water solvent. Test of antibacterial activity against Escherichia coli bacteria carried by the agar diffusion method using a paper disc. Results obtained from macroscopic examination for lime leaves are fresh leaves leaf-shaped single smooth surface and the lower surface of the leaves are light green, the dark green upper surface. If torn, lime leaves produce coarse fibers. The leaves are small with a width of 3-5 cm. For lime leaves are fresh leaves, leaf litter pinnate compound leaves one. Child leaf blade oval to oblong, base rounded or blunt, the blunt end up pointed, 8-15 cm long, 2-6 cm wide, the upper surface colour some what shiny dark green, light green below the surface. Results of phytochemical screening simplicia powder lime leaves and lime leaves that contain a class of alkaloids, flavonoids and tannins. Antibacterial activity test results showed that there were differences between the antibacterial infusion lime leaves and lime leaves kaffir lime leaves which are more effective against the bacteria Escherichia coli compared kaffir lime leaves. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2020-10-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/524 10.35451/jfm.v3i1.524 JURNAL FARMASIMED (JFM); Vol. 3 No. 1 (2020): Jurnal Farmasimed (JFM); 39-46 Jurnal FARMASIMED (JFM); Vol 3 No 1 (2020): Jurnal Farmasimed (JFM); 39-46 2655-0814 10.35451/jfm.v3i1 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/524/273 Copyright (c) 2020 Saadah Siregar

oai:ejournal.medistra.ac.id:article/567 2023-11-23T04:22:47Z JFM:YRS

EVALUASI KUALITATIF PENGGUNAAN ANTIBIOTIK CEFTRIAXONE PADA PASIEN DEMAM TYFOID ANAK RUANGAN RAWAT INAP RSUD DELI SERDANG Rahayu, Yayuk Suyudi Wulandari, Suci Anjar Pangestuti, Titi Quality of Antibiotic Use, Child Typhoid Fever, Ceftriaxone Typhoid fever is a systemic infection caused by the salmonella thypi bacteria which attacks the small intestine with fever for 1 week or more accompanied by disturbances in the digestive tract. This disease is endemic and is a community disease that is transmitted through food and drink contaminated with bacteria. Typhoid fever can be treated using antibiotics, giving antibiotics especially in children and infants must consider the side effects on body systems and organ function that are still not perfect. The purpose of this study was to determine the use of ceftriaxone antibiotics based on the right indication, the right patient, the right drug, the right dose, the right time of administration and the right way of giving antibiotics in the inpatient installation of the Deli Serdang Regional General Hospital in 2019.      This study used retrospective data and was analyzed descriptively by purposive sampling method. Data used by pediatric patients (2-12 years). Data according to the inclusion characteristics of 43 cases were evaluated for their quality based on the right indication, the right patient, the right drug, the right dose, the right time of administration and the right way of administration.      The results of this study indicate that the percentage of the quality of antibiotic use includes 43 (100%) right indications, 43 (100%) right patients, 43 (100%) right drugs, 30 (73%) right doses, 42 right time of administration ( 97.67%) and the right way of giving was 43 (100%). Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2021-04-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/567 10.35451/jfm.v3i2.567 JURNAL FARMASIMED (JFM); Vol. 3 No. 2 (2021): Jurnal Farmasimed (JFM); 47-52 Jurnal FARMASIMED (JFM); Vol 3 No 2 (2021): Jurnal Farmasimed (JFM); 47-52 2655-0814 10.35451/jfm.v3i2 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/567/295 Copyright (c) 2021 Yayuk Suyudi Rahayu, Suci Wulandari, Titi Anjar Pangestuti

oai:ejournal.medistra.ac.id:article/570 2023-11-23T04:22:47Z JFM:YRS

FORMULASI SEDIAAN LOTION EKSTRAK ETANOL BIJI KOPI ROBUSTA (Coffea cenephora) Wati, Erda cahya, uci dwi Darmirani, Yosi Robusta coffee bean extract (Coffea canephora) lotion Bean robusta coffee contains polyphenol compounds which are useful as antioxidants. Antioxidants can inactivate the development of oxidation reactions, by preventing the formation of free radicals. Robusta coffee bean plant (Coffea canephora) is an ingredient that can be formulated into lotion preparations. Cosmetic lotion aims to remove dead skin cells, brighten the skin and soften the skin. This research is to make lotion preparations from robusta coffee bean extract (Coffea Canephora) . This research uses pure experiment. Robusta coffee beans are extracted by maceration process. The lotion formulation is made with variations of robusta coffee bean powder (Coffea Canephora) with a concentration of 2%, 3%, and 4%. The characteristic test includes organoleptic test, homogeneity test, Ph test, and irritation test. The purpose of this study was to determine the lotion formulation for robusta coffee bean extract (Coffea Canephora). The results of the lotion test had a homogeneous concentration of 2%, 3% and 4%, light brown to blackish brown, with a distinctive smell of coffee. The ph lotion test had a PH of 5 in all formulations on the blank had a PH of 6. The irritation test on the lotion preparation showed no erythema and edema in 5 volunteers. From all the tests carried out, the lotion formulation has good characteristics. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2021-04-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/570 10.35451/jfm.v3i2.570 JURNAL FARMASIMED (JFM); Vol. 3 No. 2 (2021): Jurnal Farmasimed (JFM); 53-56 Jurnal FARMASIMED (JFM); Vol 3 No 2 (2021): Jurnal Farmasimed (JFM); 53-56 2655-0814 10.35451/jfm.v3i2 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/570/296 Copyright (c) 2021 Erda Wati, uci dwi cahya, Yosi Darmirani

oai:ejournal.medistra.ac.id:article/571 2023-11-23T04:22:47Z JFM:YRS

EFEKTIVITAS FORMULASI SEDIAAN LOTION DARI EKSTRAK ETANOL DAUN ALPUKAT (PERSEA AMERICANA MILL) SEBAGAI PELEMBAB KULIT Novasari, Hastrina Pratiwi, Asti Mahmiara, Nopri Avocado Leaf Extrach, Skin Moisture, Skin Moisturizing Lotion Avocado plant can be formulated into a lotion because preparation based on previous research avocado leavescontain high antioxidant is represented with flavonoid compound. The purpose of this study is to know avocado leaves can be formulated into the preparation of lotion and to know the preparation of lotion from extract etanol avocado leavescan moisturaize the skin. The research uses exsperimental method. Avocado leaves is exstrach by maceration process. Exanination of lotion preparation by this research is phytochemical screening test, pH test,irritation test and skin moisturaise test with concentration 3% and 5%. Extrach ethanol avocado leaves can be formulated into a skin  moisturaizing lotion preparation with irritation test results showed no irritation on the skin, skin moisture examination result concentration 5% moist. The result showed that moisturaizing lotion preparation from avocado leaves ethanol extrach (Persea americana Mill) for skin moisture with different concentration can be formulated into skin moisturaizing lotion preparation Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2021-04-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/571 10.35451/jfm.v3i2.571 JURNAL FARMASIMED (JFM); Vol. 3 No. 2 (2021): Jurnal Farmasimed (JFM); 57-62 Jurnal FARMASIMED (JFM); Vol 3 No 2 (2021): Jurnal Farmasimed (JFM); 57-62 2655-0814 10.35451/jfm.v3i2 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/571/297 Copyright (c) 2021 Hastrina Novasari, Asti Pratiwi, Nopri Mahmiara

oai:ejournal.medistra.ac.id:article/574 2023-11-23T04:22:47Z JFM:YRS

DRP EVALUASI DRUNG RELATED PROBLEMS (DRPs) ANTIBIOTIK PADA PASIEN PNEUMONIA RAWAT INAP ANAK RUMAH SAKIT UMUM DAERAH DELI SERDANG Monica, Cindy S, Aminah. Dalilla, Siti Drung Related Problems (DRPs), Antibiotics, Pneumonia Background: Infection is one of the top ten diseases in Indonesia, so that antibiotic therapy is quite high. The increasing use of antibiotics may lead to an increase in the use of irrational antibiotics. Drug Related Problems (DRPs) are events that are not expected from the patient's experience or are suspected to be due to drug therapy so that they have the potential to interfere with the desired healing success. Objective: This study aims to determine the number of occurrences of DRPs which include dosage inaccuracy, namely under and over dose, indication without drug, drug without indication, potential interactions and inaccuracy of drug selection in inpatient pneumonia treatment for children at the Deli Serdang Regional public hospital. In 2019 Method: This study is retrospective in which data is obtained through secondary data in the form of patient medical records for the period January-December 2019 with a cross-sectional study design. The data collection technique was in the form of total sampling, obtained 50 samples that fit the inclusion criteria. Results: Drung Related Problems (DRPs) research that occurred in the under-dose category of drugs (4.0%), and excessive drug doses (2.0%) and no DRPs (94.0%). This shows that the role of pharmacists is important in monitoring patient drug therapy to minimize the occurrence of DRPs. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2021-04-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/574 10.35451/jfm.v3i2.574 JURNAL FARMASIMED (JFM); Vol. 3 No. 2 (2021): Jurnal Farmasimed (JFM); 63-68 Jurnal FARMASIMED (JFM); Vol 3 No 2 (2021): Jurnal Farmasimed (JFM); 63-68 2655-0814 10.35451/jfm.v3i2 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/574/298 Copyright (c) 2021 Cindy Monica, Aminah. S, Siti Dalilla

oai:ejournal.medistra.ac.id:article/576 2023-11-23T04:22:47Z JFM:YRS

EVALUASI PENGGUNAAN OBAT ANTITUBERKULOSIS (OAT) PADA PASIEN TB PARU DI RUMAH SAKIT GRANDMED LUBUK PAKAM TAHUN 2020 Sinulingga, Amanda Safithri Boru Situmorang, Novidawati Gabena Siregar, Mas Oat Drugs, Rs Granmed Lubuk Pakam. Tuberculosis is a disease caused by the bacterium Mycobacterium tuberculosis, a first- line anti-tuberculosis drug, namely Isoniazid (H) and Rifampicin (R). The increase in the number of Tb Lung patients from 2019 to 2020 at the RS Grandmed Lubuk Pakam encouraged researchers to conduct this study. The purpose of this study was to determine the description of the use of antituberculosis drugs and the rationality of the use of anti-tuberculosis drugs in pulmonary TB patients in RS Grandmed Lubuk Pakam in 2019. This study was a descriptive (non-experimental) study with retrospective data collection taken from patient medical records. Pulmonary tuberculosis at RS Grandmed Lubuk Pakam. Data was collected using purposive sampling technique in accordance with the inclusion criteria and exclusion criteria using the Data Collection Sheet. The number of samples used in the study is 76 medical records of patients diagnosed with pulmonary TB. Data analysis was performed using the Univariate with the help of SPSS. Results of the distribution of treatment duration data that most patients underwent treatment for <6 months, as many as 31 people (19.9%). Followed by patients with exactly 6 months length of 30 people (0.39%). Whereas patients from 6 months 16 people (21.1%). And the number of Chronic Disease that suffered by Diabetes Mellitus patients was 24 patients (14.5%). All three have a significant relationship to the patient's treatment outcomes. Whereas at the age range 18-24 years, 44 people (57.9%) were affected by pulmonary TB. and The results of the evaluation of the rationality of pulmonary TB treatment are the exact indications of (97.4%), (74 patients), the right patients by 100% (76 patients), the right drugs by (97.4%) (74 patients), and the correct dosage of 100% ( 76). Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2021-04-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/576 10.35451/jfm.v3i2.576 JURNAL FARMASIMED (JFM); Vol. 3 No. 2 (2021): Jurnal Farmasimed (JFM); 69-73 Jurnal FARMASIMED (JFM); Vol 3 No 2 (2021): Jurnal Farmasimed (JFM); 69-73 2655-0814 10.35451/jfm.v3i2 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/576/299 Copyright (c) 2021 Amanda Safithri Sinulingga, Novidawati Boru Situmorang, Mas Gabena Siregar

oai:ejournal.medistra.ac.id:article/577 2023-11-23T04:20:06Z JFM:YRS

EVALUASI PENGGUNAAN OBAT GASTRITIS PADA PASIEN RAWAT INAP DI RS GRANDMED LUBUK PAKAM TAHUN 2020 Mayasari, Dini Hutahean, Delfi Mutiara Octora, Debi Dinha RS Grandmed Lubuk Pakam Medicine Gastritis Hospital of Pharmacy Gastritis is a disease caused by the bacterium Helicobacter phylory, this first gastritis drug, namely Antacids, Omeprazole, and Ranitidine. The increasing number of Gastritis patients from 2019 to 2020 at Grandmed Lubuk Pakam Hospital is encouraging researchers to conduct this study. The purpose of this study was to determine the description of the use of Gastritis drugs and the rationality of the use of Gastritis medications in Gastritis patients at Grandmed Lubuk Pakam Hospital in 2019. This study was a descriptive (non-experimental) study with retrospective data collection taken from patient medical records. Gastritis at Grandmed Lubuk Pakam Hospital. Data were collected using a purposive sampling technique in accordance with the inclusion criteria and exclusion criteria using the Data Collection Sheet. The number of samples used in this study were 64 medical records of patients diagnosed with gastritis. Data analysis was performed using Univariat with the help of SPSS. Results of distribution of duration of treatment data for which most patients undergo treatment. And the number of Chronic Diseases suffered by Diarrhea patients is 20 patients (31.2%). All three have a significant relationship with patient care outcomes. While in the age range 31-60 years, 45 people (70.3%) affected by gastritis. and The results of evaluating the rationality of treatment for gastritis are the right indications (96.9%), (62 patients), 100% correct patients (64 patients), the right medication by (96.9%) (62 patients), and the correct dosage 100% correct (64). Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2021-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/577 10.35451/jfm.v4i1.577 JURNAL FARMASIMED (JFM); Vol. 4 No. 1 (2021): Jurnal Farmasimed (JFM); 1-6 Jurnal FARMASIMED (JFM); Vol 4 No 1 (2021): Jurnal Farmasimed (JFM); 1-6 2655-0814 10.35451/jfm.v4i1 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/577/423 Copyright (c) 2021 Dini Mayasari, Delfi Mutiara Hutahean, Debi Dinha Octora

oai:ejournal.medistra.ac.id:article/582 2023-11-23T04:22:47Z JFM:YRS

EFEKTIVITAS KERASIONALAN PEMBERIAN ANTIDIABETIK PENGOBATAN ORAL PASIEN DIABETES MELLITUS PADA USIA 30-50 TAHUN TIPE 2 DI RAWAT INAP PENYAKIT DALAM RSUD DELI SERDANG LUBUK PAKAM TAHUN 2020 Sebayang, Loraetta Brety Anna Teresia Marbun, Romauli Kartika, Dewi Effectiveness of drug rationality diabetes mellitus antidiabetic Background: Diabetes Mellitus is a chronic condition, which occurs because the body cannot produce insulin, normally or insulin cannot work effectively. Objective: To determine the effectiveness of the rational administration of antidiabetic, oral treatment of diabetes mellitus patients at the age of 30-50 years type 2 in Deli Serdang Hospital, lubuk pakam in 2020. Method: This study is a non-experimental type of research using descriptive methods. Results: Shows that from 72 samples of Type II Diabetes Mellitus patients at Deli Serdang General Hospital, April-July Period 2020. With the number (52.8%) of male sex patients and the number (47.2%) of type patients  female genitalia and antidiabetic drugs most widely used by patients, in the period of April-July 2020, namely (20.8%) glycionion + metformin and (20.8%) insulin drugs.  the use of DM drugs with the right rational indication (65.3%), Rational with the right medicine (100%), rational with the right dosage (100%), the right rational patient (100%) and the rational way of administration (100:%). Conclusion: Evaluation of drug use is a structured quality assurance process that is carried out continuously to ensure that the drugs used are appropriate, safe, and efficient. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2021-04-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/582 10.35451/jfm.v3i2.582 JURNAL FARMASIMED (JFM); Vol. 3 No. 2 (2021): Jurnal Farmasimed (JFM); 74-80 Jurnal FARMASIMED (JFM); Vol 3 No 2 (2021): Jurnal Farmasimed (JFM); 74-80 2655-0814 10.35451/jfm.v3i2 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/582/300 Copyright (c) 2021 Loraetta Brety Sebayang, Romauli Anna Teresia Marbun, Dewi Kartika

oai:ejournal.medistra.ac.id:article/591 2023-11-23T04:22:47Z JFM:YRS

UJI EFEKTIFITAS DAUN PANDAN WANGI (PANDANUS AMARYLLIFOIUM ROXB) SEBAGAI ANTIJAMUR TERHADAP PITYSPORUM OVALE siregar, Saadah Topia, Riana Fragrant Pandan Leaves (Pandanus amaryllifolius Roxb.), Pityrosporum ovale The Pandan Wangi leaf plant is a plant that belongs to the Pandanaceae family. The metabolite content of fragrant pandan leaves (Pandanus amaryllifolius  Roxb.) Alkaloids, flavonoids, saponins, tannins are known to have an antifungal effect. Pityrosporum ovale is a yeast or single-celled fungus that belongs to the genus Malassezia sp, and belongs to the Cryptococcaceae family. Pityrosporum ovale causes superficial dermatomycosis which affects the stratum corneum in the epidermis layer. This fungus is a normal flora on the scalp, but in conditions of hair with excess oil glands, this fungus can thrive. The purpose of this study was to determine the inhibition zone of fragrant pandanus leaves (Pandanus amaryllifolius Roxb.) Concentrations of 10%, 20%, 30%, and 40% of Pytirosporum ovale on Potato Dextrose Agar media by diffusion method using disc paper. The diffusion method was used to measure the diameter of the zone of inhibition against fungal growth. The positive control used was ketoconazole 2% and negative control DMSO 1%. The results of the study using the diameter of the inhibition zone at a concentration of 10% were 7.86 mm, the inhibition zone at a concentration of 20% was 8.53 mm, the inhibition zone at a concentration of 30% was 8.76 mm, and the inhibition zone at a concentration of 40% was 9, 43 mm. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2021-04-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/591 10.35451/jfm.v3i2.591 JURNAL FARMASIMED (JFM); Vol. 3 No. 2 (2021): Jurnal Farmasimed (JFM); 81-85 Jurnal FARMASIMED (JFM); Vol 3 No 2 (2021): Jurnal Farmasimed (JFM); 81-85 2655-0814 10.35451/jfm.v3i2 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/591/301 Copyright (c) 2021 saadah siregar, Riana Topia

