Relationship Between Bicarbonate (HCO₃) Levels and Carbon Dioxide Pressure (PCO₂) in Coronary Heart Disease Patients Based on Arterial Blood Gas Analysis (ABG) Results at Grandmed Hospital Lubuk Pakam
DOI:
https://doi.org/10.35451/6scq0s23Keywords:
coronary heart disease, HCO3, PCO2, Arterial Blood Analysis, Acid Base balanceAbstract
Background: Coronary Heart Disease (CHD) remains a primary contributor to global illness and mortality rates. Compromised tissue perfusion in individuals with CHD often disrupts systemic acid-base homeostasis, a physiological state evaluated via Arterial Blood Gas Analysis (ABG). Two key parameters—bicarbonate concentration (HCO₃) and partial pressure of carbon dioxide (PCO₂)—serve as primary indicators in assessing this balance. This investigation seeks to evaluate the correlation between HCO₃ levels and PCO₂ pressure among CHD patients based on ABG findings at Grandmed Hospital Lubuk Pakam. Methods: An analytical observational design utilizing a cross-sectional framework was implemented. Out of a population of 33 CHD patients, 30 eligible subjects were recruited via purposive sampling. Secondary clinical data extracted from patient medical records were statistically examined using the Pearson correlation test.. Results: Descriptive findings revealed a mean HCO₃ concentration of 24.42 mEq/L alongside a mean PCO₂ pressure of 32.42 mmHg. Normality testing verified a normal data distribution across variables (p > 0.05). Subsequent Pearson correlation testing demonstrated a highly robust, positive, and statistically significant association between HCO₃ concentrations and PCO₂ values, evidenced by p = 0.000 (p < 0.05) and a correlation coefficient of r = 0.945. Conclusion: A significant and strong positive correlation exists between bicarbonate (HCO₃) levels and carbon dioxide pressure (PCO₂) based on ABG evaluations among Coronary Heart
References
N. Hasanah, L. F. Putajaya, L. Kania, N. W. A. Ismaya, dan N. N. Aini, "Gambaran Penyakit Jantung Berdasarkan Demografi dan Penggunaan Obat," Jurnal Kesehatan, vol. 10, no. 1, hlm. 100–110, 2021.
L. F. Tampubolon, A. Ginting, dan F. E. S. Turnip, "Gambaran Faktor yang Mempengaruhi Kejadian Penyakit Jantung Koroner (PJK) di Pusat Jantung Terpadu (PJT)," Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal, vol. 13, no. 3, hlm. 1043–1052, 2023.
K. Hisyam, M. A. S. Putra, dan R. Yuliana, "Hubungan Status Gizi dan Kebiasaan Merokok dengan Kejadian Penyakit Jantung Koroner," Jurnal Kesehatan Tambusai, vol. 5, no. 2, hlm. 3230–3238, 2024.
D. Meidayanti, "Jurnal Penyakit Aterosklerosis," Jurnal Medika Hutama, vol. 2, no. 3, hlm. 2–6, 2021.
E. Pradian, A. P. Destiara, dan T. T. Maskoen, "Keseimbangan Asam Basa: Pendekatan Stewart," Journal Anesthesia & Critical Care, vol. 33, no. 2, hlm. 147–156, 2023.
E. Boedtkjer dan C. Aalkjaer, "The Solution to Bicarbonate," American Journal of Physiology-Heart and Circulatory Physiology, vol. 322, no. 4, hlm. H685–H686, 2022.
P. I. Rosanti dan S. Sumedi, "Metode Pembelajaran dalam Peningkatan Pengetahuan Interpretasi Hasil Analisa Gas Darah (AGD): Literature Review," Malahayati Nursing Journal, vol. 6, no. 2, hlm. 831–855, 2024.
C. R. Andhito, "Acid-base Balance and Blood Gas Interpretation in Cardiovascular Disease," Jurnal Ilmu Kedokteran dan Kesehatan, vol. 10, no. 12, hlm. 3480–3487, 2023.
S. Kathiravan, K. Prabha, dan B. Krishnaswamy, "Analysis of Arterial Blood Gas (ABG) Profile in Patients with Acute Heart Failure in Tertiary Care Centre at ACS Medical College," Journal of Evidence Based Medicine and Healthcare, vol. 10, no. 1, hlm. 1–4, 2023.
S. Haneef, R. Jaffer, A. Ijaz, dkk., "Correlation of Mean pH, 〖"HCO" 〗_3 and 〖"CO" 〗_2 Between Arterial Blood Gases and Venous Blood Gases in Critically Ill Patients," Pakistan Armed Forces Medical Journal, vol. 72, no. 5, hlm. 1526–1530, 2025.
M. F. S. Lase, P. R. Situmorang, R. A. K. Sihombing, dan D. S. Napitupulu, "Perbedaan Hasil Pemeriksaan AGD Antara Arteri dengan Vena pada Pasien Gagal Nafas di Rumah Sakit Santa Elisabeth Medan," Malahayati Nursing Journal, vol. 7, no. 11, hlm. 4672–4683, 2025.
H. J. Adrogué dan N. E. Madias, "Acute Sodium Bicarbonate Administration Improves Ventilatory Efficiency in Experimental Respiratory Acidosis: Clinical Implications," Journal of the American Society of Nephrology, vol. 35, no. 1, hlm. 90–99, 2024.
Z. H. Akbar dan R. H. Shareef, "The Use of Arterial Blood Gases Analysis to Evaluate Lung Injury in Children with Congenital Heart Disease Undergoing Surgery," Kufa Medical Journal, vol. 20, no. 2, hlm. 1–7, 2024.
H. Kataoka, Y. Aso, S. Harada, Y. Yamasaki, dan T. Sugata, "Improved Respiratory Function by SGLT2 Inhibitor Treatment in a Patient with Obstructive Pulmonary Disease Complicated by Heart Failure," EC Pulmonology and Respiratory Medicine, vol. 14, no. 8, hlm. 1–6, 2025.
S. Karahisar Şirali dan M. E. İnce, "Relationship Between Blood Gas and NT-proBNP in Patients Presenting with Dyspnea," Journal of Contemporary Medicine, vol. 15, no. 3, hlm. 126–131, 2025.
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