oai:ejournal.medistra.ac.id:article/596 2023-11-23T04:22:47Z JFM:YRS

PERBEDAAN EFEK MINUMAN BERKARBONASI DENGAN MINUMAN PROBIOTIK TERHADAP PERUBAHAN GAYA Z-SPRING saragih, jean Muttaqin, Zulfan LINA HADI, LINA Probiotic, carbonation drink, orthodontic z- spring, resilience The effect of the drink can cause changes in the resilience of the wire which is usually due to carbonated drinks or probiotics Carbonated beverage is a daily drinks with carbonic acid and has pH of 2.32. Carbonated beverage with lower pH may cause the releasing of nickel (Ni) and chromium (Cr) ions on stainless steel orthodontic wire in oral cavity and result in alteration of resilience. Purpose: The aim of this research is to know the change of resilience of stainless steel removable orthodontic wire before and after immersion with ,probiotic,carbonated beverages and saline solution. Material and methods: This study is true experimental study using pre and post test with control group design, consist of 9  treatment groups and  control groups were obtained from preliminary test, each group using stainless steel ortodontic wire with the diameter is 0.6 mm and given a scratch along the wire then perform the resilience before and after the immersion using a UTM. Each sample was immersed and put in an incubator at 37oC for the first 4 days then measured with a UTM device then soaked again for the next 4 days and measured again. Research result: The results showed that there were differences in the resilience of the wires on day 0 and day 4 when immersed in carbonated drinks (p = 0.047) compared to soaking saliva and probiotics. Then z-spring stainless steel orthodontic wire soaked in probiotic obtained p value = 0.038. This shows that there is a difference in the resilience of the 8th day compared to the 0th day.Conclusion: Results Soaking stainless steel orthodontic wire changes its resilience. There was a significant difference between day 4 and day 8 for the wire soaked in carbonated drinks (p = 0.001). there is no significant difference in the wire soaked with probiotic drinks. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2021-04-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/596 10.35451/jfm.v3i2.596 JURNAL FARMASIMED (JFM); Vol. 3 No. 2 (2021): Jurnal Farmasimed (JFM); 86-92 Jurnal FARMASIMED (JFM); Vol 3 No 2 (2021): Jurnal Farmasimed (JFM); 86-92 2655-0814 10.35451/jfm.v3i2 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/596/302 Copyright (c) 2021 jean saragih, Zulfan Muttaqin

oai:ejournal.medistra.ac.id:article/597 2023-11-23T04:22:47Z JFM:YRS

EFEK KATEKIN DAUN GAMBIR (UNCARIA GAMBIR ROXB) TERHADAP KADAR MALONDIALDEHID SERUM DAN EKSPRESI GEN SIRTUIN 1 PADA HIPOKAMPUS MENCIT BETINA MODEL PENUAAN Situmorang, Novrina ., Zulham Feryawati, Lita Aging Malondialdehyde Sirtuin 1 Catechin Aging is a physiological process characterized by progressive loss of physiological integrity that leads to impaired function and increased susceptibility to death. Oxidative stress is one of the factors that cause aging due to an imbalance between the amount of oxidants and antioxidants. In oxidative stress condition, malondialdehyde levels increase. D-galactose can induce aging in various organ systems. D-galactose induces oxidative stress in various organs through increased production of reactive oxygen species (ROS) and advanced glycation endproducts. In oxidative stress condition, sirtuin1 (Sirt1) produces ribose O-acetyl-ADP which, later, is reduced into ribose ADP. Both of them have a protective effect against oxidative stress. Consumption of antioxidants may prevent aging. Gambir contains health-promoting ingredients such as catechins. This study aims to determine the effect of gambier leaves catechin extract on serum malondialdehyde levels and the expression of sirtuin 1 gene in female mice aging model induced by d-galactose. This is an in vivo experiment with post test-only control group study. The samples were 28 female mice which were divided into 4 groups namely P0, P1, P2, and P3. Each group was injected 150 mg/kgBW d-galactose intraperitoneally. P1, P2, and P3 were treated orally with 100, 200, and 400 mg/kgBW gambir leaves catechin extract, respectively. Statistical test use descriftive analisys. There were significant differences in serum MDA levels in all groups (p=0.002) and there were significant differences between the P0 and P2 groups (p=0.010) and between the P0 and P3 groups (p=0.010). Sirtuin1 gene relative expressions decresead in P1 (0,49), P2 (0,74), and  P3 (0,43) as compared to P0 (1.00). Conclusion. Gambir leaves catechin extract reduces serum malondialdehyde levels in aging mouse models induced by d-galactose with an optimal dose of 200mg/kgBW.  and cannot reduce the relative expression of Sirt1 Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2021-04-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/597 10.35451/jfm.v3i2.597 JURNAL FARMASIMED (JFM); Vol. 3 No. 2 (2021): Jurnal Farmasimed (JFM); 93-99 Jurnal FARMASIMED (JFM); Vol 3 No 2 (2021): Jurnal Farmasimed (JFM); 93-99 2655-0814 10.35451/jfm.v3i2 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/597/303 Copyright (c) 2021 Novrina Situmorang, Zulham ., Lita Feryawati

oai:ejournal.medistra.ac.id:article/615 2023-11-23T04:22:47Z JFM:YRS

IDENTIFIKASI BAKTERI ESCHERICHIA COLI O157:H7 PADA FESES PENDERITA DIARE DENGAN METODE KULTUR DAN PCR Rizky, Vincentia Ade Siregar, Sa’adah Krisdianilo, Visensius Rahayu, Asvia Syafrina Ginting, Suventi ., Kartini Escherichia coli O157:H7, PCR, Culture method Escherichia coli O157: H7 is the main cause of foodborne disease in several countries, one of which is diarrhea. Diarrheal disease is still a major problem in Indonesia that needs treatment and study from various aspects. The conventional method of laboratory examination such as culture is a method that is often carried out, but in making the diagnosis requires a long time, the number of samples is large, and the results are less accurate because contamination can occur. Another more accurate technique for detecting Escherichia coli O157: H7 is the PCR technique. This study aims to identify the Escherichia coli O157: H7 bacteria by culture method and PCR. The results showed that the culture method and PCR of 8 isolated samples 4 showed positive results for the bacterium Escherichia coli O157: H7. However, the PCR method is more selective and faster than the culture method. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2021-04-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/615 10.35451/jfm.v3i2.615 JURNAL FARMASIMED (JFM); Vol. 3 No. 2 (2021): Jurnal Farmasimed (JFM); 118-123 Jurnal FARMASIMED (JFM); Vol 3 No 2 (2021): Jurnal Farmasimed (JFM); 118-123 2655-0814 10.35451/jfm.v3i2 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/615/330 Copyright (c) 2021 VINCENTIA ADE RIZKY

oai:ejournal.medistra.ac.id:article/616 2023-11-23T04:20:06Z JFM:YRS

KARAKTERISASI DAN IDENTIFIKASI MOLEKULER BAKTERI PENGHASIL ENZIM PROTEASE DARI TEMPE YANG DIPERJUALBELIKAN DI PASAR LUBUK PAKAM Krisdianilo, Visensius Siregar, Sa'adah Rizky, Vincentia Ade Bacterial, Enzyme Protease, Pseudomons stuastzeri , Tempe Protease enzyme is an enzyme that is important in protein breakdown. Animals, plants as well as microorganisms such as bacteria can produce this protease enzyme. In its application protease enzymes can be used in the pharmaceutical industry, detergent industry, skin products as well as food products. Tempe is one of the traditional food products that have been known for a long time, tempeh is made from soybean seeds fermented by mushrooms. Molecular identification can use polymerase chain reaction (PCR) method, PCR is the process of multiplying a certain nucleotide sequence using enzymatic processes in vitro. The presence of protein content in tempeh can be possible the presence of bacteria that can break down proteins in the tempeh, especially tempeh that has been fermented about 48-72 hours. Based on the results of characterization and identification of 5 isolates of tempeh post-fermentation 72 hours, positive results of protease enzymes found in isolate TPLP-1, TPLP-2 and TPLP-5, with the largest zone diameter in isolate TPLP-2 50 mm, then isolate with the highest protease enzyme activity isolate TPLP-2 molecularly identified by identifying the gene 16S rRNA which is subsequently included in the BLAST program and obtained by isolate TPLP-2 identified as Pseudomons stuastzeri. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2021-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/616 10.35451/jfm.v4i1.616 JURNAL FARMASIMED (JFM); Vol. 4 No. 1 (2021): Jurnal Farmasimed (JFM); 7-13 Jurnal FARMASIMED (JFM); Vol 4 No 1 (2021): Jurnal Farmasimed (JFM); 7-13 2655-0814 10.35451/jfm.v4i1 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/616/424 Copyright (c) 2021 Visensius Krisdianilo, Sa'adah Siregar, Vincentia Ade Rizky

oai:ejournal.medistra.ac.id:article/624 2023-11-23T04:22:47Z JFM:YRS

GAMBARAN SEL EPITEL PADA LESI PAYUDARA DILABORATORIUM PATOLOGI ANATOMI UPT RSUD DELI SERDANG LUBUK PAKAM ., Kartini Krisdianilo, Visensius Sumantri, Bambang Sidabutar, Rimayani Lesi Payudara, Sel epitel The breast is an organ that grows as a tissue bulge that is first seen at 7 to 8 weeks after conception. Each breast consists of 12 to 20 tubuloalveolar gland lobules. Each lobule consists of cells consisting of cube epithelial cells and myoepithelial cells that surround the lumen. Lesions in the breast can originate from a connective tissue or from epithelial cells that develop continuously. Some types of epithelial cell traces in breast lesions include fibroadenoma, tumor filoides, papillomas, and papillary carcinoma, and breast carcinoma. This study aims to determine the description of epithelial cells in breast lesions in the Anatomical Pathology Laboratory of UPT Deli Serdang Lubuk Pakam Hospital Period 2018 - 2019. The research was conducted descriptively using the Fine Needle Aspiration Biopsy (FNAB) examination method. The study was conducted using secondary obtained from the medical record of the Anatomical Pathology Laboratory of UPT Deli Serdang Lubuk Pakam Hospital about the description of epithelial cells in breast lesions. The results showed that there were 6 epithelial cell features in breast lesions in the Anatomy Pathology Laboratory of UPT Deli Serdang Hospital. The six epithelial cell features include mammary aberans, mammary adenoma fibrio, mammary dysplasia, mammary multiple fibroadenoma, mammary ductal hyperplasia and mammary carcinoma. From a total of 30 study samples obtained 14 epithelial cells in the form of mammary adenoma fibrio (46.67%). Description of epithelial cells in the form of mammary aberans as many as 7 people (23.33%). For depictions of epithelial cells in the form of mammary carcinoma by 6 people (20%). While the epithelial picture in the form of mammary dysplasia, multiple fibroadenoma mammary and mammary ductal hyperplasia each as much as 1 person (3.33%). Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2021-04-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/624 10.35451/jfm.v3i2.624 JURNAL FARMASIMED (JFM); Vol. 3 No. 2 (2021): Jurnal Farmasimed (JFM); 100-106 Jurnal FARMASIMED (JFM); Vol 3 No 2 (2021): Jurnal Farmasimed (JFM); 100-106 2655-0814 10.35451/jfm.v3i2 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/624/304 Copyright (c) 2021 kartini ., Visensius Krisdianilo, Bambang Sumantri, Rimayani Sidabutar

oai:ejournal.medistra.ac.id:article/669 2023-11-23T04:20:06Z JFM:YRS

DIAGNOSA VIBRIO CHOLERAE DENGAN METODE KULTUR DAN PCR PADA SAMPEL SUMBER AIR MINUM Yusnita, Desi Krisdianilo, Visensius Vibrio cholera, PCR Acute diarrhea due to infection can be caused by a bacterial, viral or parasitic infection. One of the bacteria that causes diarrhea is Vibrio cholerae and usually the diarrhea caused is called cholera diarrhea. Cholera diarrhea is caused by enterotoxins produced by V. cholerae bacteria and forms colonies inside the small intestine. Symptoms include vomiting, defecation such as large amounts of rice water resulting in dehydration, electrolyte loss and increased blood acidity. In severe cases, the sufferer continuously defecates accompanied by vomiting, so that the sufferer will lose fluids and electrolytes quickly from the gastrointestinal tract. This leads to a rationing of metabolic acidity and when left untreated can lead to death. V. cholerae bacteria are not invasive, do not enter the bloodstream but remain in the intestinal tract. At the time of infection through contaminated food and beverages ingested, then after passing through the stomach acid defense V. cholerae produces two virulence factors that cause cholera, namely coregulated pilus toxin (TCP) and cholera toxin (CT). The existence of specific enterotoxin cholera only found in V. cholerae pathogens can be targeted in laboratory tests for the diagnosis of pathogenic V. cholerae bacteria using biomolecular techniques such as polymerase chain reaction (PCR) methods. From the results of the examination of drinking water samples at the drinking water depot around the bottom of the pakam, obtained the results of the PCR examination confirmed by electrophorensis is 302 bp, which means that in the sample there are bacteria that are identic with Vibrio cholera. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2021-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/669 10.35451/jfm.v4i1.669 JURNAL FARMASIMED (JFM); Vol. 4 No. 1 (2021): Jurnal Farmasimed (JFM); 14-18 Jurnal FARMASIMED (JFM); Vol 4 No 1 (2021): Jurnal Farmasimed (JFM); 14-18 2655-0814 10.35451/jfm.v4i1 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/669/425 Copyright (c) 2021 Desi Yusnita, Visensius Krisdianilo

oai:ejournal.medistra.ac.id:article/678 2023-11-23T04:22:47Z JFM:YRS

PENGARUH LILIN AROMATERAPI MINYAK LAVENDER (LAVANDULA ANGUSTIFOLIA) TERHADAP KONSENTRASI BELAJAR PADA SISWA MADRASAH TSANAWIYAH AL-WASHLIYAH PASAR MIRING DI DESA PASAR MIRING anggraeni, Ratih ., Muriati Pranata, Chandra aromaterapy, candle oil atsiri lavender Aromatherapy is an ancient healing process that uses pure aromatherapy plant extracts aimed at improving the health and well-being of the body, mind and spirit. Lavender contains linalil acetate and linalool. Linalil acetate and linalool have no harmful side effects on health. This substance is antibacterial, fungicidal, viriside, parasiticidal and vermifugal and has neurotonic and uterotonic action. This study aims to determine the effect of lavender oil (Lavandula angustifolia) aromatherapy candles on increasing the concentration of student learning at the Madrasah Tsanawiyah Al-Wasliyah Pasar Miring in Desa Pasar Miring . The study used a quasi-pretest-posttest experimental method for 30 randomly selected students. The instrument in this study used the Army Alpha Test with data analysis using Paired T-Test. Hypothesis testing using Paired T-Test showed p value = 0.026<0.05 (p <0.05). It can be concluded that there is an influence of lavender oil aromatherapy candles on increasing the concentration of student learning in Madrasah Tsanawiyah Al-Wasliyah Pasar Miring in Desa Pasar Miring Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2021-04-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/678 10.35451/jfm.v3i2.678 JURNAL FARMASIMED (JFM); Vol. 3 No. 2 (2021): Jurnal Farmasimed (JFM); 107-112 Jurnal FARMASIMED (JFM); Vol 3 No 2 (2021): Jurnal Farmasimed (JFM); 107-112 2655-0814 10.35451/jfm.v3i2 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/678/305 Copyright (c) 2021 Ratih anggraeni, Muriati ., Chandra Pranata

oai:ejournal.medistra.ac.id:article/681 2023-11-23T04:22:47Z JFM:YRS

EVALUASI PENGGUNAAN OBAT ASAM URAT DAN POLA PERESEPANNYA PADA PASIEN GOUT ARTRITIS DI INSTALASI RAWAT INAP DI RSUD DELI SERDANG LUBUK PAKAM TAHUN 2020 Rahayu, Asvia Anna Teresia Marbun, Romauli Nopita Sari Manalu, Dian Siregar, Sa’adah Ade Rizky, Vincentia Krisdianilo, Visensius Gout Artritis, Obat Asam Urat, Peresepan Obat, Sendi, Inflamasi Uric acid is a disease that arises due to excess purine in the body caused by uric crystals in the joint tissue that attacks the fingers, elbows, knees, toes, toes and heels. Gouty arthritis is a progressive disease caused by deposition of monosodium urate crystals (MSU) found in the joints, kidneys, and other connective tissue due to chronic hyperuricemia. The incidence of gouty arthritis is common in men as many as 25 patients (65.8%) and women as many as 13 patients (34.2%). The incidence of gouty arthritis continues to increase with age, at the age of 21-35 years (7.9%), ages 36-55 years (36.7%), age 56-65 years (28.9%), and at the age of 66 -75 years (26.3%). The purpose of this study was to examine the use of uric acid and its prescription patterns in arthritis patients in Deli Serdang Lubuk Pakam Hospital in 2020 in terms of the right parameters according to the indications, the right patients, the right drugs, and the right dosages. This research is a non-experimental study, data retrospective retrieval was done by looking at the medical record data of arthritis gout patients and analyzed descriptively. Sampling as many as 38 patients with puposive sampling method. Inclusion criteria in this study were patients who were diagnosed with gout and given arthritis medication with complete medical record data. The results of the study evaluated the use of gout and its prescribing patterns in 38 patients at Deli Serdang Lubuk Pakam Regional Hospital in 2020, which were 100% correct, 100% right, 100% right, and 96% right. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2021-04-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/681 10.35451/jfm.v3i2.681 JURNAL FARMASIMED (JFM); Vol. 3 No. 2 (2021): Jurnal Farmasimed (JFM); 113-117 Jurnal FARMASIMED (JFM); Vol 3 No 2 (2021): Jurnal Farmasimed (JFM); 113-117 2655-0814 10.35451/jfm.v3i2 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/681/341 Copyright (c) 2021 Asvia Rahayu, Romauli Anna Teresia Marbun, Dian Nopita Sari Manalu, Sa’adah Siregar, Vincentia Ade Rizky, Visensius Krisdianilo

oai:ejournal.medistra.ac.id:article/684 2023-11-23T04:22:47Z JFM:YRS

ANTIBAKTERI SENYAWA FENOLIK DARI ALANG -ALANG (IMPERATA CYLINDRICA) Sinurat, Jhon Patar Wulandari, Suci Berutu, Rinaldo Screening, Phenolic, Antibacterial Phytochemical screening test proved that the extract of Reeds (Imperata cylindrica) contained phenolic compounds tested using 5% FeCl3 reagent. Antibacterial test using agar diffusion method against Reeds extract in DMSO solvent. The phenolic compounds obtained from the saputangan leaves Reeds extract were 36.96 grams after undergoing maceration. Reeds extract of phenolic compounds with concentrations (200; 100; 50 and 25 ppm) had strength antibacterial where the average inhibition zone of Staphylococcus aureus bacteria was 10.0 mm and the average inhibition zone was at Escherichia coli bacteria measuring 10.3 mm. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2021-04-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/684 10.35451/jfm.v3i2.684 JURNAL FARMASIMED (JFM); Vol. 3 No. 2 (2021): Jurnal Farmasimed (JFM); 124-126 Jurnal FARMASIMED (JFM); Vol 3 No 2 (2021): Jurnal Farmasimed (JFM); 124-126 2655-0814 10.35451/jfm.v3i2 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/684/331 Copyright (c) 2021 Jhon Patar Sinurat, Suci Wulandari, Rinaldo Berutu

oai:ejournal.medistra.ac.id:article/793 2023-11-23T04:20:06Z JFM:YRS

UJI AKTIVITAS ANTIBAKTERI EKSTRAK DAUN TALAS (Colococasia Esculenta L.) TERHADAP BAKTERI Escherichia coli Pranata, Chandra Tarihoran, Sartika Noviani Darmirani, Yosi Antibakteri Ekstrak Etanol Talas Eschericia coli Salah satu tanaman yang sering dijadikan obat adalah daun Talas  (Colocasia esculanta L.). Daun talas memiliki kandungan senyawa flavonoid, alkaloid, saponin dan tannin yang memiliki kemampuan untuk menghambat pertumbuhan bakteri. Eschericia coli  adalah salah satu jenis bakteri yang dapat menyebabkan infeksi pada pencernaan. Salah satu tujuan penelitian ini untuk mengetahui aktivitas antibakteri daun talas dengan konsentrasi yang paling efektif dalam menghambat bakteri Eschericia coli. Penelitian ini adalah penelitian eksperimental murni. Daun talas aktivitas antibakteri dilakukan dengan metode difusi cakram. Penelitian dilakukan dengan 3 variasi konsentrasi yang berbeda. Hasil penelitian menunjukkan bahwa ada aktivitas antibakteri pada setiap konsentrasi. Kesimpulan pemberian aktivitas daun talas dengan konsentrasi 15%, 25%, dan 35% memberikan daya hambat pertumbuhan bakteri paling efektif dengan kosentrasi 25%, 35% yang termasuk dalam kategori kuat. Saran diharapkan kepada peneliti selanjutnya dapat melakukan uji terhadap bakteri lain dan membuat formulasi dari ekstrak daun talas. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2021-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/793 10.35451/jfm.v4i1.793 JURNAL FARMASIMED (JFM); Vol. 4 No. 1 (2021): Jurnal Farmasimed (JFM); 19-24 Jurnal FARMASIMED (JFM); Vol 4 No 1 (2021): Jurnal Farmasimed (JFM); 19-24 2655-0814 10.35451/jfm.v4i1 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/793/426 Copyright (c) 2021 Chandra Pranata, Sartika Noviani Tarihoran, Yosi Darmirani

oai:ejournal.medistra.ac.id:article/801 2023-11-23T04:20:06Z JFM:YRS

FORMULASI EKSTRAK DAUN PANDAN WANGI (Pandanus amaryllifolius Roxb) SEBAGAI MASKER GEL PEEL OFF Kartika, Dewi Atikah, Lulu Pratiwi, Asti kelembapan, masker gel peel off, Pandanus amaryllifolius Pandan wangi (Pandanus amaryllifolius Roxb) adalah tanaman yang mengandung alkaloid kimia, flavonoid, tanin, dan polifenol. Penelitian ini bertujuan untuk mengetahui apakah daun pandan wangi dapat diformulasikan sebagai masker gel peel of untuk melembabkan kulit. Ekstrak daun pandan wangi dibuat dalam konsentrasi 0% (blanko), 2,5%, dan 5% yang dibuat dalam sediaan 30 gram. Uji yang dilakukanmeliputi organoleptik, homogenitas, pH, persiapan waktu kering, dan kelembapan. Hasil penelitian menunjukkan bahwa ekstrak daun pandan wangi dapat dibuat sebagai bentuk masker gel dan memenuhi evaluasi fisik bentuk. Hasil tes homogenitas menunjukkan sediaan homogen, pH dalam kisaran 6.0 yang relatif aman pada permukaan kulit wajah. Waktu persiapan mengering selama 30 menit dan memenuhi persyaratan waktu pengeringan. Kemampuan untuk melembabkan kulit lebih besar dengan meningkatkan konsentrasi ekstrak yang ditambahkan. Kemampuan rata-rata tertinggi untuk melembabkan kulit adalah 39,0%. dalam tes kelembaban konsentrasinya adalah 5% ekstrak daun harum pandan karena kulit masker gel pelembab alami sangat baik. Kesimpulannya menunjukkan bahwa ekstrak daun pandan wangi dapat diformulasikan menjadi masker gel peel off yang memiliki kemampuan melembabkan kulit. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2021-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/801 10.35451/jfm.v4i1.801 JURNAL FARMASIMED (JFM); Vol. 4 No. 1 (2021): Jurnal Farmasimed (JFM); 25-31 Jurnal FARMASIMED (JFM); Vol 4 No 1 (2021): Jurnal Farmasimed (JFM); 25-31 2655-0814 10.35451/jfm.v4i1 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/801/427 Copyright (c) 2021 Dewi Kartika, Lulu Atikah, Asti Pratiwi

oai:ejournal.medistra.ac.id:article/1006 2023-11-23T04:16:49Z JFM:YRS

EFFECTIVENNES OF SKIN EXTRACT OF POMEGRANATE (PUNICA GRANATUM L) AND OLIVE OIL AS LIP MOISTURIZING (LIP BALM) Sumitra, Jhoti Lip balm Pomegranate (punica granatum L) Olive oil softener skin analyzer Lip balm preparatios can contain active ingredients that aim to protect the lips from extreme weather and hot sun. The active ingredient added to lip balm preparations can use natural ingredients from nature or pure chemical compounds. Natural ingredients have the advantage of having minimal side effects for long-term use. So that natural ingredients are currently the prima donna in the formulation of cosmetic preparations, including lip balm preparations. The properties of pomegranate skin protect and repair lips in lip balm preparations. pomegranate peel (Punica granatum L.) as a natural colorant and utilizes olive oil (Olive oil) as an emollient or moisturizer formulated in lip balm preparations. The results showed that all homogeneous lip balm preparations had a pH of 5.6-6.1 and were stable for 12 weeks of storage. Lip balm preparations with 10% concentration of pomegranate peel extract can provide the best lip moisturizing effect to restore lip skin once a week after application for 4 weeks. All preparations of pomegranate peel extract lip balm do not irritate the skin. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2022-04-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/1006 10.35451/jfm.v4i2.1006 JURNAL FARMASIMED (JFM); Vol. 4 No. 2 (2022): Jurnal Farmasimed (JFM); 32-37 Jurnal FARMASIMED (JFM); Vol 4 No 2 (2022): Jurnal Farmasimed (JFM); 32-37 2655-0814 10.35451/jfm.v4i2 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/1006/526 Copyright (c) 2022 Jhoti Sumitra

oai:ejournal.medistra.ac.id:article/1008 2023-11-23T04:16:49Z JFM:YRS

ANTI-BACTERIAL ACTIVITY TEST OF SURGERY RHIZOME (CURCUMA DOMESTICA VAL) AGAINST BACTERIA STREPTOCOCCUS MUTANS Pratiwi, Asti Ritonga, Zulfan Hardiansyah Turmeric Extract, Streptococcus mutans, Paper disc test Abstract Turmeric (Curcuma domestica Val) contains various compounds such as alkaloids, flavonoids, curcumin, essential oils, saponins, tannins and terpenoids. The curcuminoids in turmeric rhizome are a group of phenolic compounds. Curcumin damages the cytoplasmic membrane and denatures cell proteins which causes the leakage of nutrients from the cells thereby inhibiting the growth of bacteria. The purpose of this study was to test the antibacterial activity of turmeric (Curcuma domestica Val) rhizome against Streptococcus mutans bacteria. In this study, its activity against Streptococcus mutans was seen through laboratory examination using the paper disc method. From the results of the four turmeric rhizome extracts, the average inhibition zone obtained a concentration of 10% produced an average of 14.48 mm. Concentration of 20% produces an average of 16.35 mm. concentration of 30% produces an average of 17.26 mm. Concentration of 40% produces an average of 19.47 mm. In this case, turmeric rhizome extract has strong activity against Streptococcus mutans bacteria. Turmeric rhizome contains secondary metabolites of flavonoids, alkaloids, and tannins. Which works as an antibacterial are flavonoids. Because flavonoids can inhibit nucleic acid synthesis, inhibit cell membrane function and inhibit energy metabolism. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2022-04-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/1008 10.35451/jfm.v4i2.1008 JURNAL FARMASIMED (JFM); Vol. 4 No. 2 (2022): Jurnal Farmasimed (JFM); 38-43 Jurnal FARMASIMED (JFM); Vol 4 No 2 (2022): Jurnal Farmasimed (JFM); 38-43 2655-0814 10.35451/jfm.v4i2 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/1008/527 Copyright (c) 2022 asti pratiwi, Zulfan Hardiansyah Ritonga

oai:ejournal.medistra.ac.id:article/1009 2023-11-23T04:16:49Z JFM:YRS

TEST OF ANTIBACTERIAL ACTIVITY FROM THE COMBINATION OF ETHANOL EXTRACT OF WARU (HIBUSCUSTILIACEUS L.) LEAVES AND LEAF RED PUCUK (SYZYGIUM OLEANA) AGAINST SALMONELLA THYPI ON 2021 Purba, Novandi Putri, Nabila Benalu coffea leaf (Loranthus ferrugineus Roxb), Flavonoid, Titer Antibodi. The research in this paper aims to determine the effectiveness of immunostimulants from ethanol extract of coffee parasite leaves (Loranthus ferrugineus Roxb) with four variants of doses of 50mg / kgBB, 100mg / kgBB, 200mg / kgBB, 400mg / kgBB. This study used 18 male white rats with 200 gram BB which were divided into 6 treatment groups. Rats were injected with 0.1ml SDMS 1% for 7 consecutive days intraperitoneal, then on the 7th day each blood sample was taken through veins in the tail, CMC Na 0.5% suspension, and Levamisole suspension 50mg / kgBB as a positive control was administered orally on the 8th day. Then blood samples were collected in a micro tube and then 1900rpm was centrifuged at a temperature of 4oC for 10 minutes. The results of the study of ethanol extract of coffee parasite leaves proved effective as immunostimulants because they have a value close to positive control, starting from a dose of 200mg / kgBB to 400mg / kgBB. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2022-04-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/1009 10.35451/jfm.v4i2.1009 JURNAL FARMASIMED (JFM); Vol. 4 No. 2 (2022): Jurnal Farmasimed (JFM); 44-50 Jurnal FARMASIMED (JFM); Vol 4 No 2 (2022): Jurnal Farmasimed (JFM); 44-50 2655-0814 10.35451/jfm.v4i2 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/1009/529 Copyright (c) 2022 Novandi Purba, Nabila Putri

oai:ejournal.medistra.ac.id:article/1010 2023-11-23T04:16:49Z JFM:YRS

EVALUATION OF TITER RESULTS ON WIDAL EXAMINATION BASED ON THE DURATION OF FEVER IN HOSPITAL GRANDMED LUBUK PAKAM Rahayu, Asvia Krisdianilo, Visensius Hutabarat, Sintya Siregar, S'aadah Rizky, Vincentia Ade Demam Tipoid, Tes widal, Salmonella typhi Kultur merupakan salah satu metode yang digunakan untuk diagnosis demam tifoid, namun di beberapa daerah seringkali tidak ada fasilitas untuk kultur, maka cara lain untuk membantu menegakkan diagnosis yang praktis dan tersedia di rumah sakit adalah dengan tes Widal. Tujuan penelitian ini adalah untuk mengetahui evaluasi hasil titer pada pemeriksaan Widal berdasarkan lama demam di RS GrandMed Lubuk Pakam. Penelitian ini dilakukan di Laboratorium Patologi Klinik RS GrandMed Lubuk Pakam. Jenis penelitian ini adalah deskriptif yang dilaksanakan mulai bulan Mei 2021 sampai dengan Juni 2021. Jumlah sampel yang diperoleh sebanyak 25 orang. Dari 25 sampel tersebut, hasil uji Widal dengan titer antibodi terhadap antigen O 1:80 adalah 2 orang, 1:160 orang, 1:320 orang, 2 orang. Titer antibodi terhadap antigen H 1:80 sebanyak 2 orang, 1:160 sebanyak 4 orang, 1:320 sebanyak 2 orang, dan titer antibodi terhadap antigen AH 1:80 sebanyak 6 orang, 1:160 sebanyak 5 orang dan 1:320 sebanyak 1 orang. Kesimpulan dari penelitian ini adalah 1:160 merupakan titer paling banyak ditemukan dengan titer antibodi tertinggi terhadap antigen H yaitu 1:320 lebih sering ditemukan pada durasi demam dengan kisaran 6-9 hari sedangkan titer antibodi tertinggi terhadap antigen AH adalah 1:320 ditemukan selama penelitian. demam dengan kisaran 6-9 hari. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2022-04-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/1010 10.35451/jfm.v4i2.1010 JURNAL FARMASIMED (JFM); Vol. 4 No. 2 (2022): Jurnal Farmasimed (JFM); 51-58 Jurnal FARMASIMED (JFM); Vol 4 No 2 (2022): Jurnal Farmasimed (JFM); 51-58 2655-0814 10.35451/jfm.v4i2 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/1010/530 Copyright (c) 2022 Asvia Rahayu, Visensius Krisdianilo, Sintya Hutabarat

oai:ejournal.medistra.ac.id:article/1012 2023-11-23T04:16:49Z JFM:YRS

ANTIBACTERIAL ACTIVITY OF KERSEN LEAF EXTRACT (MUNTINGIA CALABURA L) AGAINST STAPHYLOCOCCUS AUREUS Kartika, Dewi Marbun, Romauli Anna Teresia Dewi, Ayu Puspita Muntingia calabura, Staphylococcus aureus, Zone of inhibition Kersen (Muntingia calabura) is a shady plant that is usually used as a shade. Cherry leaves contain several secondary metabolites such as flavonoid, tannin and terpenoid. Flavonoid can inhibit bacterial growth by denaturing proteins and damaging cell membranes and dissolving fats contained in cell walls. According to the World Health Organization as many as 25 million deaths worldwide in 2011, one third were caused by infectious diseases. One of the most common infectious diseases caused by the bacterium Staphyloccus aureus. The purpose of this study was to see whether the 96% ethanol extract of cherry leaves had antibacterial activity against Staphylococcus aureus. The concentration of the extract used was 15%, 30%, 45% and 60%. From the test results, it can be concluded that the largest inhibition zone diameter is at a concentration of 60% with an inhibition zone diameter of 6.78 mm and the smallest at a concentration of 30%, which is 0.42 mm. Concentration of 45% has (weak) activity inhibiting bacterial growth with an inhibition zone of 2.13 mm, while at a concentration of 15% it has no activity in the inhibition zone of bacterial growth. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2022-04-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/1012 10.35451/jfm.v4i2.1012 JURNAL FARMASIMED (JFM); Vol. 4 No. 2 (2022): Jurnal Farmasimed (JFM); 59-63 Jurnal FARMASIMED (JFM); Vol 4 No 2 (2022): Jurnal Farmasimed (JFM); 59-63 2655-0814 10.35451/jfm.v4i2 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/1012/528 Copyright (c) 2022 Dewi Kartika, Romauli Anna Teresia Marbun, Ayu Puspita Dewi

oai:ejournal.medistra.ac.id:article/1015 2023-11-23T04:16:49Z JFM:YRS

FORMULATION OF RED SPINNING LEAVES (AMARANTHUS) TRICOLOR L. AS NATURAL DYES IN PREPARATIONS EYESHADOW COMPACT POWDER Cahya, Cucu Arum Dwi Silalahi, Mega Sediaan daun bayam merah ekstrak eye shadow compact powder Berbagai jenis kosmetik yang sering kali diminati bagi para wanita yaitu eye shadow. Pada sebagian produk eye shadow masih terdapat penyalahgunaan pewarna tekstil yang berbahaya jika digunakan bagi tubuh. Daun bayam merah (Amaranthus tricolor L.) mempunyai pigmen betasianin yang dapat dijadikan pewarna alami pada sediaan eye shadow compact powder. Penelitian ini bertujuan untuk membuat sediaan eye shadow compact powder dengan menggunakan ekstrak daun bayam merah sebagai pewarna alami serta memenuhi persyaratan mutu fisik dan tidak mengiritasi kulit.Daun bayam merah segar dilakukan ekstraksi dengan metode maserasi dengan menggunakan pelarut etanol 70% dan ditambahkan asam sitrat, kemudian pelarut diuapkan dengan bantuan alat rotary evaporator pada suhu 50°C, kemudian dipekatkan dengan waterbath (penangas air) pada suhu 78°C sampai didapatkan ekstrak kental. Kemudian diformulasikan ke dalam bentuk sediaan eye shadow compact powder dengan menggunakan kaolin, zink stearat, nipagin, isopropyl miristat, lanolin, oleum rosae, dan talkum. Dengan variasi konsentrasi ekstrak daun bayam merah F0 (Blanko), F1 (8%), F2 (12%)  dan F3 (18%). Kemudian campuran serbuk dicetak dengan alat press. Selanjutnya dilakukan pemeriksaan persyaratan mutu fisik sediaan eye shadow compact powder yaitu uji dispersi warna (homogenitas), uji poles, uji kerapuhan, dan uji stabilitas terhadap bentuk,warna dan aroma pada penyimpanan suhu kamar selam 30 hari, serta uji iritasi terhadap sediaan F0 (Blanko), F1 (8%), F2 (12%)  dan F3 (18%). Berdasarkan hasil yang diperoleh semua sediaan F0 (Blanko), F1 (8%), F2 (12%) dan F3 (18%) homogen terdispersi merata, tidak rapuh, stabil dalam penyimpanan suhu kamar selama 30 hari, dan tidak mengiritasi kulit. Namun pada pemeriksaan uji oles pada sediaan F3 (18%) memiliki daya oles yang kurang baik dikarenakan perlu 5 kali pengolesan agar warna terlihat jelas menempel pada kulit sedangkan pada sediaan F0 (Blanko), F1 (8%) dan F2 (12%)  cukup dengan 3 kali pengolesan warna sudah terlihat dan menempel. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2022-04-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/1015 10.35451/jfm.v4i2.1015 JURNAL FARMASIMED (JFM); Vol. 4 No. 2 (2022): Jurnal Farmasimed (JFM); 72-79 Jurnal FARMASIMED (JFM); Vol 4 No 2 (2022): Jurnal Farmasimed (JFM); 72-79 2655-0814 10.35451/jfm.v4i2 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/1015/532 Copyright (c) 2022 Cucu Arum Dwi Cahya, Mega Silalahi

oai:ejournal.medistra.ac.id:article/1016 2023-11-23T04:16:49Z JFM:YRS

ANTI-BACTERIAL ACTIVITY TESTING OF ETHANOL EXTRACT 96% PAINAGE SKIN (ANANAS COMOSUS (L.) MERR) AGAINST ESCHERICHIA COLI BACTERIA) . S, Aminah Abdilantri, Dewi Antibacteria, Pineapple peelextract, Escherichia coli Pineapple peel (Ananas comosus (L.) Merr) is waste form the pineapple fruit. The purpose of this study was to determine the content of pineapple peel extract and to antibacterial activity in various concentrations effective in inhibiting the growth of Escherichia coli. Escherichia coli is a bacterium that generally lives in the large intestine of humans can become a pathogen when it reaches tissues outside the digestive tract which can cause diarrheal disease. The pineapple peel extract is made by using the ectraction method in the form of meceration. The method used in the inhibitory test using the two replication sampels in each treatment groups. The samples consisted of 6 treatment groups is pineapple peel extract concentration 25mg/ml, 50mg/ml, 75mg/ml, and 100mg/ml, as well as positive and negative control. The results obtained from pineapple screening contain alkaloi, flavonoid, tanin, and saponin compounds. The data analysis showsthat pineanepple peel extract concentrations of 25mg/ml, 50mg/ml, 75mg/ml, and 100mg/ml had inhibitory sones with the medium-strong category while ciproloxacin as the control has a strong inhibition zone. The conclusion that while the extract concentration increases, the diameter of the inhibition zone increases. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2022-04-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/1016 10.35451/jfm.v4i2.1016 JURNAL FARMASIMED (JFM); Vol. 4 No. 2 (2022): Jurnal Farmasimed (JFM); 64-71 Jurnal FARMASIMED (JFM); Vol 4 No 2 (2022): Jurnal Farmasimed (JFM); 64-71 2655-0814 10.35451/jfm.v4i2 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/1016/531 Copyright (c) 2022 Aminah . S, Dewi Abdilantri

oai:ejournal.medistra.ac.id:article/1018 2023-11-23T04:16:49Z JFM:YRS

FORMULATION OF SOLID BATH SOAP PREPARATIONS OF PURPLE SWEET POTATO ETHANOL EXTRACT (IPOMEA BATATAS L) AS A SKIN MOISTURIZER Wulandari, Suci Niasari Silaen, Ayu Renta Wahyuni, Siti Purple sweet potato (Ipomoea batatas L), solid soap, moisturize Soap is a surfatctant used to clean or wash something that is available in solid and liquid form. Soap can be useful as a cleaning tool, this is because soap molecules contain polar (bonded with water) and non-polar (bonded with oil) groups so that they can clean grease or dirt that is not lifted by water. Soap is made by applying a saphonification reaction using olive oil, NaOH, and purple sweet potato extract as the basic ingredients. The addition of NaOH concentration an affect the weight of the soap produced. Purple sweet potato is a sweet potato that has natural dyes a anthocyanins that function as antioxidant. The purpose of this study was to obtain a solid bath soap formulation with purple sweet potato extract. Furthermore, purple sweet potato extract was formulated based on formula with concentration difference of 3,5%, 4,5%, 5,5%. Furthermore, preparations have been made with organoleptic tests, pH tests, and foam stability tests. It can be concluded that purple sweet potato extract can be used as a solid soap preparation and there is a concentration effect on the organoleptic test soap quality, pH, foam stability and moisture content. The preparation of solid bath soap from purple sweet potato ethanol extract has the ability to moisturize the skin, and the highest concentration obtained at a concentration of 5,5% with 57,83% moisture can moisturize the skin and at concentration of 4,5% with 48,3% humidity as well. Can moisturize the skin but with a moderate level of humidity, and at a concentration of 3,3% with 43,00% humidity with a lower humidity level. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2022-04-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/1018 10.35451/jfm.v4i2.1018 JURNAL FARMASIMED (JFM); Vol. 4 No. 2 (2022): Jurnal Farmasimed (JFM); 80-84 Jurnal FARMASIMED (JFM); Vol 4 No 2 (2022): Jurnal Farmasimed (JFM); 80-84 2655-0814 10.35451/jfm.v4i2 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/1018/533 Copyright (c) 2022 Suci Wulandari, Ayu Renta Niasari Silaen, Siti Wahyuni

oai:ejournal.medistra.ac.id:article/1022 2023-11-23T04:16:49Z JFM:YRS

ANTIBACTERIAL ACTIVITY TEST OF ETHANOL EXTRACT OF MANILA SAWO LEAVES (MANILKARA ZAPOTA) AGAINST BACTERIA STREPTOCOCCUS MUTANS) Turnip, Nur Ulina M. Br. Sirait, Nia Yoseva ., Sunariati Uji aktivitas daun sawo manila antibakteri Streptococcus mutans Daun sawo manila merupakan salah satu tanaman yang dapat digunakan sebagai obat tradisional. Daun sawo manila mengandung senyawa metabolit sekunder flavonoid, fenolik, tanin, saponin, yang bersifat sebagai antibakteri. Tujuan penelitian ini adalah untuk mengetahui aktivitas antibakteri pada ekstrak daun sawo manila (Manilkara zapota) terhadap bakteri Streptoccocus mutans. Penelitian ini merupakan penelitian eksperimental laboratorium. Sampel yang digunakan diperoleh dari daun sawo diekstraksi dengan metode maserasi menggunakan pelarut etanol. Metode yang digunakan dalam uji daya hambat antibakteri menggunakan difusi cakram dengan 6 kelompok perlakuan yang terdiri dari konsentrasi 50%, 60%, 70%, 80%, serta Amoxicillin sebagai kontrol positif dan DMSO sebagai kontrol negatif diulang sebanyak 4 kali pengulangan. Parameter yang diamati adalah diameter zona hambat pertumbuhan bakteri Streptococcus mutans. Analisis data menggunakan One way-ANOVA. Hasil penelitian menunjukkan ekstrak etanol daun sawo manila memiliki kemampuan daya hambat antibakteri pada konsentrasi 50% (15,85 mm), 60% (16,45 mm), 70% (17,05 mm), 80% (17,45 mm). Kesimpulan dari penelitian ini membuktikan bahwa ekstrak etanol daun sawo manila memiliki aktivitas daya hambat antibakteri terhadap bakteri Streptococcus mutans. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2022-04-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/1022 10.35451/jfm.v4i2.1022 JURNAL FARMASIMED (JFM); Vol. 4 No. 2 (2022): Jurnal Farmasimed (JFM); 85-91 Jurnal FARMASIMED (JFM); Vol 4 No 2 (2022): Jurnal Farmasimed (JFM); 85-91 2655-0814 10.35451/jfm.v4i2 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/1022/535 Copyright (c) 2022 Nur Ulina M. Br. Turnip, Nia Yoseva Sirait, Sunariati .

oai:ejournal.medistra.ac.id:article/1024 2023-11-23T04:16:49Z JFM:YRS

TESTING THE EFFECTIVENESS OF FORMULATION OF ANTIFUNCIAL PREPARATION OF GARLIC (ALLIUM SATIVUM L.) ETHANOL EXTRACT MOUNTWASH ON THE GROWTH OF CANDIDA ALBICANS Pranata, Chandra Sundara, Putri ., Evi Mouthwash Allium sativum L agar diffusion Candida albicans Telah dilakukan penelitian tentang uji efektivitas formulasi sediaan antifungi obat kumur ekstrak etanol bawang putih (Allium sativum L.) Terhadap pertumbuhan jamur Candida albicans. Ekstrak  etanol bawang putih mengandung beberapa senyawa metabolit sekunder, dimana yang berperan sebagai antijamur adalah alkaloid, flavonoid, saponin, dan tanin. Obat kumur ekstrak etanol bawang putih dibuat menjadi lima formula yaitu F0 (basis), F1 (ekstrak etanol bawang putih 15%), F2 (ekstrak etanol bawang putih 25%), F3 (ekstrak etanol bawang putih 50%), dan F4 (ekstrak etanol bawang putih 100%). Evaluasi obat kumur meliputi pemeriksaan Organoleptis, dan Homogenitas. Uji aktivitas antijamur sediaan obat kumur dilakukan dengan metode difusi agar dan dianalisis menggunakan ANOVA satu arah. Hasil evaluasi menunjukkan bahwa sifat fisik sediaan obat kumur memberikan hasil yang baik dan memenuhi syarat sediaan obat kumur. Hasil uji aktivitas antijamur sediaan obat kumur memberikan diameter rata-rata daya hambat sebesar F1 (12,3 mm), F2 (17,3 mm), F3 (18,5 mm) dan F4 (21,6 mm). Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2022-04-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/1024 10.35451/jfm.v4i2.1024 JURNAL FARMASIMED (JFM); Vol. 4 No. 2 (2022): Jurnal Farmasimed (JFM); 92-97 Jurnal FARMASIMED (JFM); Vol 4 No 2 (2022): Jurnal Farmasimed (JFM); 92-97 2655-0814 10.35451/jfm.v4i2 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/1024/536 Copyright (c) 2022 Chandra Pranata, Putri Sundara, Evi .

oai:ejournal.medistra.ac.id:article/1061 2023-11-23T04:16:49Z JFM:YRS

ANTIFUNGAL EFFECTIVENESS OF LEAF ETHANOL EXTRACT WAKE UP (COLEUS AMBOINICUS)AGAINST THE FUNGI CANDIDA ALBICANS Situmorang, Novidawati Boru Bangun-bangun, Antijamur, Candida albicanss Daun bangun-bangun (Coleus amboinicus), merupakan Salah satu tumbuhan yang berpotensi sebagai obat dan telah sering digunakan oleh masyarakat. Kandungan senyawa Flavonoid dalam daun Bangun-bangun diyakini memiliki manfaat dan berpotensi sebagai antijamur terhadap Candida albicans. Selain itu adanya resistensi akan obat kimiawi sehingga pengobatan yang bersumber dari alam mulai dikembangkan. Tujuan dari penelitian ini yaitu untuk mengetahui aktivitas antijamur ekstrak etanol daun Bangun-bangun (Coleus amboinicus) terhadap bakteri Candida albicanss. Penelitian diawali dengan melakukan pemeriksaan metabolit alkaloid, saponin, flavanoid, tanin dan kemudian pengujian aktivitas antijamur terhadap Candida albicans dengan beberapa konsentrasi yaitu 5, 10, dan 15%, metode difusi agar kertas cakram. Hasil skrining fitokimia daun Bangun-bangun menunjukkan adanya alkaloid, tanin, flavonoid, dan saponin. Hasil pemeriksaan karakteristik serbuk simplisia daun bangun-bangun didapat kadar air 9,27%, kadar sari larut air 14,5%, kadar sari larut etanol 9,76%, sesuai dengan materia medika indonesia. Hasil skrining fitokimia yang didapat yaitu fenolik, flavonoid, saponin, steroid/triterpenoid. Pengujian aktivitas antijamur ekstrak etanol daun bangun-bangun menunjukkan diameter zona hambat pada konsentrasi 5%, 10%, 15%, adalah 14,47 mm, 15,46 mm, 16,34 mm. Maka dapat disimpulkan bahwa semakin tmeningkat konstrasi ekstrak,makasemakin besar diameter zonahambatnya. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2022-04-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/1061 10.35451/jfm.v4i2.1061 JURNAL FARMASIMED (JFM); Vol. 4 No. 2 (2022): Jurnal Farmasimed (JFM); 98-102 Jurnal FARMASIMED (JFM); Vol 4 No 2 (2022): Jurnal Farmasimed (JFM); 98-102 2655-0814 10.35451/jfm.v4i2 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/1061/537 Copyright (c) 2022 Novidawati Boru Situmorang

oai:ejournal.medistra.ac.id:article/1067 2023-11-23T04:16:49Z JFM:YRS

ANTIBACTERIAL ACTIVITY OF ETHANOL EXTRACT PACAR AIR LEAVES (IMPATIENS BALSAMINA L.) AGAINST PROPIONIBACTERIUM ACNE Octora, Debi Dinha Waruwu, Krismawati Kata kunci: Antibakteri, Ekstrak Etanol Daun pacar air, P. acnes Keywords: Antibacterial, Ethanol Extract of Pacar air Leaves, P. acnes ABSTRAK Aktivitas antibakteri Impatiens balsamina L. telah dipelajari selama bertahun-tahun. Daun inai air mengandung flavonoid, saponin dan tanin yang memiliki kemampuan untuk menghambat pertumbuhan bakteri. P. acnes merupakan salah satu jenis bakteri yang dapat menyebabkan infeksi pada jerawat. Salah satu tujuan penelitian ini adalah untuk mengetahui aktivitas antibakteri ekstrak etanol daun inai air dan konsentrasi yang paling efektif dalam menghambat bakteri P. acnes. Penelitian ini merupakan penelitian eksperimen murni. Daun inai air dimaserasi dengan pelarut etanol 96%. Uji aktivitas antibakteri dilakukan dengan metode difusi cakram. Penelitian dilakukan dengan 3 variasi konsentrasi yang berbeda. Hasil penelitian menunjukkan adanya aktivitas antibakteri pada setiap konsentrasi. Kesimpulannya ekstrak etanol daun inai dengan konsentrasi 25%, 50% dan 75% memberikan penghambatan pertumbuhan bakteri paling efektif dengan konsentrasi 25%, 50% dan 75% yang termasuk dalam kategori kuat. Saran diharapkan bagi peneliti selanjutnya untuk dapat menguji bakteri lain dan membuat formulasi dari ekstrak daun inai air. ABSTRACT The antibacterial activity of Impatiens balsamina L. has been studied for many years. Water henna leaves contain flavonoids, saponins and tannins which have the ability to inhibit bacterial growth. P. acnes is one type of bacteria that can cause infection in acne. One of the objectives of this study was to determine the antibacterial activity of the ethanol extract of henna water leaves and the most effective concentration in inhibiting P. acnes bacteria. This research is a pure experimental research. Water henna leaves were macerated with 96% ethanol as solvent. Antibacterial activity test was carried out by disc diffusion method. The research was conducted with 3 different concentration variations. The results showed that there was antibacterial activity at each concentration. The conclusion is that the ethanol extract of henna leaves with concentrations of 25%, 50% and 75% gave the most effective bacterial growth inhibition with concentrations of 25%, 50% and 75% which were included in the strong category. Suggestions are expected for further researchers to be able to test other bacteria and make formulations from water henna leaf extract.   Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2022-04-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/1067 10.35451/jfm.v4i2.1067 JURNAL FARMASIMED (JFM); Vol. 4 No. 2 (2022): Jurnal Farmasimed (JFM); 103-109 Jurnal FARMASIMED (JFM); Vol 4 No 2 (2022): Jurnal Farmasimed (JFM); 103-109 2655-0814 10.35451/jfm.v4i2 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/1067/538 Copyright (c) 2022 Debi Dinha Octora, Krismawati Waruwu

oai:ejournal.medistra.ac.id:article/1082 2023-11-23T04:16:49Z JFM:YRS

TEST THE ANTIBACTERIAL ACTIVITY OF ETHANOL EXTRACT OF CRASSOCEPHALUM CREPIDIOIDES LEAF AGAINST STREPTOCOCCUS PYOGENES anggraeni, Ratih Lingga, Nola Monalisa antibacterial, Crassocephalum crepidioides, Streptococcus pyogenes The ethanol extract of Crassocephalum crepidioides leaves was tested against Streptococcus pyogenes bacteria. Extracts from the leaves of Crassocephalum crepidioides are known to have the potential to suppress microbial growth because contain active compounds of alkaloids and flavonoids. The test was carried out by the diffusion method using disc paper that had been soaked in a solution of ethanol extract of Crassocephalum crepidioides leaves with a concentration of 20%, 30%, 40%, 50%. Amoxicillin as a positive control and DMSO as a negative control. It is known that the inhibition of bacterial growth at a concentration of 20% the inhibition zone is 11mm, the concentration of the inhibition zone of 30% is 11.8mm, the concentration of 40% of the inhibition zone is 12.2mm, the concentration of 50% is the inhibition zone is 12.6mm. The higher the concentration of the ethanol extract of Crassocephalum crepidioides leaves, the wider the area of inhibition against Streptococcus pyogenes bacteria. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2022-04-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/1082 10.35451/jfm.v4i2.1082 JURNAL FARMASIMED (JFM); Vol. 4 No. 2 (2022): Jurnal Farmasimed (JFM); 121-126 Jurnal FARMASIMED (JFM); Vol 4 No 2 (2022): Jurnal Farmasimed (JFM); 121-126 2655-0814 10.35451/jfm.v4i2 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/1082/547 Copyright (c) 2022 Ratih anggraeni, Nola Monalisa Lingga

oai:ejournal.medistra.ac.id:article/1084 2023-11-23T04:16:49Z JFM:YRS

HAND AND BODY LOTION FORMULATION OF AVOVO SKIN EXTRACT (PERSEA FREESIMA GAERTN) AS A MOISTURIZER Rani, Yosi Darmi Delima, Cici Avocado, Antioxidant, Ethanol 96% Avocados have been used by the community for generations as traditional medicinal ingredients. Avocado (Persea Americana Mill) is a plant that contains many compounds that are antioxidants. Flavonoids and tannins are compounds that have antioxidant activity which are suspected as sunscreens. Research Objectives To determine the concentration of avocado skin extract (Persea Gratissima Gaertn) 3%, 5%, 7% as hand and body lotion. Laboratory experimental research. Based on the results of the one-way ANOVA test that was used to analyze the avocado peel extract as skin flexion at blank concentrations of 3% concentration, 5% concentration and 7% way concentration, the mean Squaer result was 0.333 with results 0.052 > 0.05. it can be said that the results of the table above indicate that avocado skin can be used as skin moisture. Conclusion Based on the results of community tests conducted by the three hand and body lotion formulas, avocado skin extract that has been stored for 28 days of storage shows that the skin of the fruit can be used as moisture skin. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2022-04-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/1084 10.35451/jfm.v4i2.1084 JURNAL FARMASIMED (JFM); Vol. 4 No. 2 (2022): Jurnal Farmasimed (JFM); 110-115 Jurnal FARMASIMED (JFM); Vol 4 No 2 (2022): Jurnal Farmasimed (JFM); 110-115 2655-0814 10.35451/jfm.v4i2 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/1084/539 Copyright (c) 2022 Yosi Darmi Rani, Cici Delima

oai:ejournal.medistra.ac.id:article/1088 2023-11-23T04:16:49Z JFM:YRS

MANUFACTURED OF LOTION FROM AVOCADO LEAF ETHANOL EXTRACT ( PERSEA AMERICANA MILL) AS SKIN MOISTURIZER Br Manik, Margaretta Olivia Mahmiara, Nopri Avocado Leaf Extrach Skin Moisture Skin Moisturizing Lotion Abstrak Alpukat diformulasikan menjadi lotion, berdasarkan penelitian sebelumnya daun nya mengandung antioksidan tinggi yang diwakili dengan senyawa flavonoid. Tujuannya untuk mengetahui sediaan dari ekstrak etanol daun alpukat dapat melembabkan kulit.          Penelitian ini dengan metode eksperimen. Ekstrak daun alpukat dilakukan dengan proses maserasi. Pemeriksaan sediaan dilakukan pada penelitian ini adalah uji skrining fitokimia, uji Ph, uji iritasi dan uji kelembapan kulit dengan konsentrasi 3% dan 5%.   Abstract Avocado is formulated into a lotion, based on previous research, its leaves contain high antioxidants which are represented by flavonoid coumpounds . The aim was to determine whether the preparation of avocado leaf ethanol extract could moisturerize the skin. This research uses the experimental method. Leaf was carried out by a maceration process. Examination of the preparation carried out in this study were phytochemical screening tests, pH, Irritation and skin moisture with concentration of 3% and 5%. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2022-04-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/1088 10.35451/jfm.v4i2.1088 JURNAL FARMASIMED (JFM); Vol. 4 No. 2 (2022): Jurnal Farmasimed (JFM); 116-120 Jurnal FARMASIMED (JFM); Vol 4 No 2 (2022): Jurnal Farmasimed (JFM); 116-120 2655-0814 10.35451/jfm.v4i2 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/1088/540 Copyright (c) 2022 Margaretta Olivia Br Manik, Nopri Mahmiara

oai:ejournal.medistra.ac.id:article/1111 2023-11-23T04:16:15Z JFM:YRS

EFFECT OF PROCESSING VARIOUS TYPES OF RICE ON CARBOHYDRATE LEVELS Pranata, Chandra Silalahi, Jansen ., Yuandani Cintya, H Karbohidrat Pengolahan Beras Beras adalah salah satu makanan pokok di Indonesia yang mempunyai kandungan karbohidrat yang cukup tinggi antara 70 – 80 %. Zaman sekarang ada berapa cara untuk mengelolah beras menjadi nasi yakni dengan cara kukus dan menggunakan ricecooker. Tujuan dari penelitian ini adalah untuk menetukan kadar karbohidrat pada beras putih, beras merah dan beras hitam sebelum dan sesudah mengalami pengolahan menggunakan metode luff schrool. Berdasarkan hasil pemeriksaan karbohidrat dari beras putih, beras merah dan beras hitam sebelum dan sesudah mengalami pengolahan maka didapatkan hasil pemeriksaan sebelum mengalami pengolahan kadar karbohidrat tertinggi adalah pada beras putih 52,56 ± 0,20 % dan terendah beras hitam 40,47 ± 0,20 %, sedangkan jika dilihat dari cara pengolahan untuk kadar karbohidrat terendah terdapat pada beras hitam kukus dengan kadar 6,00± 0,20% sementara tertinggi pada beras putih ricecooker 14,00 ±1,4 % sehingga didapatkan kesimpulan bahwa adanya pengaruh pengolahan dalam penurunan kadar karbohidrat dalam beras. Kata Kunci: Karbohidrat, Pengolahan, Beras Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2022-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/1111 10.35451/jfm.v5i1.1111 JURNAL FARMASIMED (JFM); Vol. 5 No. 1 (2022): Jurnal Farmasimed (JFM); 1-4 Jurnal FARMASIMED (JFM); Vol 5 No 1 (2022): Jurnal Farmasimed (JFM); 1-4 2655-0814 10.35451/jfm.v5i1 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/1111/654 Copyright (c) 2022 Chandra Pranata, Jansen Silalahi, Yuandani ., H Cintya

oai:ejournal.medistra.ac.id:article/1193 2024-03-18T00:56:33Z JFM:YRS

MORINGA LEAF (Moringa Oleifera L.) ETHANOL EXTRACT CLAY MASK FORMULATION AS ANTI-AGING Nurussakinah, Nurussakinah Fhitriana, Suzan Khairani, Tetty Noverita Utari, Sri Clay masker moringa leaves anti-aging Aging is a human physical change caused by age, psychological, and social factors, especially on the face, neck, upper arms and hands. Aging is unavoidable and goes at different speeds, depending on one's genetics, environment and lifestyle. Synthetic antiocxidant products are many circulated in the market which have a negative impact on health. However Antioxidant compound are widely spread in nature expecially in plant. Moringa leaf  is one of plants that contain abundant antioxidant, alkaloids, flavonoids, phenolics, triterpenoids/steroids and tannins. Many of people Switch to natural products. Mask from natural products are not causing irritation or less side effects. clay face mask are mostly used because of their skin rejuvenating abilities. Purpose: To know either Moringa leaf ethanol extract can be formulated in clay mask preparations and the optimal effect is to prevent aging or not. Methods: the research is including how to make clay mask with ethanol extract of Moringa leaves at concentrations of 6%, 8% and 10%. The evaluation of the physical quality of the preparation, testing the effectiveness of clay masks with ethanol extract of Moringa leaves as anti-aging. Result: the preparation is qualify the characteristic test, had a pH of 4.9-5.2, a drying time of 15-23.5 minutes, an o/w emulsion type, was stable for 12 weeks of storage, and was not caused irritation. The best result of anti-aging effectiveness test was at a concentration of 10% with 36.25 moisture content, 23.25 fineness content, 33.75 pores, 20.5 blemishes and 15.5 wrinkles. Conclusion: Moringa leaf ethanol extract can be formulated in clay mask , and is able to give the best anti-aging effect at 10% formula. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2023-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/1193 10.35451/jfm.v6i1.1193 JURNAL FARMASIMED (JFM); Vol. 6 No. 1 (2023): Jurnal Farmasimed (JFM); 1-8 Jurnal FARMASIMED (JFM); Vol 6 No 1 (2023): Jurnal Farmasimed (JFM); 1-8 2655-0814 10.35451/jfm.v6i1 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/1193/881 Copyright (c) 2023 Nurussakinah Nurussakinah, SUZAN FHITRIANA, TETTY NOVERITA KHAIRANI, SRI UTARI https://creativecommons.org/licenses/by/4.0/

oai:ejournal.medistra.ac.id:article/1228 2022-11-02T15:03:03Z JFM:YRS

oai:ejournal.medistra.ac.id:article/1233 2024-09-09T07:43:28Z JFM:YRS

ANTI-INFLAMMATORY ACTIVITY TEST OF LIME LEAF (CITRUS AURANTIIFOLIA) ETHANOL EXTRACT IN MALE MICE (MUS MUSCULUS) INDUCED CARRAGEENAN ON 2022 Purba, Novandi Andriani Harianja, Bulan Akbar, Khairil Harefa, Karnirius Daun Jeruk Nipis (Citrus aurantiifolia), Antiinflamasi Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak etanol daun jeruk nipis (Citrus aurantiifolia) sebagai antiinflamasi. Metode yang digunakan adalah udema buatan telapak kaki mencit putih jantan dengan induksi karagenan 1%. Pengujian aktivitas antiinflamasi ekstrak etanol daun jeruk nipis menggunakan 25 hewan uji, dengan 5 kelompok perlakuan. Kelompok terdiri atas kontrol positif yang diberikan na.diklofenak dengan dosis 6,5 mg/kgBB, kontrol negatif yang diberi perlakuan CMC Na 0,5%, dan 3 kelompok ekstrak yang dimana kelopok ektrak dosis 100 mg/kgBB, kelompok ekstrak dosis 200 mg/kgBB, dan kelompok ekstrak dosis 300 mg/kgBB. persen radang pada kelima kelompok uji mengalami penurunan secara terus menerus mulai dari menit ke-60 sampai menit ke-360 setelah induksi karagenan. persen radang terbesar terjadi pada menit ke-120 pada suspensi Na.cmc dan diikuti oleh 100 mg/kgBB, 200 mg/kgBB, 300 mg/kgBB dan Na.diklofenak. nilai persen inhibisi radang terbesar dimiliki oleh kelompok Na.diklofenak dan diikuti oleh 300 mg/kgBB, 200 mg/kgBB dan 100 mg/kgBB. Hal ini berarti, persen hambatan yang baik terdapat pada EEDJN 300 mg/kgBB setelah Na.diklofenak, kemudian diikuti EEDJN 200 dan 100 mg/kgBB dan hal ini menunjukan bahwa kelompok Na.diklofenak, 100, 200 dan 300 mg/kgBB memiliki potensi sebagai agen antiinflamasi sedangkan kelompok Na.Cmc tidak. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2022-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/1233 10.35451/jfm.v5i1.1233 JURNAL FARMASIMED (JFM); Vol. 5 No. 1 (2022): Jurnal Farmasimed (JFM); 14-21 Jurnal FARMASIMED (JFM); Vol 5 No 1 (2022): Jurnal Farmasimed (JFM); 14-21 2655-0814 10.35451/jfm.v5i1 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/1233/656 Copyright (c) 2022 Novandi Purba, Bulan Andriani Harianja, Khairil Akbar https://creativecommons.org/licenses/by-nd/4.0

oai:ejournal.medistra.ac.id:article/1238 2023-11-23T04:16:15Z JFM:YRS

ANALGESIC ACTIVITY TEST OF WARU (Hibiscus tiliaceus L.) LEAVES ETHANOL EXTRACT IN MALE WHITE MISCULES (Mus musculus) Situmorang, Novidawati Boru Widya Ningsih, Silvia Waru Leaf, Analgesic, Plantar test infra test Herbal remedies in therapy have been used in the treatment of pain since time immemorial. Pain is a sensory and emotional event that causes discomfort due to tissue damage. Most of the analgesics used in modern medicine have side effects on either the gastro-intestinal tract or the nervous system. Empirically waru leaves have been used as traditional medicine. The purpose of this study was to evaluate the analgesic effect of the ethanol extract of waru leaf and compare it with mefenamic acid tablets and then measured by the plantar test infra red (IR) 96 nm. Twenty five mice were divided into five groups. Three of them were treated with ethanol extract of waru leaves with doses of 100, 200, 300 mg/kgbw, 0.5% Na-CMC (negative control), and 500 mg Mefenamic Acid tablets (positive control). Infrared pain induction was performed every 10 minutes for 60 minutes. The maximum analgesic activity was indicated by a dose of 300 mg/kg body weight extract at 60 minutes which was 23.8 where the effectiveness was almost the same as the standard drug Mefenamic Acid, which was 24.3 while the dose of 200 mg/kgBB was 20.9 and 100 mg/kgBW was 19.9. The data obtained were then processed using one way ANOVA. The conclusion of the study revealed that hibiscus leaf (Hibiscus tiliaceus L.) has significant analgesic properties, especially in higher doses Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2022-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/1238 10.35451/jfm.v5i1.1238 JURNAL FARMASIMED (JFM); Vol. 5 No. 1 (2022): Jurnal Farmasimed (JFM); 22-25 Jurnal FARMASIMED (JFM); Vol 5 No 1 (2022): Jurnal Farmasimed (JFM); 22-25 2655-0814 10.35451/jfm.v5i1 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/1238/657 Copyright (c) 2022 Novidawati Boru Situmorang, Silvia Widya Ningsih

oai:ejournal.medistra.ac.id:article/1239 2023-11-23T04:16:15Z JFM:YRS

FORMULATION OF BLUE POWDER BLOOD SAMBANG LEAF EXTRACT(Excoecaria cochinchinensis) AS COLOR EXPERIENCE S, Aminah . Umairoh Br. Lubis, Rara Daun sambang darah (Excoecaria cochinchinensis), Pemerah pipi, formulasi, bentuk compact powder Blush on atau pewarna pipi adalah salah satu sediaan kosmetik yang digunakan untuk mewarnai pipi dengan sentuhan artistik sehingga dapat meningkatkan estetika dalam tata rias wajah. Pewarna pipi dapat digunakan langsung dengan melekatkan pada kulit pipi. Tujuan : penelitian ini dilakukan untuk mengetahui kestabilan formulasi dan untuk mengetahui adanya reaksi iritasi pada pembuatan sediaan pewarna pipi compact powder dengan menggunakan ekstrak daun sambang darah. Metode : Ekstrak diperoleh dengan cara maserasi menggunakan etanol 96% untuk ekstrak daun sambang darah (Excoecaria cochinchinensis) dengan konsentrasi 10%, 15%, 20%. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2022-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/1239 10.35451/jfm.v5i1.1239 JURNAL FARMASIMED (JFM); Vol. 5 No. 1 (2022): Jurnal Farmasimed (JFM); 26-30 Jurnal FARMASIMED (JFM); Vol 5 No 1 (2022): Jurnal Farmasimed (JFM); 26-30 2655-0814 10.35451/jfm.v5i1 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/1239/658 Copyright (c) 2022 Aminah . S, Rara Umairoh Br. Lubis

oai:ejournal.medistra.ac.id:article/1242 2023-11-23T04:16:15Z JFM:YRS

EFFECTIVENESS OF COMBINATION OF BITTER GOURD (Momordica charantia L.) AND GARLIC (Allium sativum L.) EXTRACT ON MALE WHITE MICE (Mus muscullus) AS APHRODISIAC Alfiraza, Ery Nourika Listina, Osie Gautama, Tomy Sugiarto Aphrodisiac bitter melon fruit garlic ethanol extract Aphrodisiac is a material that used to increase libido or sexual desire. The purpose of this study was to determine the effect of aphrodisiac on bitter melon fruit (Momordica charantia L.) and garlic (Allium sativum L.) in male white mice (Mus musculus L.) and at what concentration the combination of bitter melon and garlic had the best aphrodisiac effect. Bitter melon powder and garlic were macerated with 70% ethanol for 4 x 24 hours. In this study, ICC (Introduction, Climbing, Coitus) method was used in 25 male mice divided into 5 groups. Group I as negative control was given aquadest, group II was given a single dose of bitter melon, group III a single dose of garlic, Group IV, and Group V were given a combination of bitter melon extract and garlic with ½ combination 980 mg/kg body weight: 150mg /kg body weight, Group IV, and V were given a combination of bitter melon extract and garlic with 1 combination 1960 mg/kg body weight: 300 mg/kg body weight. Each group was given oral test materials, group I, II, III, IV, and V was given extracts according to the dose for 2 hours. Then those observed and calculated the number of Introduction, Climbing, and Coitus. The results showed that the combination of bitter melon extract and garlic group V (1960 mg/kg body weight: 300 mg/kg body weight) had the best aphrodisiac activity compared to other extract combination activities, and all extract combinations showed significantly different aphrodisiac effects. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2022-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/1242 10.35451/jfm.v5i1.1242 JURNAL FARMASIMED (JFM); Vol. 5 No. 1 (2022): Jurnal Farmasimed (JFM); 31-38 Jurnal FARMASIMED (JFM); Vol 5 No 1 (2022): Jurnal Farmasimed (JFM); 31-38 2655-0814 10.35451/jfm.v5i1 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/1242/659 Copyright (c) 2022 Ery Nourika Alfiraza, Osie Listina, Tomy Sugiarto Gautama

oai:ejournal.medistra.ac.id:article/1254 2023-11-23T04:16:15Z JFM:YRS

STABILITY TEST OF CLOVE FLOWER ESSENTIAL OIL OINTMENT (SYZIGIUM AROMATICUM L) WATER SOLUTION BASED IN PLASTIC AND GLASS PACKAGING Afriyani, Neti Susanti, Hari Sugihartini, Nining Salep basis larut air, uji stabilitas, minyak atsiri bunga cengkeh, Syzigium aromaticum Cengkeh (Syzygium aromaticum L) merupakan salah satu tanaman herbal yang sering digunakan masyarakat karena kandungan utama minyak atsiri bunga cengkeh (Syzigium aromaticum) yang utama adalah eugenol yang memiliki khasiat sebagai antiinflamasi. Formulasi salep telah dilakukan dengan membuat sediaan salep dalam basis larut air (PEG). Salah satu persyaratan sediaan salep adalah stabil. Penggunaannya secara tradisional memerlukan waktu penyiapan yang lama sehingga perlu formulasi sediaan yang lebih praktis dan stabil dalam penyimpanan. Tujuan penelitian ini untuk mengetahui stabilitas salep minyak atsiri bunga cengkeh (Syzigium aromaticum) dalam basis larut air (PEG) yang baik dan optimal. Minyak atsiri bunga cengkeh diformulasi dalam bentuk sediaan salep basis larut air dalam kemasan tube plastik dan gelas. Evaluasi dilakukan pada uji stabilitas sifat fisika meliputi organoleptik, viskositas, pH, sentrifuga, freezer thaw Uji stabilitas dilakukan penyimpanan pada Climatic chamber dengan kondisi suhu 40°C ± 2°C kelembaban 75% RH ± 5% selama 90 hari kemudian diuji pada hari ke-0, ke-7, ke-14, ke-30, ke-60 dan hari ke-90. Analisis data secara statistik menggunakan SPSS metode two way ANNOVA. Hasil penelitian menunjukkan bahwa pengemas plastik dapat menurunkan viskositas dan pH. Kombinasi polietilen glikol (PEG) 400 dan polietilen glikol (PEG) 4000 dapat membentuk formula optimum dengan perbandingan 67% polietilen glikol (PEG) 400 dan 28% polietilen glikol (PEG) 4000 dalam rancangan formula. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2022-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/1254 10.35451/jfm.v5i1.1254 JURNAL FARMASIMED (JFM); Vol. 5 No. 1 (2022): Jurnal Farmasimed (JFM); 39-46 Jurnal FARMASIMED (JFM); Vol 5 No 1 (2022): Jurnal Farmasimed (JFM); 39-46 2655-0814 10.35451/jfm.v5i1 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/1254/661 Copyright (c) 2022 Neti Afriyani, Hari Susanti, Nining Sugihartini

oai:ejournal.medistra.ac.id:article/1258 2023-11-23T04:15:37Z JFM:YRS

EFFECTIVENESS TEST ON PREPARATION GEL (Aleurites moluccana) AS ANTICEPTIC HAND SANITIZER AGAINST BACTERIA Staphylococcus aureus Cahya, Cucu Arum Dwi Lubis, Devi Febby Yola Minyak kemiri Hand sanitizer Staphylococcus aureus Salah satu cara yang efektif untuk menjaga kesehatan tubuh adalah dengan menjaga kebersihan, salah satunya adalah kebersihan tangan. Salah satu bakteri yang paling sering mengkontaminasi kulit tangan adalah Staphylococcus aureus. Penggunaan gel antiseptik (Hand sanitizer) yang mudah dan praktis semakin diminati masyarakat. Kebanyakan produk gel antiseptik tangan menggunakan alkohol sebagai antibakteri. Kemiri adalah salah satu tumbuhan dengan berbagai manfaat pada setiap bagian pohonnya. Kemiri dapat dimanfaatkan baik sebagai obat-obatan tradisional, bahan makanan, bahan pewarna, penerangan dan berbagai kegunaan lain. Namun belum ada studi yang meneliti apakah formulasi sediaan Gel Hand sanitizer minyak kemiri (Aleurites moluccana) efektif sebagai antibakteri. Penelitian ini untuk mengetahui efektivitas antibakteri minyak kemiri terhadap bakteri Staphylococcus aureus setelah diformulasikan dalam sediaan gel Hand sanitizer pada 3 formula dengan konsentrasi F1=5%, F2=10% dan F3=15%. Penelitian ini adalah penelitian eksperimental. Untuk mengetahui efektivitas anti bakteri minyak kemiri (Aluerites moluccana) terhadap bakteri Staphylococcus. aureus setelah diformulasikan kedalam sediaan gel Hand sanitizer. Penelitian ini menunjukkan bahwa pada formulasi F3 dengan kosentrasi 15% dapat menghambat aktivitas bakteri Staphylococcus aureus dengan zona hambat sebesar 19 mm dengan hasil sediaan gel yang homogen, pH sebesar 5 mendekati pH kulit, tidak mengiritasi kulit dan daya sebar menunjukkan hasil yang merata ke seluruh permukaan kulit yaitu 5 cm. Terdapat penghambatan bakteri Staphylococcus aureus setelah minyak kemiri (Aleurites moluccana) diformulasikan kedalam sediaan gel Hand sanitizer. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2023-04-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/1258 10.35451/jfm.v5i2.1258 JURNAL FARMASIMED (JFM); Vol. 5 No. 2 (2023): Jurnal Farmasimed (JFM); 114-121 Jurnal FARMASIMED (JFM); Vol 5 No 2 (2023): Jurnal Farmasimed (JFM); 114-121 2655-0814 10.35451/jfm.v5i2 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/1258/725 Copyright (c) 2023 Cucu Arum Dwi Cahya, Devi Febby Yola Lubis http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ejournal.medistra.ac.id:article/1276 2023-11-23T04:16:15Z JFM:YRS

COVID-19 PREPAREDNESS ANALYSIS OF DELI SERDANG REGIONAL GENERAL HOSPITAL LUBUK PAKAM INDONESIA Kartika, Dewi - Matury, Herlina J. El Karo-Karo, Tati Murni Kasim, Felix WHO checklis, kesiapsiagaan, COVID-19 Indonesia menghadapi berbagai bencana alam dan non alam seperti gempa bumi, tsunami, banjir, tanah longsor, gunung berapi, pandemi COVID-19. Fasilitas pelayanan kesehatan harus dapat diakses dan berfungsi selama dan segera setelah bencana. Penelitian ini bertujuan untuk mengkaji kesiapsiagaan Rumah Sakit Umum Daerah Deli Serdang dalam menghadapi pandemi COVID-19. Penelitian ini menggunakan pendekatan metode campuran. Pengumpulan data dilakukan melalui wawancara, observasi, dan telaah dokumen dengan mengacu pada pedoman dalam WHO Checklist COVID-19. Variabel yang diteliti adalah kepemimpinan dan sistem manajemen dengan percent achievement 93%; koordinasi dan komunikasi 92%; survailans dan manajemen informasi 92%; komunikasi risiko dan keterlibatan masyarakat 100%; administrasi, keuangan dan keberlanjutan bisnis 69%; SDM 75%; surge capacity 80%; keberlanjutan layanan pendukung esensial 83%; manajemen pasien 63%; kesehatan kerja, mental dan dukungan psikososial 70%; identifikasi dan diagnosis cepat 92%; pencegahan dan pengendalian infeksi 84%. Skor indeks keselamatan adalah 0,826 yang di klasifikasikan pada level A, rumah sakit siap menghadapi pandemi COVID-19, namun tetap perlu dilakukan usaha pencegahan jangka panjang untuk meningkatkan keselamatan bencana. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2022-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/1276 10.35451/jfm.v5i1.1276 JURNAL FARMASIMED (JFM); Vol. 5 No. 1 (2022): Jurnal Farmasimed (JFM); 47-51 Jurnal FARMASIMED (JFM); Vol 5 No 1 (2022): Jurnal Farmasimed (JFM); 47-51 2655-0814 10.35451/jfm.v5i1 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/1276/662 Copyright (c) 2022 Dewi Kartika, Herlina J. El - Matury, Tati Murni Karo-Karo, Felix Kasim, Romauli Anna Teresia Marbun

oai:ejournal.medistra.ac.id:article/1279 2023-11-23T04:16:15Z JFM:YRS

ANTI-INFLAMMATORY EXCITIVITY TEST OF SINTRONG LEAF ETHANOL EXTRACT (Crassocephalum crepidiodes) ON MALE WHITE MICE Sumitra, Jhoti Pasaribu, Esra Navita Rida Antiinflamasi daun sintrong pletismometer karagenan Sintrong (Crassocephalum crepidioides) merupakan kelompok tanaman dengan batang lunak yang dipercaya bisa mengobati berbagai macam penyakit, seperti gangguan pencernaan, sakit kepala, sakit perut, mengobati luka, antelmetik, antiinflamasi, antidiabetes, dan antimalaria. Daun sintrong mengandung senyawa metabolit sekunder yaitu flavonoid yang diketahui memiliki aktivitas sebagai antiinflamasi. Penelitian ini bertujuan untuk mengetahui efektivitas antiiinflmasi ekstrak etanol daun sintrong (Crassocephalum crepidiodes) terhadap mencit putih jantan. Penelitian ini adalah penelitian eksperimental yang dibagi menjadi 5 kelompok yaitu Natrium Diklofenak, kontrol negatif Na-Cmc 0,5 %, dan EEDS dosis 100, 200 dan 300 mg/kgBB. Data hasil penelitian dihitung persen radang dan persen inhibisi radang. Data dianalisis secara statistik menggunakan metode Anova dan dilanjutkan dengan uji Duncan. Hasil penelitian menunjukkan bahwa EEDS 300 mg/kgBB memiliki inhibisi radang paling besar dibanding ekstrak 100 dan 200 mg/kgBB. Hasil uji one way Anova menunjukkan adanya perbedaan yang signifikan (P>0,05)   antar kelompok perlakuan. Hasil uji Duncan menunjukkan kelompok yang memberikan efektivitas antiinflamasi terbaik adalah kontrol positif dan EEDS 300 mg/kgBB. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2022-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/1279 10.35451/jfm.v5i1.1279 JURNAL FARMASIMED (JFM); Vol. 5 No. 1 (2022): Jurnal Farmasimed (JFM); 52-56 Jurnal FARMASIMED (JFM); Vol 5 No 1 (2022): Jurnal Farmasimed (JFM); 52-56 2655-0814 10.35451/jfm.v5i1 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/1279/663 Copyright (c) 2022 Jhoti Sumitra, Esra Navita Rida Pasaribu

oai:ejournal.medistra.ac.id:article/1280 2023-11-23T04:16:15Z JFM:YRS

ACTIVITY TEST ETHANOL EXTRACT MATOA (POMETIA PINNATA) ANTINFLAMMATION AGAINST MALE RATS INDUCED CARAGENAN Turnip, Nur Ulina M. Br. Panjaitan, Yudika Levanda Antiinflamasi Daun matoa Pletismometer Karagenan Matoa merupakan salah satu tanaman dari famili Sapindaceae yang tersebar di daerah tropis, termasuk Indonesia. Tanaman matoa banyak digunakan masyarakat dalam pengobatan tradisional. Penelitian ini dilakukan dengan tujuan untuk mengetahui efek antiinflamasi ekstrak etanol daun matoa (Pometia pinnata) terhadap mencit putih jantan yang di induksi karagenan. Penelitian ini adalah penelitian eksperimental yang dibagi menjadi 5 kelompok yaitu kontrol positif (Natrium Diklofenak 6,5 mg/kgBB), kontrol negatif (Na-CMC 0,5%) dan tiga dosis yang diuji yaitu 100 mg/kgBB, 200 mg/kgBB dan 300 mg/kgBB. Metode dalam penelitian ini adalah dengan induksi karagenan 0,1 ml sebagai iritan pada telapak kaki mencit selama 360 menit dengan parameter yang diamati adalah penghambatan udem kaki mencit menggunakan pletismometer. Hasil penelitian ini menunjukkan adanya perbedaan yang signifikan (P>0,05) dengan kesimpulan tiga dosis yang diuji yaitu 100 mg/kgBB, 200 mg/kgBB dan 300 mg/kgBB memiliki efek antiinflamasi dimana dosis yang lebih efektif adalah 300 mg/kgBB. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2022-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/1280 10.35451/jfm.v5i1.1280 JURNAL FARMASIMED (JFM); Vol. 5 No. 1 (2022): Jurnal Farmasimed (JFM); 57-61 Jurnal FARMASIMED (JFM); Vol 5 No 1 (2022): Jurnal Farmasimed (JFM); 57-61 2655-0814 10.35451/jfm.v5i1 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/1280/664 Copyright (c) 2022 Nur Ulina M. Br. Turnip, Yudika Levanda Panjaitan

oai:ejournal.medistra.ac.id:article/1294 2023-11-23T04:16:15Z JFM:YRS

PROFILE OF USE OF PREGNANT WOMEN SUPPLEMENTS IN THREE PHARMACIES LOCATED IN KARAWANG Hamidah, Nur Assyifa Salman, Salman Gethera, Vesara Ardhe Gizi, Apotek, Ibu Hamil, Resep, Suplemen Kebutuhan gizi pada masa kehamilan akan meningkat sebesar 15% dibandingkan dengan kebutuhan wanita normal. Peningkatan gizi ini dibutuhkan untuk pertumbuhan rahim (uterus), payudara (mammae), volume darah, plasenta, air ketuban dan pertumbuhan janin. Gizi yang tidak terpenuhi akan berbahaya baik untuk ibu maupun untuk janin yang dikandung, Gizi yang kurang atau Malnutrisi selama masa kehamilan dapat menyebabkan kerusakan pada organ vital serta mengakibatkan komplikasi kesehatan yang serius baik bagi ibu maupun janin. Pada ibu hamil yang mengalami malnutrisi, makanan bergizi saja tidak cukup untuk memenuhi zat gizi yang kurang, maka dari itu diperlukannya suplemen untuk membantu memulihkan keadaannya dan menjaga janin agar tetap tumbuh dan berkembang dengan baik.Penelitian ini bertujuan untuk menggambarkan jumlah penggunaan suplemen ibu hamil yang dilihat berdasarkan data dalam resep kemudian dimasukan kedalam microsoft excel, dan mengetahui indikasi suplemen tersebut berdasarkan informasi yang ada dalam mims serta mengetahui ada atau tidaknya interaksi obat dengan suplemen maupun suplemen dengan suplemen berdasarkan informasi yang ada pada drugs.com di tiga apotek di karawang Penelitian ini menggunakan metode deskriptif, kualitatif-kuantitatif didukung dengan adanya data primer yang menggunakan data resep. Hasil penelitian ini menunjukan bahwa dari ke tiga apotek, penggunaan suplemen terbanyak adalah Vitamin B kompleks yang termasuk dalam golongan vitamin dan mineral serta tidak adanya interaksi obat yang terjadi di ketiga apotek yang dijadikan tempat penelitian kali ini. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2022-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/1294 10.35451/jfm.v5i1.1294 JURNAL FARMASIMED (JFM); Vol. 5 No. 1 (2022): Jurnal Farmasimed (JFM); 62-72 Jurnal FARMASIMED (JFM); Vol 5 No 1 (2022): Jurnal Farmasimed (JFM); 62-72 2655-0814 10.35451/jfm.v5i1 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/1294/665 Copyright (c) 2022 Nur Assyifa Hamidah, Salman Salman, Vesara Ardhe Gethera

oai:ejournal.medistra.ac.id:article/1295 2023-11-23T04:15:37Z JFM:YRS

ANALIYSIS OF RHODAMINE B DYESTUFFS ON LIPTINT USING UV-VIS SPECTROPHOTOMETRY METHOD wulandari, suci Rahma, Amalia Nur Wahyuni, Siti Lubis, Basyariah Liptint, Rhodamine B, Spectrophotometry UV-VIS. Background : Rhodamine B is a synthetic dye that is generally used as a dye for paper, textiles or inks. The use of Rhodamine B is certainly very dangerous for health. Rhodamine B if used directly on the human body will cause irritation of the respiratory tract and can cause cancer and liver damage. Although there are negative impacts, the use of these dyes is still often done, especially for food and cosmetic products. Purpose : This research was conducted to identify and determine levels of Rhodamine B in liptint traded in  Lubuk Pakam sub-District. Method : Qualitative analysis of Rhodamine B was carried out by Thin Layer Chromatography (TLC) using ethylacetate-methanol-ammonia (45:25:30), while quantitative analysis for assay was carried out using UV-VIS Spectrophotometry at a wavelength of 545 nm. The linear calibration curve in the range of 1 - 5 ?g /ml resulted in the regression equation y = 0.0091x - 0.009. Results : The results of the qualitative analysis showed that the three samples containing Rhodamine B with each Rf value of 0.87 cm (sample A), 0.96 cm (sample B), 0.98 cm (sample C) and quantitatively the levels for sample A were known is 13,144 mg/g, sample B is 27,704 mg/g and sample C is 20,386 mg/g. Conclusion : From this research, it is known that there is still the use of Rhodamine B as a dye in liptint traded in Lubuk Pakam sub-district Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2023-04-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/1295 10.35451/jfm.v5i2.1295 JURNAL FARMASIMED (JFM); Vol. 5 No. 2 (2023): Jurnal Farmasimed (JFM); 184-191 Jurnal FARMASIMED (JFM); Vol 5 No 2 (2023): Jurnal Farmasimed (JFM); 184-191 2655-0814 10.35451/jfm.v5i2 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/1295/764 Copyright (c) 2023 suci wulandari, Amalia Nur Rahma, Siti Wahyuni, Basyariah Lubis

oai:ejournal.medistra.ac.id:article/1308 2023-11-23T04:15:37Z JFM:YRS

EVALUATION OF ANTIBIOTICS USE IN DALU SEPULUH PUSKESMAS TANJUNG MORAWA anggraeni, Ratih Samgryce Siagian, Hartika Anggraini Sembiring, Syaiba Antibiotik, Tingkat penggunaan, Puskesmas Dalu Sepuluh Antibiok sering digunakan untuk mengatasi infeksi bakteri. Kurangnya pengetahuan masyarakat tentang penggunaan antibiotik menjadi salah satu faktor resiko terjadinya peningkatan resiko bakteri terhadap antibiotik. Penelitian ini bertujuan untuk mengetahui bagaimana tingkat pemahaman tentang penggunaan antibiotik di puskesmas Dalu sepuluh Tanjung Morawa. Desain penelitian ini adalah penelitian deskriptif dengan tehnik sampel yaitu purposive sampling pada subjek sebanyak 70 orang tanjung morawa. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2023-04-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/1308 10.35451/jfm.v5i2.1308 JURNAL FARMASIMED (JFM); Vol. 5 No. 2 (2023): Jurnal Farmasimed (JFM); 122-126 Jurnal FARMASIMED (JFM); Vol 5 No 2 (2023): Jurnal Farmasimed (JFM); 122-126 2655-0814 10.35451/jfm.v5i2 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/1308/727 Copyright (c) 2023 Ratih anggraeni, Hartika Samgryce Siagian, Syaiba Anggraini Sembiring http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ejournal.medistra.ac.id:article/1314 2023-11-23T04:16:15Z JFM:YRS

EVALUATION OF ANTIBIOTICS USAGE RATIONALITY ON DIABETES MELLITUS TYPE II PATIENTS AT INPATIENT INSTALLATION OF GRANDMED HOSPITAL LUBUK PAKAM IN 2022 Meirita, Efilia Sari, Anita Diabetes melitus tipe II rasionalitas evaluasi penggunaan antibiotik Latar Belakang: Diabetes Melitus (DM) adalah sekelompok penyakit metabolik dengan karakteristik hiperglikemia yang berhubungan dengan gangguan metabolisme karbohidrat, lemak dan protein sebagai akibat adanya difesiensi sekresi insulin, penurunan efektivitas insulin maupun keduanya. Penggunaan antibiotik yang tidak rasional akan menimbulkan dampak negatif seperti masalah resistensi dan potensinya terjadinya kejadian efek samping. Penelitian ini bertujuan untuk mengetahui gambaran dan mengevaluasi penggunaan antibiotik pada pasien diabetes melitus tipe II di Rumah Sakit Grandmed Lubuk Pakam Tahun 2022 sebanyak 57 pasien. Metode: Penelitian ini merupakan jenis penelitian non eksperimental dengan pengumpulan data secara retrospektif dan dianalisis secara deskriptif berdasarkan tepat indikasi, tepat obat, tepat dosis dan tepat lama pemberian.  Hasil: Hasil penelitian dari 57  penderita diabetes melitus tipe II diketahui bahwa jenis kelamin laki-laki 28,1% (16 pasien) dan jenis kelamin perempuan 71,9% (41 pasien). Berdasarkan usia 36-48 tahun 14,0% (8 pasien), usia 49-58 tahun 28,1% (16 pasien) dan usia 59-68 tahun 57,9% (33 pasien). Pola penggunaan antibiotik tunggal dan antibiotik kombinasi. Penggunaan antibiotik tunggal yaitu ceftriaxone 65,8%, meropenem 18,4%, levofloxacin 7,9% dan metronidazole 7,9%. Penggunaan antibiotik kombinasi yaitu ceftriaxone + metronidazole 78,9%, meropenem + metronidazole 10,5% dan levofloxacin + metronidazole 10,5%. Kesimpulan: Dapat disimpulkan bahwa terdapat 34 pasien (59,6%) yang sudah mendapatkan terapi pengobatan yang rasional dan 23 pasien (40,4%) yang belum mendapatkan terapi secara rasional berdasarkan parameter yaitu tepat indikasi 100%, tepat obat 89,5%, tepat dosis 86,0% dan tepat lama pemberian 82,5%. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2022-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/1314 10.35451/jfm.v5i1.1314 JURNAL FARMASIMED (JFM); Vol. 5 No. 1 (2022): Jurnal Farmasimed (JFM); 73-79 Jurnal FARMASIMED (JFM); Vol 5 No 1 (2022): Jurnal Farmasimed (JFM); 73-79 2655-0814 10.35451/jfm.v5i1 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/1314/667 Copyright (c) 2022 Efilia Meirita, Anita Sari

oai:ejournal.medistra.ac.id:article/1315 2023-11-23T04:16:15Z JFM:YRS

The EVALUATION OF THE USE OF ANTI-INFLAMMATORY DRUGSIN PATIENTS RHEUMATOID ARTHRITIS OUTPATIENT AT GRANDMED HOSPITAL LUBUK PAKAM Sihombing, Yanna Rotua Marbun, Romauli Anna Teresia Zebua, Kristian Cahayani Lestari, Dayana Rheumatoid Arthritis, Outpatient, Anti-inflammatory, Rationality. Rheumatoid arthritis is an autoimmune disease characterized by inflammation of the joints that can become chronic. Rational use of drugs aims to ensure that patients get safe and effective treatment in the right time frame and at an affordable price according to their needs In the outpatient facility of Lubuk Pakam Hospital, patients experience symptoms such as pain, inflammation, morning joint stiffness and difficulty moving at appropriate doses. This study aims to aim to obtain an objective picture or picture of the situation. Data collection was carried out retrospectively, namely by observing the medical records of rheumatoid arthritis patients at Grandmed Lubuk Pakam Hospital in 2021. A total of 13 (56.5%) female patients and 10 (56.5%) (43.5%) male patients, according to the number of rheumatoid arthritis patients at the outpatient facility of GrandMed Lubuk Pakam Hospital in 2021. This makes the inclusion criteria for all anti-inflammatory agents incomplete in rheumatoid arthritis and the exclusion criteria for all medical records in rheumatoid arthritis patients. Analysis of data based on age, gender, rationality of the drug, correct indications, correct patient, correct drug, correct dosage. The Outpatient Study of GrandMed Lubuk Pakam Hospital 2021 is: Correct Indications (100%), Correct Patients (100%), Correct Drugs (100%), Correct Dosage (91.3%). The treatment of patients with rheumatoid arthritis at GrandMed Lubuk Pakam Hospital can still be said to be fully good Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2022-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/1315 10.35451/jfm.v5i1.1315 JURNAL FARMASIMED (JFM); Vol. 5 No. 1 (2022): Jurnal Farmasimed (JFM); 80-86 Jurnal FARMASIMED (JFM); Vol 5 No 1 (2022): Jurnal Farmasimed (JFM); 80-86 2655-0814 10.35451/jfm.v5i1 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/1315/668 Copyright (c) 2022 Yanna Rotua Sihombing, Kristian Cahayani Zebua, Dayana Lestari

oai:ejournal.medistra.ac.id:article/1319 2023-11-23T04:15:37Z JFM:YRS

FORMULATION EXTRACT LEAVES TEAK (TECTONA GRANDIS) AS PREPARATION DYE NAIL NATURAL PRODUCT Rani, Yosi Darmi daun jati pewarna kuku konsentrasi Daun jati merupakan tumbuhan yang memiliki kualitas tinggi  daun yang berukuran besar berbentuk jantung membulat dan dapat dimanfaatkan sebagai pembungkus makanan. Kandungan daun jati tersebut memiliki zat pewarna antosianin yang cukup tinggi sehingga warna yang dihasilkan berwarna merah pekat. Senyawa antosianin merupakan senyawa metabolit sekunder dari famili flavonoid. Pewarna kuku adalah sediaan rias kuku yang digunakan untuk maksud menyalut kuku dengan lapisan tidak bewarna atau mewarnai kuku dengan warna  baik warna kemudahan maupun warna kontras nyata  sesuai dengan estetika kuku yang dikehendaki. Tujuan penelitian ini adalah untuk mengetahui penggunaan ekstrak daun jati (Tectona grandis) yang lebih baik dengan perbedaan kosentrasi 5%  10%  atau 15%.. Jenis penelitian ini adalah penelitian eksperimental  dengan menggunakan ekstrak daun jati dengan kosentrasi 5%  10%  15%. Uji yang dilakukan terhadap sediaan adalah uji homogenitas  uji organoleptis  uji pH  uji iritasi  dan uji daya sebar. Hasil penelitiaan pada pewarna kuku dengan kosentrasi 5% mengahasilkan warna coklat  pada kosentrasi 10% memiliki warna coklat tua  dan pada kosentrasi 15% menghasilkan warna merah pekat. Kosentrasi yang baik pada pewarna kuku adalah kosentrasi 5% dengan pH 5. Kesimpulan: Ekstrak daun jati (Tectona grandis) dapat menghasilkan warna dan dapat diformulasikansebagai pewarna alami pada sediaan cat kuku dengan varian kosentrasi  dan kosentrasi 5% menghasilkan warna yang lebih baik dan terang pada sediaan cat kuku. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2023-04-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/1319 10.35451/jfm.v5i2.1319 JURNAL FARMASIMED (JFM); Vol. 5 No. 2 (2023): Jurnal Farmasimed (JFM); 127-131 Jurnal FARMASIMED (JFM); Vol 5 No 2 (2023): Jurnal Farmasimed (JFM); 127-131 2655-0814 10.35451/jfm.v5i2 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/1319/728 Copyright (c) 2023 yosi darmi rani http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ejournal.medistra.ac.id:article/1321 2023-11-23T04:16:15Z JFM:YRS

EVALUATION OF ANTIDIABETIC USAGE IN TYPE II DM PATIENTS AT PUBLIC HEALTH CENTRE OF SEI KEPAYANG BARAT ASAHAN DISTRICT Rahayu, Yayuk Suyudi Anggraeni, Ratih Tanjung, Nurhaliza antidiabetes, DM tipe II Diabetes Melitus merupakan suatu kondisi dengan gangguan metabolik karena organ pankreas gagal memproduksi hormon insulin. Kondisi ini digolongkan penyakit kronis karena berlangsung menahun. Diabetes melitus digolongkan menjadi tiga jenis, yaitu DM tipe I, II, dan gestasional. Evaluasi penggunaan antidiabetes bertujuan untuk mendukung program pemerintah secara terstruktur dan berkesinambungan dalam hal mengontrol penggunaan obat diabetes secara kualitatif dan kuantitatif. Evaluasi ini menggunakan metode deskriptif kuantitatif berdasarkan tepat obat, tepat dosis, tepat indikasi, dan tepat pasien dengan hasil bahwa pravelensi pasien DM tipe II sering terjadi pada perempuan berusia 40-55 tahun. Evaluasi penggunaan antidiabetes di Puskesmas Sei Kepayang Barat terlaksana sesuai ketentuan dan mengacu pada Keputusan Mentri Kesehatan Tahun 2016. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2022-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/1321 10.35451/jfm.v5i1.1321 JURNAL FARMASIMED (JFM); Vol. 5 No. 1 (2022): Jurnal Farmasimed (JFM); 87-91 Jurnal FARMASIMED (JFM); Vol 5 No 1 (2022): Jurnal Farmasimed (JFM); 87-91 2655-0814 10.35451/jfm.v5i1 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/1321/669 Copyright (c) 2022 Yayuk Suyudi Rahayu, Ratih Anggraeni, Nurhaliza Tanjung

oai:ejournal.medistra.ac.id:article/1337 2023-11-23T04:16:15Z JFM:YRS

QUALITATIVE ANALYSIS OF WET AND DRY FISH FORMALIN FROM PANCUR BATU MARKET TRADERS Suprianto, Suprianto Chan, Adek Samran, Samran Meilani, Debi Nasution, Lely Fitri Handayani Analisa Kualitatif Formalin Ikan Basah dan Kering Ikan salah satu dari sekian banyak kekayaan alam bahari Indonesia. Lauk pauk ikan banyak dikonsumsi masyarakat, mudah diperoleh di pasar dengan harga terjangkau. Namun ikan basah dan ikan kering mudah dan cepat mengalami pembusukan. Mikroba ada sejak ikan masih hidup. Aktivitas mikroba menyebabkan perubahan biokimia dan fisik ikan sehingga bau busuk. Kondisi busuk diketahui setelah bau busuk tersebar dan timbul lendir, warna suram, mata keruh dan sebagainya. Pengawetan ikan basah dan ikan kering dilakukan dengan mengurangi kadar air. Pengawetan merupakan daya upaya peyelamatan hasil tangkapan ikan oleh nelayan. Pembusukan ikan dihambat dengan penambahan garam, sehingga penyimpanan ikan lebih lama tanpa aktivitas bakteri dan enzim. Pesatnya teknik pengolahan pangan, penambahan bahan-bahan aditif pada bahan pangan sulit untuk dihindari, akibatnya keamanan pangan telah menjadi dasar pemilihan suatu produk pangan yang akan dikonsumsi. Bahan aditif berbahaya sulit dihindari, selalu ditemukan dalam pangan. Tujuan penelitian untuk mengetahui keberadaan formalin sebagai pengawet dalam ikan basah dan ikan kering dari pedagang pasar Pancur Batu secara kualitatif dengan pereaksi tertentu. Penelitian deskriptif menggunakan masing-masing lima sampel ikan basah dan kering yang dijual di pasar Pancur Batu. Hasil penelitian memberikan informasi satu sampel ikan dari pedagang pasar Pancur Batu mengalami perubahan warna ungu pada Kit Tes. Satu dari kelima sampel ikan basah dan kering positif ada formalin. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2022-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/1337 10.35451/jfm.v5i1.1337 JURNAL FARMASIMED (JFM); Vol. 5 No. 1 (2022): Jurnal Farmasimed (JFM); 92-98 Jurnal FARMASIMED (JFM); Vol 5 No 1 (2022): Jurnal Farmasimed (JFM); 92-98 2655-0814 10.35451/jfm.v5i1 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/1337/670 Copyright (c) 2022 Suprianto Suprianto, Adek Chan, Samran Samran, Debi Meilani, Lely Fitri Handayani Nasution

oai:ejournal.medistra.ac.id:article/1340 2023-11-23T04:16:15Z JFM:YRS

THE EFFECT OF SUGARCANE LEAF EXTRACT ON MALONDIALDEHYDE PLASMA LEVELS IN CARBON TETRACHLORIDE-INDUCED RATS Dewi, Ika Puspita Ulinnuha, Jihan Ulya Holidah, Diana karbon tetraklorida, daun tebu, malondialdehid, tikus Peroksidasi lipid akibat radikal bebas dapat menyebabkan kematian sel yang dapat merusak berbagai organ, termasuk liver. Hal ini dapat ditandai dengan peningkatan kadar malondialdehid. Pengukuran parameter ini pada darah dan organ digunakan sebagai penanda adanya stres oksidatif. Radikal bebas akibat peroksidasi lipid dapat diredam dengan senyawa antioksidan. Beberapa penelitian telah membuktikan aktivitas antioksidan tebu (Saccharum officinarum). Daun tebu dan jus tebu dari varietas yang berbeda-beda telah menunjukkan sifat antioksidan yang baik. Penelitian ini dilakukan untuk mengetahui efek ekstrak etanol tebu dengan berbagai dosis terhadap kadar malondialdehid plasma tikus yang diinduksi stress oksidatif dengan karbon tetraklorida (CCl4). Daun tebu diekstraksi dengan maserasi dengan pelarut etanol 96%. Pembuatan kurva baku malondialdehid dilakukan dengan seri larutan 1,1,2,2-tetraethoxypropane. Pengujian dilakukan terhadap hewan uji tikus Wistar yang dibagi menjadi beberapa kelompok. Pembagian kelompok meliputi kelompok normal tanpa induksi CCl4 diberikan CMC-Na 1%; kontrol negatif diberikan CMC-Na 1%; kontrol positif diberikan Silybum marinum yang 100 mg/kgBB; kelompok dosis yang terdiri atas 300, 400, dan 500 yang masing-masing diberikan ekstrak etanol daun tebu dosis dengan dosis 300 mg/kgBB, 400 mg/kgBB dan 500 mg/kgBB berturut-turut. Tikus diperlakukan sepanjang 14 hari lalu diambil sampel plasmanya pada hari ke-15 untuk pengukuran kadar malondialdehid. Hasil ekstraksi daun tebu mendapatkan rendemen sebesar 16,05%. Kurva baku yang digunakan untuk mengukur malondialdehid plasma tikus adalah y = 0,0059x + 0,0238. Hasil menunjukkan pemberian ekstrak daun tebu semua dosis memiliki nilai malondialdehid yang lebih rendah dibandingkan kontrol negatif. Dosis 400 mg/kgBB tidak memiliki perbedaan signifikan dengan kontrol positif, sedangkan dosis 500 mg/kgBB lebih rendah dibanding dengan kontrol positif. Hal ini diduga karena metabolit sekunder seperti flavon yang terdapat pada ekstrak yang dapat meredam radikal bebas. Ekstrak etanol daun tebu dapat berperan sebagai antioksidan dengan menurunkan kadar malondialdehid darah tikus terinduksi CCl4. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2022-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/1340 10.35451/jfm.v5i1.1340 JURNAL FARMASIMED (JFM); Vol. 5 No. 1 (2022): Jurnal Farmasimed (JFM); 99-106 Jurnal FARMASIMED (JFM); Vol 5 No 1 (2022): Jurnal Farmasimed (JFM); 99-106 2655-0814 10.35451/jfm.v5i1 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/1340/671 Copyright (c) 2022 Ika Puspita Dewi, Jihan Ulya Ulinnuha, Diana Holidah

oai:ejournal.medistra.ac.id:article/1358 2023-11-23T04:15:37Z JFM:YRS

THE RELATIONSHIP OF KNOWLEDGE LEVEL ON THE BEHAVIOR OF RATIONAL ANTASIDA USE IN SWAMEDICATION ., Marselina Tingkat pengetahuan Perilaku Swamedikasi Antasida Gastritis merupakan inflamasi lapisan mukosa lambung dengan gejala nyeri lambung, mual, muntah, lemas, perut kembung, terasa sesak, nyeri uluh hati, tidak nafsu makan, bersendawa serta dapat terjadi perdarahan saluran cerna. Gastritis merupakan salah satu penyakit yang umumnya diderita oleh kalangan remaja yang menganggu aktivitas sehari-hari, sehingga diperlukannya kemudahan pengobatan untuk menanganinya. Golongan obat untuk penanganan gastritis yang dapat digunakan untuk pengobatan sendiri dan diperoleh tanpa resep dokter yaitu antasida. Tingginya kasus gastritis di kalangan remaja disertai tingginya prevalensi mahasiswa yang melakukan pengobatan sendiri harus dilakukan secara rasional, agar tujuan penggunaan obat tercapai. Namun pada pelaksanaan swamedikasi dapat berpeluang terjadinya masalah terkait obat akibat terbatasnya pengetahuan mengenai obat dan penggunannya. Maka peneliti akan melakukan penelitian untuk mengetahui hubungan tingkat pengetahuan terhadap perilaku penggunaan antasida yang rasional dalam swamedikasi pada mahasiswa tahun pertama di Universitas Medika Suherman yang memenuhi kriteria inklusi. Jenis penelitian ini adalah observasional analitik dengan metode cross sectional dan pengambilan sampel menggunakan metode purposive sampling serta instrument yang digunakan berupa kuesioner yang akan diisi responden. Penelitian ini didapatkan jumlah responden sebanyak 129 orang. Berdasarkan data penelitian didapatkan nilai koefisien korelasi yaitu 0.283?0.260, dan nilai signifikansi 0.001<0.050 sehingga dapat dinyatakan bahwa terdapat hubungan yang cukup kuat antara tingkat pengetahuan terhadap perilaku penggunaan antasida dalam swamedikasi pada responden yang mengalami gejala gastritis. Pada data didapatkan juga bahwa terdapat hubungan yang cukup kuat antara perilaku dengan lama penggunaan antasida dalam swamedikasi dengan nilai koefisien korelasi yaitu 0.289?0.260, dan nilai signifikansi 0.001<0.050. Penggunaan antasida yang rasional sebanyak 47.3% dan tidak rasional 52.7%. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2023-04-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/1358 10.35451/jfm.v5i2.1358 JURNAL FARMASIMED (JFM); Vol. 5 No. 2 (2023): Jurnal Farmasimed (JFM); 132-140 Jurnal FARMASIMED (JFM); Vol 5 No 2 (2023): Jurnal Farmasimed (JFM); 132-140 2655-0814 10.35451/jfm.v5i2 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/1358/729 Copyright (c) 2023 Marselina . http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ejournal.medistra.ac.id:article/1367 2023-11-23T04:16:15Z JFM:YRS

ANTIBACTERIAL EFFECTIVENESS TEST OF KECOMBRANG LEAVES (ETLINGERA ELATIOR) ETHANOL EXTRACT ON THE GROWTH OF PROPIONIBACTERIUM ACNES Wati, Siska Irwanto, Reno Cholilulah, Andreais Boffil Antibakteri, daun kecombrang, Propionibacterium acnes Propionibacterium acnes merupakan salah satu flora normal pada kulit yang berperan dalam timbulnya jerawat. Bila jumlahnya meningkat bakteri ini akan menjadi patogen dan menimbulkan lesi inflamasi pada kulit. Alternatif yang dapat dilakukan adalah dengan memanfaatkan bahan alamsebagai antibakteri yaitu tanaman kecombrang (Etlingera elatior). Tujuan dari penelitian ini adalahuntuk mengetahui efektivitas antibakteri ekstrak etanol daun kecombrang (Etlingera elatior) terhadappertumbuhan bakteri Propionibacterium acnes. Penelitian ini dilakukan dengan mengekstrak daunkecombrang (Etlingera elatior) dengan metode ekstraksi maserasi menggunakan etanol 96%. Metode: Uji daya hambat dilakukan dengan metode difusi cakram. Sampel terdiri dari 6 perlakuanyaitu ekstrak etanol daun kecombrang dengan konsentrasi 20%, 15%, 10%, 5%, kontrol positif DMSO dan  kontrol negatif clindamycin. Hasil penelitian menunjukan ekstrak etanol daun kecombrang dengankonsentrasi 20% mempunyai daya hambat sebesar 20,0 mm (kategori kuat), 15% sebesar 13,5 mm (kategori kuat), 10% sebesar 9,0 (kategori sedang), 5% sebesar 6,0 (kategori lemah). Kesimpulanpenelitian ini adalah daya hambat antibakteri terhadap bakteri Propionibacterium acnes dengankonsentrasi paling efektif adalah 20% dengan kategori kuat 20,0. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2022-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/1367 10.35451/jfm.v5i1.1367 JURNAL FARMASIMED (JFM); Vol. 5 No. 1 (2022): Jurnal Farmasimed (JFM); 107-113 Jurnal FARMASIMED (JFM); Vol 5 No 1 (2022): Jurnal Farmasimed (JFM); 107-113 2655-0814 10.35451/jfm.v5i1 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/1367/672 Copyright (c) 2022 Siska Wati, Reno Irwanto, Andreais Boffil Cholilulah

oai:ejournal.medistra.ac.id:article/1401 2023-11-23T04:15:37Z JFM:YRS

TRANSPARENT SOAP FORMULATION WITH VARIOUS LEVELS OF CONCENTRATION OF TEAK LEAF EXTRACT (TECTONA GRANDIS L.F.)AS ANTIBACTERIAL SOAP Pranata, Chandra Irwanto, Reno .S, Aminah Daun jati sabun transparan antibakteri The purpose of this study was to examine the organoleptic, homogeneity and antibacterial properties of transparent soap. The treatment used is; F1 (3% teak leaf extract), F2 (6% teak leaf extract), F3 (9% teak leaf extract), and F4 (12% teak leaf extract). The implementation of the research begins with product optimization in advance of the proportion of the use of raw material components. The results of the homogeneity test experiment showed that all formulas were homogeneous and in accordance with SNI standards, then the results of the water content obtained from each preparation proved to meet the requirements set by SNI ( Indonesian National Standard). The results of the pH measurements showed that at pH F0 it remained at 8. The results for measuring pH F1 showed results with a pH of 8. Meanwhile, pH F2 had a pH of 8. The last measurement for pH at pH F3 showed the same pH results as the other formula, namely at pH 8. So that F0, F1, F2, and F3 have the same pH, namely pH 8, where pH 8 is the pH of the positive control, namely soap on the market. Staphylococcus aureus with a concentration of 3% by 13 mm, 6% by 15 mm, 9% by 17 mm, 12% by 20 mm. The greater the concentration of teak leaf extract in transparent solid coir, the greater the inhibition of bacterial growth. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2023-04-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/1401 10.35451/jfm.v5i2.1401 JURNAL FARMASIMED (JFM); Vol. 5 No. 2 (2023): Jurnal Farmasimed (JFM); 192-197 Jurnal FARMASIMED (JFM); Vol 5 No 2 (2023): Jurnal Farmasimed (JFM); 192-197 2655-0814 10.35451/jfm.v5i2 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/1401/765 Copyright (c) 2023 Chandra Pranata, Reno Irwanto, Aminah .S http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ejournal.medistra.ac.id:article/1470 2023-11-23T04:15:37Z JFM:YRS

IDENTIFICATION OF PORK'S CYTOCHROME B GEN IN PROCESSED MEAT NUGGETS IN SUKABUMI VILLAGE, BUAY BAHUGA SUB-DISTRICT USING THE POLYMERASE CHAIN ??REACTION (PCR) METHOD Setiawati, Diah Ayu Marpaung, Mauritz Pandapotan Setiawansyah, Arif Nugget sitokrom b polymerase chain reaction (PCR) elektroforesis Nugget adalah jenis olahan daging restrukturisasi yang sangat rentan terhadap cemaran daging lainnya sehingga mempengaruhi kehalalan suatu produk makanan. Penelitian ini bertujuan untuk mengidentifikasi cemaran sitokrom b pada nugget yang beredar di Desa Sukabumi dengan menggunakan metode Polymerase Chain Reaction  (PCR). Sebanyak 3 buah  sampel nugget di desa Sukabumi diambil dari produsen yang berbeda dan divisualisasi dengan elektroforesis gel agarose 0,75%, dan divisualisasikan dengan alat documentation system. Hasil penelitian menunjukkan  berupa pita-pita marker DNA ledder yang masing-masing berjarak 100 bp. Untuk kontrol positif yang digunakan daging babi dengan marker 130 bp. Kesimpulan dari  penelitian ini adalah seluruh sampel tidak terindentifikasi adanya gen sitokrom b. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2023-04-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/1470 10.35451/jfm.v5i2.1470 JURNAL FARMASIMED (JFM); Vol. 5 No. 2 (2023): Jurnal Farmasimed (JFM); 141-147 Jurnal FARMASIMED (JFM); Vol 5 No 2 (2023): Jurnal Farmasimed (JFM); 141-147 2655-0814 10.35451/jfm.v5i2 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/1470/730 Copyright (c) 2023 Diah Ayu Setiawati, Mauritz Pandapotan Marpaung, Arif Setiawansyah http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ejournal.medistra.ac.id:article/1530 2023-11-23T04:15:37Z JFM:YRS

TESTING OF THE EFFECTS OF BALAKACIDA (CHROMOLAENA ODORATA L.) LEAF EXTRACT OINTMENT ON WOUND HEALING IN GUINEA PIGS Rosa, Vani Silvia Hasanah, Fenny Siahaan, Desy Natalia daun balakacida salep luka sayat marmut jantan Kulit ialah area terbesar tubuh yang berguna untuk melindungi tubuh dari bahaya kimia dan fisik seperti goresan, luka yang terinfeksi, dan luka bakar. Luka yakni hilangnya atau rusaknya beberapa jaringan tubuh. Daun balakacida (Chromolaena odorata L.) memiliki getah dan air yang berkhasiat menyembuhkan luka, dapat menghentikan pendarahan pada luka dan lecet dengan cukup cepat. Metode pada penelitian ini yakni eksperimental. Pembuatan ekstrak etanol daun balakacida didapat melalui maserasi dengan pelarut etanol, selanjutnya diformulasikan pada salep dengan ekstrak etanol daun balakacida pada berbagai konsentrasi 5%,7,5%,10%, selanjutnya dilakukan perbandingan dengan kontrol positif (Betadine) serta kontrol negatif (Basis salep). Hasil skrining yang didapat menyatakan ekstrak etanol daun balakacida mengandung senyawa tanin, flavonoid, saponin, alkoloid serta triterpenoid/steroid. Hasil penelitian yang diperoleh sediaan salep ekstrak etanol daun balakacida dengan konsentrasi 5%,7,5%, serta 10% mampu menyembuhkan luka sayat pada marmut. Semua konsentrasi telah menunjukkan kemampuan menyembuhkan luka sayat. Ekstrak etanol daun balakacidayang memberikan efek terbaik pada penyembuhan luka yakni konsentrasi 10%. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2023-04-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/1530 10.35451/jfm.v5i2.1530 JURNAL FARMASIMED (JFM); Vol. 5 No. 2 (2023): Jurnal Farmasimed (JFM); 148-156 Jurnal FARMASIMED (JFM); Vol 5 No 2 (2023): Jurnal Farmasimed (JFM); 148-156 2655-0814 10.35451/jfm.v5i2 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/1530/731 Copyright (c) 2023 Vani Silvia Rosa, Fenny Hasanah, Desy Natalia Siahaan

oai:ejournal.medistra.ac.id:article/1541 2023-11-23T04:15:37Z JFM:YRS

TEST OF EFFECT KEDONDONG LEAF ETHANOL EXTRACT (SPONDIAS DULCIS) ON STAPHYLOCOCCUS AUREUS BACTERIA Situmorang, Novidawati Boru Fatima, Nurdilla Teresia Marbun, Romauli Anna Sihombing, Yanna Rotua Anti-bacterial, Staphylococcus aureus , kedondong leaves Bacteria that cause infection and disease are commonly found in our environment, one of which is Staphylococcus aureus bacteria. Several infectious diseases are also caused by Staphylococcus aureus, including cellulitis, acne (acne), and infection with Staphylococcal Scalded Skin Syndrome (SSSS). To determine whether the ethanol extract of kedondong leaves (EEDK) has antibacterial activity against Staphylococcus aureus bacteria. This study used a laboratory experimental method with several stages such as sample collection, identification of plants for making simplicia, phytochemical screening, extract preparation and preparation of kedondong leaf extract test solutions with various concentrations of 15%, 25%, 35% and positive control (Chloramphenicol), negative control (DMSO), and antibacterial activity testing using the paper disc method. The results of phytochemical screening of kedondong leaf simplicia (Spondias dulcis) found that kedondong leaves contain secondary metabolites such as alkaloids, flavonoids, tannins and saponins that have the potential to inhibit bacterial growth. % of 9.4 mm, 25% concentration of 13.5 mm and the greatest inhibition was at a concentration of 35% of 19.5 mm. Kedondong leaf extract has antibacterial activity against the growth of Staphylococcus aureus bacteria, with moderate to strong categories. inhibit the activity of Staphylococcus aureus bacteria is a concentration of 35%. Based on the description above, it was found that the EED with a concentration of 35% had the greatest antibacterial effect compared to the concentration of 15% and 25%. and it can be concluded that the higher the concentration of the extract used, the higher the antibacterial effect. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2023-04-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/1541 10.35451/jfm.v5i2.1541 JURNAL FARMASIMED (JFM); Vol. 5 No. 2 (2023): Jurnal Farmasimed (JFM); 166-171 Jurnal FARMASIMED (JFM); Vol 5 No 2 (2023): Jurnal Farmasimed (JFM); 166-171 2655-0814 10.35451/jfm.v5i2 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/1541/732 Copyright (c) 2023 Novidawati Boru Situmorang, Nurdilla Fatima, Romauli Anna Teresia Marbun, Yanna Rotua Sihombing http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ejournal.medistra.ac.id:article/1584 2023-11-23T04:15:37Z JFM:YRS

ETHANOL EXTRACT LIQUID SOAP FORMULATION LEAVES OF CELERY (Apium graveolens L.) AGAINST Escherichia coli BACTERIA Irwanto, Reno Apriani Girsang, Santa Dewi Maria Ginting, Wira Novia, Reni Antibakteri, Daun Seledri, Sabun Dirty hands will be a source of disease. Soap is a pharmaceutical preparation used to maintain health. Celery (Apium graveolens L.) is a plant of the Apiaceae tribe with a distinctive menthol aroma. This study aimed to determine the inhibitory power of celery leaf extract formulation (Apium graveolens L.) as an antibacterial hand-washing soap. This research method is a type of experimental research. The stages of the research were collecting samples, identifying plants, making simplicia, characterizing simplicia, screening phytochemicals, making extracts and making hand soap formulations of celery leaf extract (Apium graveolens L) at concentrations of 5%, 10%, 15% and antibacterial testing of celery leaves, against Escherichia coli bacteria. The results showed the celery leaf extract soap formulation contained phytochemical compounds of flavonoids, tannins and saponins. The organoleptic test found that the best soap formulation was the F2 formulation with a concentration of 10% at an average level of preference value, namely 3.67 for colour, 3.27 for aroma, and 3.80 for texture. The homogeneity test performed showed that all formulations produced soap with good homogeneity. The height and stability test of the resulting celery extract soap foam ranged from 61-71 mm. The irritation test of the resulting celery extract soap also showed no irritation for all the formulations. The value of the antibacterial activity test found that the F1 formulation showed antibacterial activity with an inhibition zone diameter of 3 (weak), F2 with an inhibition zone of 9 (moderate) and F3 with the antibacterial activity of 12 (strong). Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2023-04-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/1584 10.35451/jfm.v5i2.1584 JURNAL FARMASIMED (JFM); Vol. 5 No. 2 (2023): Jurnal Farmasimed (JFM); 157-165 Jurnal FARMASIMED (JFM); Vol 5 No 2 (2023): Jurnal Farmasimed (JFM); 157-165 2655-0814 10.35451/jfm.v5i2 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/1584/733 Copyright (c) 2023 Reno Irwanto, Santa Dewi Apriani Girsang http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ejournal.medistra.ac.id:article/1587 2024-09-09T07:51:26Z JFM:YRS

ANTIDIABETIC ACTIVITY TEST OF ETHANOL EXTRACT BROCOLI (BRASSICA OLERACEA VAR. ITALICA) IN WHITE MALE RATS Purba, Novandi Handayani, Diah Tri Cahayani Zebua, Kristian Harefa, Karnirius Aloksan, Antidiabetes, Brokoli Diabetes is a chronic disease characterized by excessive blood glucose levels caused by absolute and relative insulin deficiency. The stages in this study were sampling, identification of samples/plants, simplification, simplification screening, and preparation of extracts by maceration. The method used in the diabetes activity test uses a glucometer to induce alloxan in rats at a dose of 150 mg/kg body weight. The test animals were 25 rats which were divided into 5 treatment groups namely CMC Na 0.5% (negative control), glibenclamide (positive control) 0.45 mg/kg body weight and EEB dose 200 mg/kg body weight, 400 mg/kg body weight and 600. mg/kg body weight. kg B.W. kg body weight as a test material given orally. Measurement of blood glucose values ??according to Allox and on days 3, 5, and 7 after administration of the test substance, namely EEB. The test results data were analyzed statistically using one-way ANOVA at a 95% confidence level followed by Tukey's post hoc test. The results of the phytochemical screening showed that EEB contains alkaloids, flavonoids, tannins, saponins, and glycosides. The results of the diabetes efficacy test showed that EEB doses of 200, 400, and 600 mg/kg BW had an anti-diabetic effect on male white rats. The EEB dose of 600 mg/kg is the most effective. Post hoc Tukey test results showed that EEB doses of 200 mg/kg, 400 mg/kg, and 600 mg/kg were not significantly different from the positive control glibenclamide 0.45 mg/kg (p>0.05) and 200,400 ug. and 600 mg/kg BW were significantly different from the negative control CMC Na 0.5% (p<0.05). Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2023-04-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/1587 10.35451/jfm.v5i2.1587 JURNAL FARMASIMED (JFM); Vol. 5 No. 2 (2023): Jurnal Farmasimed (JFM); 206-212 Jurnal FARMASIMED (JFM); Vol 5 No 2 (2023): Jurnal Farmasimed (JFM); 206-212 2655-0814 10.35451/jfm.v5i2 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/1587/768 Copyright (c) 2023 Novandi Purba, Diah Tri Handayani, Kristian Cahayani Zebua https://creativecommons.org/licenses/by-nd/4.0

oai:ejournal.medistra.ac.id:article/1613 2023-11-23T04:15:37Z JFM:YRS

EVALUATION OF THE USE OF ANTIHYPERTENSION DRUG IN HYPERTENSION PATIENTS AT THE GRANDMED LUBUK PAKAM HOSPITAL INSTALLATION IN 2022 Kartika, Dewi ., Suprianto Atika, Nur Hipertensi, Evaluasi penggunaan obat, Rawat Inap Hypertension is a condition where there is an increase in blood pressure that exceeds the normal limit, namely systolic blood pressure of more than 140 mmHg and diastolic blood pressure of more than 90 mmHg. Most women suffer from hypertension because of the hormone estrogen. Patients with hypertension who are not given proper therapy will cause complications that can worsen the condition of hypertension. The higher the prevalence of hypertension sufferers, the use of antihypertensive drugs will increase. This will increase the risk of irrational use of antihypertensive drugs. The purpose of this study was to evaluate the rationality of the use of antihypertensive drugs in the Inpatient Installation of Grandmed Lubuk Pakam Hospital based on the right patient, the right indication, the right drug and the right dose. This research is a type of descriptive research. Data collection was carried out retrospectively by using past data in the form of medical records of hypertension patients for the period January 2021 – February 2022 which met the exclusion and inclusion criteria. The sampling technique used was the purposive sampling technique. The results of this study indicate that the most widely used antihypertensive drugs are combination therapy with Calcium Channel Blokers (CCB) + Angiotensin Converting Enzyme Inhibitors (ACEI) (30,6%); Calcium Channel Blokers (CCB) sebanyak (11%); Calcium Channel Blokers (CCB) + Angiotensin Converting Enzyme Inhibitors (ACEI) + Diuretik sebanyak (11,1%); while the low class of drugs is Calcium Channel Blokers (CCB) + Angiotensin Converting Enzyme Inhibitors (ARB) + Angiotensin Converting Enzyme Inhibitors (ACEI); and diuretics + Angiotensin Converting Enzyme Inhibitors (ACEI) were used (2,8%). The results showed that the rationality of the use of antihypertensive drugs obtained was that the patient was correct 100%, the indication was 100%, the drug was 97,2%, and the dose was 97,2%. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2023-04-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/1613 10.35451/jfm.v5i2.1613 JURNAL FARMASIMED (JFM); Vol. 5 No. 2 (2023): Jurnal Farmasimed (JFM); 198-205 Jurnal FARMASIMED (JFM); Vol 5 No 2 (2023): Jurnal Farmasimed (JFM); 198-205 2655-0814 10.35451/jfm.v5i2 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/1613/766 Copyright (c) 2023 Dewi Kartika, Suprianto ., Nur Atika

oai:ejournal.medistra.ac.id:article/1630 2024-03-18T00:56:32Z JFM:YRS

EVALUATION OF THE USE OF THE DRUG IN PATIENTS ACUTE RESPIRATORY TRACT INFECTION (ARI) NON PNEUMONIA AT PUSKESMAS SIGUMPAR Sihombing, Yanna Rotua Romauli Anna teresia Marbun Friska Novita Pasaribu Novidawati Br Situmorang ISPA, Non Pneumonia, Community Health center Acute Respiratory Infection (ARI) is one of the main causes of patient visits to health centers (40%-60%) and hospitals (15%-30%). In Indonesia the level of use of antibiotics is still quite high. The unwise use of antibiotics and the incorrect application of standard precautions in health care facilities an lead to the occurrence of resistane. This study aims to determine the evaluation of drug use in non-pneumonia Aucute Respiratory Infection (ARI) patients at the Sigumpar Health Center. This Type of research is an observational study with a descriptive design and data taken retrospectively. The total sample of 101 medical records was taken by purposive sampling technique. The patients who often suffer from non-pneumonia acute respiratory infections at the Sigumpar Health Center occur in the age group of 6-11 years, namely children by 20,79%. Based on the results of this study, the most widely used drugs were analgesic-antipyretic (69.30%), antihistamine (65.34%), vitamins (62.37%), mucolytics (48.51%), expectorants (32.67%), antibiotics (27.72%) and corticosteroids (23.76%). The use antibiotics for non-pneumonia ARI patients at the Sigumpar Health Center was 27,72% so that it was categorized as not in accordance with the provisions of the Inonesian Ministry of Health in 2017 that the use of antibiotics in non-pneumonia ARI patients was ? 20%. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2023-10-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/1630 10.35451/jfm.v6i1.1630 JURNAL FARMASIMED (JFM); Vol. 6 No. 1 (2023): Jurnal Farmasimed (JFM); 9-16 Jurnal FARMASIMED (JFM); Vol 6 No 1 (2023): Jurnal Farmasimed (JFM); 9-16 2655-0814 10.35451/jfm.v6i1 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/1630/882 Copyright (c) 2023 Yanna Rotua Sihombing http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ejournal.medistra.ac.id:article/1636 2023-11-23T04:15:37Z JFM:YRS

EVALUATION OF DRUG INFORMATION SERVICES IN PATIENTS WITH DIABETES MELLITUS IN OUTPATIENT INSTALLATIONS GENERAL HOSPITAL PHARMACY COAL REGION S, Aminah . M. Br Turnip, Nur Ulina ., Mahliza Diabetes Mellitus, outpatient and PIO. Based on people's unhealthy lifestyle habits and from data on the five biggest diseases for the period July – September 2022 which shows that diabetes mellitus occupies the second level of the five biggest diseases in Batu Bara Hospital, and drug information services are very necessary because there are many patients who still do not understand what to do about drugs, this is done to minimize abuse and interactions between drugs that are not wanted by patients. To find out how drug information services are for DM patients at the Batu Bara Hospital pharmacy installation on an outpatient basis, and to identify the completeness of the information provided by pharmaceutical staff to patients at the Framing Installation at the Batu Bara General Hospital, and also to find out the problems found in technical drug information services provided to patients at the Batu Bara Regional Hospital Pharmacy Installation. This type of research is an observational study. The design of this study is qualitative by making direct observations or observations, interviews and documentation. Drug information services for diabetes mellitus patients in outpatient care at the Batu Bara Hospital pharmacy installation were in the very good category with a result of 96%. Drug information services performed by eight pharmacists consisting of six pharmacists and two pharmacy technicians for outpatient diabetes mellitus patients at the Batu Bara Hospital pharmaceutical installation have met the standards in the very good category with a yield of 96%. Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam 2023-04-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://ejournal.medistra.ac.id/index.php/JFM/article/view/1636 10.35451/jfm.v5i2.1636 JURNAL FARMASIMED (JFM); Vol. 5 No. 2 (2023): Jurnal Farmasimed (JFM); 213-217 Jurnal FARMASIMED (JFM); Vol 5 No 2 (2023): Jurnal Farmasimed (JFM); 213-217 2655-0814 10.35451/jfm.v5i2 eng https://ejournal.medistra.ac.id/index.php/JFM/article/view/1636/779 Copyright (c) 2023 Aminah . S, Nur Ulina M. Br Turnip, Mahliza . 932c04e981d25982c2f4acdf07af00d1